A review of therapeutic potential of Saussurea lappa-An endangered plant from Himalaya

Abstract

There are 300 known Saussurea species. Among them, Saussurea lappa (S. lappa) is a representative perennial herb, globally distributed across Himalaya region. S. lappa has been traditionally used in medicines without obvious adverse effects. Despite significant progress in phytochemical and biological analyses of S. lappa over the past few years, inclusive and critical reviews of this plant are anachronistic or quite limited in scope. The present review aims to summarize up-to-date information on the active constituents, pharmacology, traditional uses, trade and challenges in conservation and sustainable use of S. lappa from the literature. In addition to botanical studies and records of the traditional use of S. lappa in over 43 diseases, scientific studies investigating the latent medicinal uses of this species and its constituent phytochemicals for a range of disorders are presented and discussed. The structure, bioactivity, and likely mechanisms of action of S. lappa and its phytochemicals are highlighted. Although some progress has been made, further scrupulous efforts are required to investigate the individual compounds isolated from S. lappa to validate and understand its traditional uses and develop clinical applications. The present review offers preliminary information and gives direction for further basic and clinical research into this plant.

Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones

“…Clark or Saussurea costus (Falc.) Lipsch (Asteraceae) (Scheme 12 ) [130] and has been found to show cytotoxicity against the HepG2 and PLC/PRF/5 human liver cancer cell lines [131] and to inhibit the growth of the DU145 human prostate cancer cell line [132]. The molecular structure of this agent was determined by analysis of its single-crystal X-ray diffraction parameters (Scheme 12 ) [133], and (±)-DHL was synthesized by formation of a five-membered ring through a 1,8-addition with a Grignard reagent, completion of a regio- and stereoselectively-butyrolactone via epoxide opening with dilithioacetate, and introduction of three exocyclic methylene groups [134].…”

Conservation Status and Therapeutic Potential of <i>Saussurea lappa</i>: An Overview

“…lappa status is critically endangered according to [43]. Due to of limited geographical ranges and precise territories endemic and erratic taxa of an area are at risk [44].…”

Ájurvéda az elhízás kezelésében

“…Kosztunolid-(germakránvázas, 10 tagú monociklikus szeszkviterpén lakton) tartalma gátolja az IL-1β-mRNS expresszióját, hozzájárulva az antiinflammatorikus hatás-hoz. Túlsúlyos nyulakon végzett kísérletekben bebizonyosodott, hogy az indiai törpebogáncs gyökerének vizes kivonata per os adagolva hypolipidaemiás hatású, szignifikánsan csökkent a szérum triglicerid-és koleszterinszintje [16].…”