A Review of the Most Common Dermatologic Conditions and their Debilitating Psychosocial Impacts

Mian, Madeeha; Silfvast‐Kaiser, Annika; Paek, So Yeon; Kivelevitch, Darío; Menter, Alan

doi:10.23937/2643-4466/1710018

Cited by 15 publications

(10 citation statements)

References 128 publications

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“…Dermatological drug products are used to treat skin diseases such as psoriasis, acne, atopic dermatitis, and infections [1]. Development and assessment of local bioavailability of such products face significant challenges as the active pharmaceutical ingredients (APIs) from these drug products reach the site of action (skin layers) before they enter systemic circulation.…”

Section: Introductionmentioning

confidence: 99%

“…The aims of the work presented here were to use this dermal PBPK model to [11] predict clinically observed concentration-time profiles of clobetasol-17 propionate (CP) formulated in Dermovate TM cream, 0.05% obtained using the dOFM technique. (1); and [1] correlate local dermis exposure with Dermovate TM cream, 0.05% (GlaxoSmithKline Pharma, GmBH, Vienna, Austria) formulation properties. This product was identified as a case study based on the availability of clinical dermal CP concentration-time profiles using the dOFM technique to examine skin permeation.…”

Section: Introductionmentioning

confidence: 99%

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Predicting Human Dermal Drug Concentrations Using PBPK Modeling and Simulation: Clobetasol Propionate Case Study

van Osdol,

Novakovic,

Le Merdy

et al. 2024

AAPS PharmSciTech

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Quantitative in silico tools may be leveraged to mechanistically predict the dermato-pharmacokinetics of compounds delivered from topical and transdermal formulations by integrating systems of rate equations that describe permeation through the formulation and layers of skin and pilo-sebaceous unit, and exchange with systemic circulation via local blood flow. Delivery of clobetasol-17 propionate (CP) from DermovateTM cream was simulated using the Transdermal Compartmental Absorption & Transit (TCATTM) Model in GastroPlus®. The cream was treated as an oil-in-water emulsion, with model input parameters estimated from publicly available information and quantitative structure-permeation relationships. From the ranges of values available for model input parameters, a set of parameters was selected by comparing model outputs to CP dermis concentration-time profiles measured by dermal open-flow microperfusion (Bodenlenz et al. Pharm Res. 33(9):2229–38, 2016). Predictions of unbound dermis CP concentrations were reasonably accurate with respect to time and skin depth. Parameter sensitivity analyses revealed considerable dependence of dermis CP concentration profiles on drug solubility in the emulsion, relatively less dependence on dispersed phase volume fraction and CP effective diffusivity in the continuous phase of the emulsion, and negligible dependence on dispersed phase droplet size. Effects of evaporative water loss from the cream and corticosteroid-induced vasoconstriction were also assessed. This work illustrates the applicability of computational modeling to predict sensitivity of dermato-pharmacokinetics to changes in thermodynamic and transport properties of a compound in a topical formulation, particularly in relation to rate-limiting steps in skin permeation. Where these properties can be related to formulation composition and processing, such a computational approach may support the design of topically applied formulations.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predicting Human Dermal Drug Concentrations Using PBPK Modeling and Simulation: Clobetasol Propionate Case Study

van Osdol,

Novakovic,

Le Merdy

et al. 2024

AAPS PharmSciTech

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“…Pruritus and scratching can lead to pain, bleeding and sleep disturbance. Other studies have demonstrated that sleep disturbances resulting from atopic dermatitis also carry a psychosocial burden reflected by drowsiness, inability to focus, irritability, and growth restriction (4). Impacts on physical functioning include clothing restrictions, interference with indoor and outdoor activities such as bathing and swimming, and embarrassment (5).…”

Section: Consequences Of Ad In Childrenmentioning

confidence: 99%

Atopic Dermatitis: Preventing and Managing the Itch That Rashes, and a Case for the Multi-Theory Model (MTM) for Health Behavior Change for Educational Interventions

et al. 2021

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Atopic dermatitis (AD) is a multifactorial disease affected by a host of genetic, environmental, socioeconomic and demographic influences, that induce the atopic immune response in predisposed individuals. Despite treatment with topical corticosteroids to reduce skin inflammation, emollients to improve the skin barrier, and avoidance of inflammatory triggers, many patients report progressive symptoms. Management strategies are developed as modifiable environmental influences are identified. Managing atopic dermatitis requires adaptive changes in health behavior involving the patient and often the caregiver. Multi-theory models (MTM) have not yet been used in AD interventions but may prove beneficial as they use behavior concepts to predict both initiation and sustenance in education health interventions. A comprehensive approach fosters such changes by using psychological and educational strategies as adjuncts to conventional therapy. This article reviews the challenges in managing AD and the potential impact of behavioral theories. This is designed to strengthen the argument for using an MTM model in future studies of AD.

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“…Androgenetic alopecia (AGA) is a common disorder affecting more than half of adults worldwide with marked psychosocial impacts on affected individuals [1]. With the underlying pathophysiology still poorly understood, there have been extensive efforts to devise modern and more effective treatment modalities in recent times.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Efficacy of Platelet-Rich Plasma (PRP) With PRP Microneedling in Androgenetic Alopecia

Muhammad¹,

Iftikhar²,

Mashhood³

et al. 2022

Cureus

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BackgroundLimited data are available on the efficacy of platelet-rich plasma (PRP) and microneedling versus PRP alone. In this study, we aimed to compare the efficacy of PRP and microneedling with PRP alone in androgenetic alopecia (AGA). MethodologyThis prospective, randomized, interventional study was conducted in Pak-Emirates Military Hospital, Rawalpindi, from September 2020 to December 2020. In total, 60 individuals suffering from AGA of up to Hamilton-Norwood grade 4 were randomly assigned to two groups, namely, PRP+microneedling versus PRP alone. A total of three sessions, each one month apart, were offered. Pre and post-intervention photographs, hair count (/cm 2 ), hair-pull test, and physician's and patient's perception of hair loss were recorded. The data were statistically analyzed. ResultsA greater proportion of patients in the microneedling group achieved a negative hair-pull test and improved perception of hair loss compared to the PRP-alone group (82.1% vs. 51.9% and 88.0% vs. 73.9%, respectively). The percentage increase in mean hair count in the microneedling group (24.53 ± 9.49%) was significantly higher than the increase in the PRP-alone group (17.88 ± 10.15%) (p = 0.011). For grades 2 and 3 hair loss, microneedling+PRP caused a much greater increase in hair count than PRP alone. This difference was less pronounced for Norwood grade 4. No notable side effects were noted in any patient. ConclusionsCombined PRP and microneedling is more efficacious than PRP alone in patients with AGA up to Hamilton-Norwood grade 4.

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A Review of the Most Common Dermatologic Conditions and their Debilitating Psychosocial Impacts

Cited by 15 publications

References 128 publications

Predicting Human Dermal Drug Concentrations Using PBPK Modeling and Simulation: Clobetasol Propionate Case Study

Predicting Human Dermal Drug Concentrations Using PBPK Modeling and Simulation: Clobetasol Propionate Case Study

Atopic Dermatitis: Preventing and Managing the Itch That Rashes, and a Case for the Multi-Theory Model (MTM) for Health Behavior Change for Educational Interventions

Comparison of Efficacy of Platelet-Rich Plasma (PRP) With PRP Microneedling in Androgenetic Alopecia

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