A review of the role of liposome-encapsulated phytochemicals targeting PPAR Ɣ and associated pathways to combat obesity

Shaji, Athira; Jayasri, M. A.

doi:10.1007/s13205-023-03740-7

Cited by 2 publications

(2 citation statements)

References 96 publications

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“…Other widely studied alterations include loss-of-function variants of the gene that encodes adenylate cyclase 3, which is widely distributed, predominantly in adipose and subcutaneous tissue, but also participates in the correct functioning of the MC4R gene [ 10 ] and in the synthesis of cyclic adenosine monophosphate (cAMP), which functions as a second messenger in the glucagon-like peptide-1 (GLP-1) signaling pathway, the hormone ghrelin and the melanocortin-stimulating hormone [ 10 ], POMC , Fat Mass and Obesity ( FTO ) [ 11 ], interleukin 6 ( IL-6 ) [ 12 ], perilipin ( PLIN ) [ 13 ], adiponectin ( ADIPOQ ) [ 14 ], LEP [ 15 ], LEPR [ 16 ], POMC [ 17 ] genes, the family of peroxisome proliferator-activated receptors (PPAR) [ 18 ] and the uncoupling proteins (UCPs) [ 19 ], which are related to the activation of thermogenesis. These genes and their metabolic and signaling pathways have a close relationship with systemic oxidative stress and inflammation, both critically related to the development of obesity and the appearance of many linked comorbidities [ 6 , 20 ].…”

Section: Etiopathogenic Mechanisms Of Obesitymentioning

confidence: 99%

Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

Hidalgo-Lozada,

Villarruel-López,

Nuño

et al. 2024

IJMS

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The prevalence and incidence of obesity and the comorbidities linked to it are increasing worldwide. Current therapies for obesity and associated pathologies have proven to cause a broad number of adverse effects, and often, they are overpriced or not affordable for all patients. Among the alternatives currently available, natural bioactive compounds stand out. These are frequently contained in pharmaceutical presentations, nutraceutical products, supplements, or functional foods. The clinical evidence for these molecules is increasingly solid, among which epigallocatechin-3-gallate, ellagic acid, resveratrol, berberine, anthocyanins, probiotics, carotenoids, curcumin, silymarin, hydroxy citric acid, and α-lipoic acid stand out. The molecular mechanisms and signaling pathways of these molecules have been shown to interact with the endocrine, nervous, and gastroenteric systems. They can regulate the expression of multiple genes and proteins involved in starvation–satiety processes, activate the brown adipose tissue, decrease lipogenesis and inflammation, increase lipolysis, and improve insulin sensitivity. This review provides a comprehensive view of nature-based therapeutic options to address the increasing prevalence of obesity. It offers a valuable perspective for future research and subsequent clinical practice, addressing everything from the molecular, genetic, and physiological bases to the clinical study of bioactive compounds.

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Section: Etiopathogenic Mechanisms Of Obesitymentioning

confidence: 99%

Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

Hidalgo-Lozada,

Villarruel-López,

Nuño

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Other widely studied alterations include loss-of-function variants of the gene that encodes adenylate cyclase 3, which is widely distributed, predominantly in adipose and subcutaneous tissue, but also participates in the correct functioning of the MC4R gene [10] and in the synthesis of cyclic adenosine monophosphate (cAMP), which functions as a second messenger in the glucagon-like peptide-1 (GLP-1) signaling pathway, the hormone ghrelin and the melanocortin-stimulating hormone [10], POMC, Fat Mass and Obesity (FTO) [11], interleukin 6 (IL-6) [12], perilipin (PLIN) [13], adiponectin (ADIPOQ) [14], LEP [15], LEPR [16], POMC [17] genes, the family of peroxisome proliferator-activated receptors (PPAR) [18] and the uncoupling proteins (UCPs) [19], which are related to the activation of thermogenesis. These genes and their metabolic and signaling pathways have a close relationship with systemic oxidative stress and inflammation, both critically related to the development of obesity and the appearance of many linked comorbidities [6,20].…”

Section: Genetic Factorsmentioning

confidence: 99%

Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

Hidalgo-Lozada,

Villarruel-López,

Nuño

et al. 2024

Preprint

View full text Add to dashboard Cite

The prevalence and incidence of obesity and the comorbidities linked to it are increasing in the world population. Current therapies for obesity and associated pathologies have proven to cause a broad number of adverse effects and often, they are overpriced or not affordable for all patients. Among the alternatives currently available, natural bioactive compounds stand out. These are frequently contained in pharmaceutical presentations, nutraceutical products, supplements, or functional foods. The clinical evidence for these molecules is increasingly solid, among which epigallocatechin-3-gallate, ellagic acid, resveratrol, berberine, anthocyanins, probiotics, carotenoids, curcumin, silymarin, hydroxy citric acid, and α-lipoic acid stand out. The molecular mechanisms and signaling pathways of these molecules have been shown to interact with the endocrine, nervous, and gastroenteric systems, as well as regulate the expression of multiple genes and, therefore, proteins involved in starvation-satiety processes, activation of brown adipose tissue, increased lipolysis, decreased lipogenesis, and inflammation, beneficial changes in metabolism and improved insulin sensitivity. This review provides a comprehensive view of nature-based therapeutic options to address the increasing prevalence of obesity. It offers a valuable perspective for future research and subsequent clinical practice, addressing everything from the molecular, genetic, and physiological bases to the clinical study of the bioactive compound.

show abstract

A review of the role of liposome-encapsulated phytochemicals targeting PPAR Ɣ and associated pathways to combat obesity

Cited by 2 publications

References 96 publications

Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

Clinically Effective Molecules of Natural Origin for Obesity Prevention or Treatment

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