A Review of the Therapeutic Antitumor Potential of Cannabinoids

Bogdanović, Višnja; Mrdjanović, Jasminka; Borišev, Ivana

doi:10.1089/acm.2017.0016

Cited by 40 publications

(30 citation statements)

References 62 publications

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“…This is based on an increasing body of preclinical evidence showing cannabinoids to be capable, under some conditions, of inhibiting the development of cancer cells in vitro or in vivo by various mechanisms of action, including induction of apoptosis, inhibition of angiogenesis, and arresting the cell cycle [16]. This is certainly exciting news, and research is ongoing around the world, but there is no solid clinical evidence yet to support that cannabinoids -whether natural or synthetic -can effectively and safely treat cancer in actual humans [17].…”

Section: Therapeutic Effects Of Cbdmentioning

confidence: 99%

The Trouble with CBD Oil

Hazekamp¹

2018

Med Cannabis Cannabinoids

157

129

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In just a few years, cannabidiol (CBD) has become immensely popular around the world. After initially being discovered as an effective self-medication for Dravet syndrome in children, CBD is now sold and used to treat a wide range of medical conditions and lifestyle diseases. The cannabinoid CBD, a non-psychoactive isomer of the more infamous tetrahydrocannabinol (THC), is available in a growing number of administration modes, but the most commonly known is CBD oil. There are currently dozens, if not hundreds, of producers and sellers of CBD oils active in the market, and their number is increasing rapidly. Those involved vary from individuals who prepare oils on a small scale for family and (Facebook) friends to compounding pharmacies, pharmaceutical companies, and licensed cannabis producers. Despite the growing availability of CBD, many uncertainties remain about the legality, quality, and safety of this new “miracle cure.” As a result, CBD is under scrutiny on many levels, ranging from national health organizations and agricultural lobbyists to the WHO and FDA. The central question is whether CBD is simply a food supplement, an investigational new medicine, or even a narcotic. This overview paper looks into the known risks and issues related to the composition of CBD products, and makes recommendations for better regulatory control based on accurate labeling and more scientifically supported health claims. The intention of this paper is to create a better understanding of the benefits versus the risks of the current way CBD products are produced, used, and advertised.

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Section: Therapeutic Effects Of Cbdmentioning

confidence: 99%

The Trouble with CBD Oil

Hazekamp¹

2018

Med Cannabis Cannabinoids

157

129

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“…A large number of studies have been undertaken to evaluate the anticancer activity of plant and synthetic cannabinoids (Guzman, ; Fraguas‐Sanchez et al, ; Velasco et al, ; Bogdanovic et al, ). Regarding endocannabinoids, their exogenous administration has also been reported to reduce the proliferation, migration and invasion of tumours.…”

Section: Endocannabinoid Antitumour Activitymentioning

confidence: 99%

Insights into the effects of the endocannabinoid system in cancer: a review

Fraguas-Sánchez

Martín-Sabroso

Torres-Suárez

2018

British J Pharmacology

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In the last few decades, the endocannabinoid system has attracted a great deal of interest in terms of its applications to clinical medicine. In particular, its applications in cancer probably represent one of the therapeutic areas with most promise. On the one hand, expression of the endocannabinoid system is altered in numerous types of tumours, compared to healthy tissue, and this aberrant expression has been related to cancer prognosis and disease outcome, suggesting a role of this system in tumour growth and progression that depends on cancer type. On the other hand, cannabinoids exert an anticancer activity by inhibiting the proliferation, migration and/or invasion of cancer cells and also tumour angiogenesis. However, some cannabinoids, at lower concentrations, may increase tumour proliferation, inducing cancer growth. Enough data has been provided to consider the endocannabinoid system as a new therapeutic target in cancer, although further studies to fully establish the effect of cannabinoids on tumour progression are still needed.

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“…The second group is the inhibition of tumor angiogenesis, invasiveness, and metastasis. The third mechanism is the modulation of the antitumor immune response (45,46,47,48,49,50,51,52).…”

Section: Cannabinoids As Antitumor Therapiesmentioning

confidence: 99%

“…Cannabinoids have a certain effect on tumor cells that are highly resistant to routine chemotherapy. This mechanism may be due to the fact that the administration of cannabinoids with other chemotherapy or radiotherapy increases the sensitivity of tumor cells to antitumor therapy (45,46,47,48,49,50,51,52). Cannabinoids are believed to have a synergistic effect with antitumoral chemotherapy and radiotherapy (45).…”

Section: Combination Of Cannabinoids With Other Anticancer Treatmentsmentioning

confidence: 99%

The role of cannabinoids in the treatment of cancer

Večeřa¹,

Gabrhelik²,

Prášil³

et al. 2020

BLL

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The aim of this review article is to summarize current knowledge about the role of cannabinoids and cannabinoid receptors in tumor disease modulation and to evaluate comprehensively the use of cannabinoids in cancer patients. METHOD: According to the PRISMA protocol, we have included data from a total of 105 articles. RESULTS: Cannabinoids affect cancer progression by three mechanisms. The most important mechanism is the stimulation of autophagy and affecting the signaling pathways leading to apoptosis. The most important mechanism of this process is the accumulation of ceramide. Cannabinoids also stimulate apoptosis by mechanisms independent of autophagy. Other mechanisms by which cannabinoids affect tumor growth are inhibition of tumor angiogenesis, invasiveness, metastasis, and the modulation of the anti-tumor immune response. CONCLUSION: In addition to the symptomatic therapy of cancer patients, the antitumor effects of cannabinoids (whether in monotherapy or in combination with other cancer therapies) have promising potential in the treatment of cancer patients. More clinical trials are needed to demonstrate the antitumor effect of cannabinoids (Tab. 1, Fig. 1, Ref. 167).

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A Review of the Therapeutic Antitumor Potential of Cannabinoids

Cited by 40 publications

References 62 publications

The Trouble with CBD Oil

The Trouble with CBD Oil

Insights into the effects of the endocannabinoid system in cancer: a review

The role of cannabinoids in the treatment of cancer

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