A Review of the Pathology, Diagnosis and Management of Colloid Goitre

Hoang, Van Trung; Trinh, Cong Thao

doi:10.17925/ee.2020.16.2.131

Cited by 20 publications

(25 citation statements)

References 45 publications

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“…However, the use of NG ultrasound can be detected in approximately 70% of the general population 2 . NG is also known as endemic nodular goitre, simple goitre, nodular hyperplasia, nontoxic uninodular goitre or multinodular goiter 3 . NG are benign lesions; however, during clinical examination, they can mimic malignancies.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Levels of Twenty Chemical Elements in Normal Thyroid Tissue and Hypertrophic Thyroid Tissue

Zaichick

2021

Univ J Pharm Res

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Background: Goiter can appear as a palpable or visible enlargement of the thyroid gland at the base of the neck. If the goiter is accompanied by hypothyroidism or hyperthyroidism, it may be accompanied by symptoms of the underlying disorder, and nodular goiter (NG) is a health problem of international importance. The aim of this exploratory study was to assess whether there were significant changes in thyroid tissue levels of twenty chemical elements (ChE) Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn , Na, P, S, Si, Sr, V, and Zn are present in the goitrous transformed thyroid. Methods: Thyroid tissue level of twenty ChE was prospectively evaluated in 46 patients with NG and 105 healthy populations. The measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma atomic emission spectrometry, respectively. Tissue samples were divided into two parts. One was used for morphological study while the other was for ChE analysis. Results: It was found that contents of Al, B, Br, Cl, Cu, Fe, Li, Mg, Mn, Na, P, S, Si, V, and Zn are significantly higher while the I levels are lower in NG than in normal tissues. Conclusion: There are considerable changes in ChE contents in goitrous tissue of thyroid. Thus, it is reasonable to assume that the levels of these ChE in thyroid tissue can be used as NG markers. However, this topic needs additional studies. Peer Review History: Received: 19 July 2021; Revised: 11 August; Accepted: 4 September, Available online: 15 September 2021 Academic Editor: Ahmad Najib, Universitas Muslim Indonesia, Makassar, Indonesia, ahmad.najib@umi.ac.id UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewers: Prof. Dr. Hassan A.H. Al-Shamahy, Sana'a University, Yemen, shmahe@yemen.net.ye Prof. Cyprian Ogbonna ONYEJI, Obafemi Awolowo University, Ile-Ife, Nigeria, conyeji@oauife.edu.ng Similar Articles: VITAMIN A, RETINOIC ACID AND TAMIBAROTENE, A FRONT TOWARD ITS ADVANCES: A REVIEW

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Section: Introductionmentioning

confidence: 99%

“…NG can be hyper functioning, hypofunctioning, and functioning normally. Euthyroid NG is defined as localized enlargement of the thyroid gland without concomitant disruption of thyroid function 3 . For more than twenty centuries, there has been a prevailing view that NG is a minor consequence of iodine (I) deficiency.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Levels of Twenty Chemical Elements in Normal Thyroid Tissue and Hypertrophic Thyroid Tissue

Zaichick

2021

Univ J Pharm Res

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“…However, using ultrasonography NG can be detected in almost 70% of the general population [2]. NG is also known as endemic nodular goitre, simple goitre, nodular hyperplasia, nontoxic uninodular goitre or multinodular goiter [3]. NG is benign lesions; however, during clinical examination, they can mimic malignant tumors.…”

Section: Introductionmentioning

confidence: 99%

“…NG can be hyperfunctioning, hypofunctioning, and normal functioning. Euthyroid NG is defined as a local enlargement of thyroid without accompanying disturbance in thyroid function [3].…”

Section: Introductionmentioning

confidence: 99%

Determination of twenty chemical element contents in normal and goitrous thyroid using X-ray fluorescent and neutron activation analysis

Zaichick¹

2021

World J. Adv. Res. Rev.

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Nodular goiter (NG) is an internationally important health problem. The aim of this exploratory study was to examine the content of silver (Ag), bromine (Br), calcium (Ca), chlorine (Cl), cobalt (Co), chromium (Cr), cooper (Cu), iron (Fe), mercury (Hg), iodine (I), potassium (K), magnesium (Mg), manganese (Mn), sodium (Na), rubidium (Rb), ammonium (Sb), scandium (Sc), selenium (Se), strontium (Sr), and zinc (Zn) in the normal thyroid and in the thyroid tissues with diagnosed colloid NG.. Thyroid tissue levels of twenty chemical elements (ChE) were prospectively evaluated in 46 patients with NG and 105 healthy inhabitants. Measurements were performed using non-destructive energy-dispersive X-Ray fluorescent analysis combined with instrumental neutron activation analysis with high resolution spectrometry of short– and long-lived radionuclides. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for ChE analysis. It was found that during a goitrous transformation the levels of Ag, Br, Cl, Co, Cu, Fe, Hg, Mg, Na, and Sc in thyroid tissue significantly increased, whereas the levels of I and Sr decrease. It was supposed that the changes in levels Ag, Br, Cl, Co, Cu, Fe, Hg, I, Mg, Na, Sc, and Sr in thyroid tissue can be used as NG markers.

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“…However, because there is a 20% possibility of malignant transformation, TA should be differentiated from other thyroid nodular diseases such as nodular goiter (NG) and thyroid cancer (TC). The distinguishing between the TA and TC is tricky, therefore new differential diagnostics and TA biomarkers are needed [2,3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of twenty chemical element contents in thyroid adenomas using neutron activation analysis and inductively coupled plasma atomic emission spectrometry

Zaichick¹

2021

World J. Adv. Res. Rev.

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Thyroid adenomas (TA) are benign tumors, but there is a 20% possibility of malignant transformation. The distinguishing between the TA and thyroid cancer (TC) is tricky, therefore new TA biomarkers are needed. Furthermore, the role of chemical elements (ChE) in etiology and pathogenesis of TA is unclear. The aim of this exploratory study was to evaluate whether significant changes in the thyroid tissue levels of twenty chemical elements (ChE) Al, B, Ba, Br, Ca, Cl, Cu, Fe, I, K, Li, Mg, Mn, Na, P, S, Si, Sr, V, and Zn exist in the adenomatous transformed thyroid. Thyroid tissue levels of twenty ChE were prospectively evaluated in 19 patients with TA and 105 healthy inhabitants. Measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis and inductively coupled plasma atomic emission spectrometry, respectively. Tissue samples were divided into two portions. One was used for morphological study while the other was intended for ChE analysis. It was found that contents of of Al, B, Br, Cl, Cu, Na, and Zn are significantly higher whereas the levels of I some lower. in TA than in normal tissues. It was supposed that the changes in levels Al, B, Br, Cl, Cu, I, Na, and Zn in thyroid tissue can be used as TA markers.

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A Review of the Pathology, Diagnosis and Management of Colloid Goitre

Cited by 20 publications

References 45 publications

Comparison of Levels of Twenty Chemical Elements in Normal Thyroid Tissue and Hypertrophic Thyroid Tissue

Comparison of Levels of Twenty Chemical Elements in Normal Thyroid Tissue and Hypertrophic Thyroid Tissue

Determination of twenty chemical element contents in normal and goitrous thyroid using X-ray fluorescent and neutron activation analysis

Evaluation of twenty chemical element contents in thyroid adenomas using neutron activation analysis and inductively coupled plasma atomic emission spectrometry

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