A Review of the Relationship Between the Appetite-Regulating Hormone Leptin Present in Human Milk and Infant Growth

Alimentação de recém-nascidos através da utilização do copo: revisão integrativa de literatura

“…6 Ainda, a oferta da dieta em ritmo acelerado, controlada pelo adulto, como é o caso da mamadeira, poderia interferir, junto com o tipo de alimentação, na regulação dos hormônios de apetite e saciedade, 25 predispondo a sobrepeso e obesidade, bem como os riscos cardiometabólicos correlacionados. Castell e colaboradores, 26 demonstraram haver relação inversa entre leptina (hormônio da saciedade) e ganho de peso em lactentes, corroborando a relevância do método alimentar estar em domínio do recém-nascido para adequada autorregulação de ingestão, e, possivelmente, melhor relação futura com os alimentos, ratificando os apontamentos de Malhotra e colaboradores 14 que apresentou menos de 10% de desperdício de leite. 13,14,15 Por ceder facilmente à compressão, o copo plástico descartável 24 mostrou-se inadequado, apresentando alta porcentagem de derramamento (42% em mais de 60% da amostra), especialmente quanto menor for a idade gestacional do lactente.…”

Breast milk leptin concentrations and infant anthropometric indicators in SGA versus non-SGA breastfed infants born at term

“…An epidemiological literature review about the relationship between the appetite-regulating hormone leptin in human milk with growth and infant weight gain found that there was evidence to establish their direct effect association on the growth and development of infant weight [ 5 ]. However, the mechanism by which leptin is related to infant weight gain is still unclear, as the results are conflicting, because a variety of maternal confounding factors, such as BMI, diet, and lifestyle, among other variables, are often neglected [ 5 ].…”

“…Also leptin was identified as playing a crucial role in the postnatal programming of a healthy phenotype, establishing the concept of long-term regulation of body fat stores [ 4 ]. A recent systematic review showed an inverse relationship between leptin in human milk and infant weight and five researchers reported the effect on satiety and self-regulation of infant intake [ 5 ]. Even though numerous factors are involved in the development of obesity in adulthood, there is evidence that leptin resistance promotes reduced satiety over-consumption of nutrients, and increased body mass index (BMI) [ 3 ].…”

Breast Milk Leptin Concentrations and Infant Anthropometric Indicators in SGA Versus Non-SGA Breastfed Infants Born at Term

“…However, the rigorous methodology for inclusion in the sample groups restricted the sample size [9]. An epidemiological literature review about the relationship between the appetite-regulating hormone leptin in human milk with growth and infant weight gain found that there was evidence to establish their direct effect association on the growth and development of infant weight [5]. However, the mechanism by which leptin is related to infant weight gain is still unclear, as the results are conflicting, because a variety of maternal confounding factors, such as BMI, diet, and lifestyle, among other variables, are often neglected [5].…”