“…They reviewed the evidence for relationships between metabolic activity of cortical, subcortical and limbic brain regions in depression and the efficacy of antidepressant agents". "These influences of regions can be described by an algebraic equation, N = H/(M+R), where N represents a homeostatic level of executive function, H represents prefrontal (Brodmann areas, 9,10,11,12,46) and M represents cingulate activity and R represents limbic (amygdala) influences". They proposed a hypothesis on the basis of their findings indicated by fMRI and /or PET in the review of literature search that depressed prefrontal cortex and enhanced amygdala and hippocampus metabolism are cause of MDD, and that the remission from antidepressant treatments is the results of normalization of the above changes to restore the metabolism indicated by neuronal imaging in depression.In normal subjects, N = H/(M+R), in depression, Nd <N, and in remission, Nr = N, respectively are found in the results of their review of treatment results.…”