A Review of the Role of Mechanical Forces in Cutaneous Wound Healing

Agha, Riaz; Ogawa, Rei; Pietramaggiori, Giorgio; Orgill, Dennis P.

doi:10.1016/j.jss.2011.07.007

Cited by 147 publications

(146 citation statements)

References 121 publications

(119 reference statements)

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“…Migrating cells exert mechanical forces, including a protrusive force at the front edge of the leading cells, an intercellular contractile force and a traction force between the migrating and immediately adjacent cells (du Roure et al, 2005). Recent studies have demonstrated that appropriate exogenous mechanical forces accelerate cutaneous wound healing (Ogawa, 2011;Agha et al, 2011). Keratinocytes are believed to sense these endogenous and exogenous forces through mechanoreceptors that induce a transient influx of extracellular Ca 2+ to regulate cell migration (Lee et al, 1999) and proliferation (Yano et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes

Takada

Furuya

Sokabe

2014

Journal of Cell Science

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Cutaneous wound healing is accelerated by exogenous mechanical forces and is impaired in TRPC6-knockout mice. Therefore, we designed experiments to determine how mechanical force and TRPC6 channels contribute to wound healing using HaCaT keratinocytes. HaCaT cells were pretreated with hyperforin, a major component of a traditional herbal medicine for wound healing and also a TRPC6 activator, and cultured in an elastic chamber. At 3 h after scratching the confluent cell layer, the ATP release and intracellular Ca 2+ increases in response to stretching (20%) were live-imaged. ATP release was observed only in cells at the frontier facing the scar. The diffusion of released ATP caused intercellular Ca 2+ waves that propagated towards the rear cells in a P2Y-receptor-dependent manner. The Ca 2+ response and wound healing were inhibited by ATP diphosphohydrolase apyrase, the P2Y antagonist suramin, the hemichannel blocker CBX and the TRPC6 inhibitor diC8-PIP 2 . Finally, the hemichannel-permeable dye calcein was taken up only by ATP-releasing cells. These results suggest that stretch-accelerated wound closure is due to the ATP release through mechanosensitive hemichannels from the foremost cells and the subsequent Ca 2+ waves mediated by P2Y and TRPC6activation.

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Section: Introductionmentioning

confidence: 99%

Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes

Takada

Furuya

Sokabe

2014

Journal of Cell Science

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“…Acute wounds are considered to progress naturally through the cellular events that occur in the cicatrization stages (37). However, it is considered important to carry out studies with a similar design, including detailed information on the parameters used, to prove the effects of the different frequencies of TENS on wound cicatrization.…”

Section: Discussionmentioning

confidence: 99%

Effect of high- and low- frequency transcutaneous electrical nerve stimulation (TENS) on angiogenesis and wound contraction in acute excisional wounds in rat skin

et al. 2017

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Introduction: Transcutaneous electrical nerve stimulation (TENS) can alter the local temperature, increase skin blood flow and induce the release of vasodilator neuropeptides and growth factors. These changes may be related to the effects of TENS on the tissue repair process. Objective: To assess the effect of high-and low-frequency TENS on angiogenesis and the contraction of acute excisional wounds in rat skin. Methods: Fifty-four young adult male EPM1-Wistar rats were used in the study. An excisional wound was performed on the back of each animal using an 8mm punch. The animals were randomly assigned to three groups: the

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“…Increased skin tension can stimulate fibroblasts to produce collagen through the use of growth factors and other cytokines. 15 Repeated motions in high skin tension areas can cause continuous stimulation of collagen production by fibroblast, which then leads to compression on the dermis area. This leads to disruption of the blood vessel and decreased oxygen tension that will cause higher TGF-β1 activities.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effectiveness of Phosphorus 32 Application and 10 Mg/Cc Triamcinolone Acetonide Intralesional Injection on Keloid

Indrayati

Agusni

Soedarwoto

et al. 2016

IJIHS

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Objective: To analyze the effectiveness of phosphorus 32 ( Results: Lesions were divided into two groups with each group consisted of 26 lesions. Group A was treated with 32 P application whereas group B was treated with 10 mg/cc TA intralesional injection. Flattening of the lesion of more than 50% was higher in the group treated with 32 P application (76.9%) compared to the group that was treated with 10 mg/cc TA intralesional injection (57.7%) on the 8 th week, but the difference was not statistically significant (p>0.05). Conclusions:Based on the statistical analysis, the application of 32 P was as effective as the intralesional injection of 10 mg/cc TA for keloid lesions.

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A Review of the Role of Mechanical Forces in Cutaneous Wound Healing

Cited by 147 publications

References 121 publications

Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes

Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes

Effect of high- and low- frequency transcutaneous electrical nerve stimulation (TENS) on angiogenesis and wound contraction in acute excisional wounds in rat skin

Comparison of the Effectiveness of Phosphorus 32 Application and 10 Mg/Cc Triamcinolone Acetonide Intralesional Injection on Keloid

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