A Review of the Prophylaxis and Treatment of Postoperative Nausea and Vomiting

Scott-Walker, Trudie M; Ball, Patrick; Berry, Paul R.

doi:10.1002/jppr2000304157

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2003

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“…4 Advances in anaesthesia and the use of antiemetics have reduced PONV. 5 Antiemetics may be administered pre-operatively or intra-operatively for prophylaxis, or postoperatively as acute treatment of established PONV. While the use of antiemetics for prophylaxis has been extensively reported, there is less evidence of efficacy for treatment.…”

Section: Introductionmentioning

confidence: 99%

5‐HT₃ Antagonists in the Treatment of Postoperative Nausea and Vomiting

Pham

Langford²,

Williams

2003

Pharmacy Practice and Res

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Background: Postoperative nausea and vomiting (PONV) can affect up to 30% of patients. While the use of antiemetics for prophylaxis has been extensively reported there is less evidence of their efficacy for the treatment of PONV. Aim: To review the evidence and discuss the use of 5-hydroxytryptamine type 3 (5-HT 3 ) antagonists for the treatment of PONV in Australia. Method: A literature search was conducted to identify clinical studies evaluating the effects of 5-HT 3 antagonists in the treatment of PONV. Results: In four studies various doses of 5-HT 3 antagonists were compared and in five studies a single dose of 5-HT 3 antagonist was assessed against another antiemetic or placebo, or both. Conclusion: These studies indicate that 5-HT 3 antagonists are effective and safe in the treatment of PONV.

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Section: Introductionmentioning

confidence: 99%