A Review of Thin Films Used in Smart Contact Lenses

Kareem, Mujeeb O.; Agbaje, Taofeeqah A.; Alam, Fahad; Butt, Haider

doi:10.1002/adem.202300363

Cited by 7 publications

(2 citation statements)

References 85 publications

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“…Although constant progress has been made on developing contact lens sensors for 24h IOP monitoring, current models often encounter challenges such as the need for a power supply or bulky electronic components causing vision interference or corneal damage. [67] Most traditional noise-reduction methods involve bulky external circuits, which induce additional noise interference and prevent the sensor from accurately detecting IOP signals. [68] To effectively reduce blinking-induced noise interference, many previous studies have attempted to reduce the surface coefficient of friction by attaching a lubricant to the contact lens surface.…”

Section: Iop Monitoringmentioning

confidence: 99%

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell‐based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.

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Section: Iop Monitoringmentioning

confidence: 99%

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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“…By enabling real-time monitoring of personal health data, SCLs eliminate the need for frequent hospital visits or reliance on bulky medical equipment [39][40][41]. Consequently, the development of SCL devices, particularly considering the rapid advancements in Internet of Things (IoT) technology, emerges as a pivotal research area [42,43]. In this section, the materials suitable for SCLs, electrical components used to activate the lenses, fabrication methods, and applications are briefly explained and shown in Figure 2.…”

Section: Materials and Applications Of Sclsmentioning

confidence: 99%

Smart Contact Lenses—A Step towards Non-Invasive Continuous Eye Health Monitoring

Kazanskiy,

Khonina,

Butt

2023

Biosensors

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According to the age-old adage, while eyes are often considered the gateway to the soul, they might also provide insights into a more pragmatic aspect of our health: blood sugar levels. This potential breakthrough could be realized through the development of smart contact lenses (SCLs). Although contact lenses were first developed for eyesight correction, new uses have recently become available. In the near future, it might be possible to monitor a variety of ocular and systemic disorders using contact lens sensors. Within the realm of glaucoma, SCLs present a novel prospect, offering a potentially superior avenue compared to traditional management techniques. These lenses introduce the possibility of non-invasive and continuous monitoring of intraocular pressure (IOP) while also enabling the personalized administration of medication as and when needed. This convergence holds great promise for advancing glaucoma care. In this review, recent developments in SCLs, including their potential applications, such as IOP and glucose monitoring, are briefly discussed.

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Innovations in Silicone Hydrogels: Achieving High Oxygen Permeability with Maintained Equilibrium Water Content

Liu,

Chang,

Lee

et al. 2024

Adv Eng Mater

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Silicone hydrogels are pivotal materials used in contact lenses, biomedicine, and electronic devices, where oxygen permeability and equilibrium water content (EWC) are essential attributes. Generally, an increase in silicone content boosts oxygen permeability but diminishes EWC, presenting a notable trade‐off challenge. In this study, a solvent incorporation method that significantly elevates oxygen permeability without markedly affecting EWC is introduced. Among various solvents, isopropanol incorporation notably enhances oxygen permeability (101 barrer) while maintaining an EWC of 56.0%. This improvement is attributed to enhanced connectivity within the silicone network. Additionally, it is discovered that incorporating siloxane nanoparticles (SNPs) further increases the connectivity of the silicone network, offering a more pronounced improvement in oxygen permeability than solvent alone. However, excessive SNP addition can lead to large phase separation, resulting in decreased transmittance, lower EWC, and increased mechanical strength. Optimizing a transmittance of over 99%, SNP addition achieves a silicone hydrogel with an oxygen permeability of 125 barrer and an EWC of 49.5%, surpassing many advancements reported in the literature.

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A Review of Thin Films Used in Smart Contact Lenses

Cited by 7 publications

References 85 publications

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Smart Contact Lenses—A Step towards Non-Invasive Continuous Eye Health Monitoring

Innovations in Silicone Hydrogels: Achieving High Oxygen Permeability with Maintained Equilibrium Water Content

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