A review of the topical management of acne and its associated sequelae in the Asia‐Pacific region with a spotlight on trifarotene

Abstract

Acne, a highly prevalent skin disease, can be particularly bothersome for patients of Asian background because of its impact on self‐confidence and social interactions. In addition to active acne lesions, some patients may develop sequelae such as scarring, macular/postinflammatory hyperpigmentation, or erythema. The tendency of Asian skin to develop sequelae because of its increased susceptibility to irritation, cultural preferences for lighter skin phototypes, and differences in skincare regimens may all contribute to the increased burden of acne. Moreover, many Asia‐Pacific countries do not have their own guidelines for acne management, and those that do often have no schedule in place for regular updates. In this article, we provide a critical review of the published guidance for the management of acne and its sequelae in the Asia‐Pacific region, identifying gaps in current recommendations that could be addressed to enhance standards of acne care in Asia‐Pacific countries. Along with highlighting the importance of a comprehensive skincare regimen to increase treatment efficacy and adherence, we discuss topical retinoids and retinoid combination options in the acne armamentarium that may be beneficial for sequelae prevention and management, such as adapalene 0.3% ± benzoyl peroxide 2.5%, tretinoin 0.05%, tazarotene 0.1%, and trifarotene 0.005%. In particular, trifarotene 0.005% has been observed to significantly reduce acne scar counts in a Phase 4 study. The recent data highlight the need to establish up‐to‐date guidance for acne and acne sequelae management in Asia‐Pacific countries to provide optimal care to Asian patients.

Editor's Highlights – June 2024

“…In the second paper, See et al 2 take a broader approach while also focusing on trifarotene, reviewing its utility across different populations and skin types, with particular attention to Asian skin, which is prone to irritation and pigmentation issues. This review discusses the pathogenesis of acne-induced sequelae, focusing on the specifics of acne in SOC patients.…”

Trifarotene‐based holistic management of acne

“…Besides UV protection, an optimized skin care regimen in combination with trifarotene is critical to support the skin barrier, which is often impaired in both treated dry and untreated lipid-rich acne skin (Figure 1). Also, in this issue, See et al 5 bring a new perspective to acne management, focusing on topical retinoid-based treatments by highlighting factors specific to different regions of the world. Using the example of acne patients from the Asia-Pacific region, whose skin has a thinner stratum corneum, higher eccrine gland activity, and a less effective barrier to sensitizing or irritating substances, coupled with the use of region-specific skin care products and cultural preferences for a lighter skin phenotype, they suggest improving and harmonizing regional acne guidelines.…”