A review of toxicity induced by persistent organic pollutants (POPs) and endocrine-disrupting chemicals (EDCs) in the nematode Caenorhabditis elegans

Chen, Haibo; Wang, Chen; Li, Hui; Ma, Ruixue; Yu, Zhiming; Li, Liangzhong; Xiang, Ming; Chen, Xichao; Hua, Xin; Yu, Yunjiang

doi:10.1016/j.jenvman.2019.02.102

Cited by 97 publications

(27 citation statements)

References 46 publications

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“…For instance, of the various Ecdysozoa groups, only three (Insecta, Crustacea and Nematoda) have been thoroughly examined from an endocrinology standpoint [32]. Moreover, several aquatic pollutants have been reported to retard growth and moulting and influence mortality in crustaceans [61][62][63] and to affect growth, reproduction, life span and gene expression in nematodes [64,65]. Importantly, one of the clearest examples of endocrine disruption -imposex development in gastropods upon exposure to organotins, was shown to result from a specific interaction with the highly conserved NR RXR [66][67][68].…”

Section: Discussionmentioning

confidence: 99%

An Orthologue of the Retinoic Acid Receptor (RAR) Is Present in the Ecdysozoa Phylum Priapulida

Fonseca

Hiromori

Kaite

et al. 2019

Genes

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Signalling molecules and their cognate receptors are central components of the Metazoa endocrine system. Defining their presence or absence in extant animal lineages is critical to accurately devise evolutionary patterns, physiological shifts and the impact of endocrine disrupting chemicals. Here, we address the evolution of retinoic acid (RA) signalling in the Priapulida worm, Priapulus caudatus Lamarck, 1816, an Ecdysozoa. RA signalling has been shown to be central to chordate endocrine homeostasis, participating in multiple developmental and physiological processes. Priapulids, with their slow rate of molecular evolution and phylogenetic position, represent a key taxon to investigate the early phases of Ecdysozoa evolution. By exploring a draft genome assembly, we show, by means of phylogenetics and functional assays, that an orthologue of the nuclear receptor retinoic acid receptor (RAR) subfamily, a central mediator of RA signalling, is present in Ecdysozoa, contrary to previous perception. We further demonstrate that the Priapulida RAR displays low-affinity for retinoids (similar to annelids), and is not responsive to common endocrine disruptors acting via RAR. Our findings provide a timeline for RA signalling evolution in the Bilateria and give support to the hypothesis that the increase in RA affinity towards RAR is a late acquisition in the evolution of the Metazoa.

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Section: Discussionmentioning

confidence: 99%

An Orthologue of the Retinoic Acid Receptor (RAR) Is Present in the Ecdysozoa Phylum Priapulida

Fonseca

Hiromori

Kaite

et al. 2019

Genes

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“…Oxidative stress is frequently induced by toxicants and is thought to be a common toxic mechanism in C. elegans (Chen et al, 2019). Thus, we investigated whether oxidative stress is involved in DA-induce toxicity in nematodes.…”

Section: Oxidative Stress Is a Potential Mechanism Of Da-induced Toximentioning

confidence: 99%

Toxic Effects of Domoic Acid on Caenorhabditis elegans and the Underlying Mechanism

Tian¹,

Zhang²

2019

IJB

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Domoic acid (DA) is a well-known marine bio-toxin and has been investigated extensively through many in vitro and in vivo studies. However, the mechanism for DA-induced toxicity is still not fully understood. In the present study, we performed toxicity assessment of DA in Caenorhabditis elegans system and investigated the underlying mechanism for DA-induced toxicity. Our data show that DA exposure has toxic effects on locomotion behavior, lifespan and intestine of nematodes. Moreover, we observed the increased reactive oxygen species (ROS) formation in DA exposed nematodes, implying the involvement of oxidative stress in DA-induced toxicity. In addition, our data demonstrates that p38 signaling pathway is required for the DA-induced ROS formation and toxicity. Therefore, our study proves the effectiveness of C. elegans system in toxicity assessment of DA, and DA may induce toxicity through p38 pathway dependent oxidative stress.

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“…By regulating biogeochemical cycles and ecosystem processes, including mineralization and decomposition of organic matter (Griffiths et al, 1998;Bardgett et al, 1999;Ferris, 2010), they are key organisms in the soil food web. The soil-dwelling bacterivorous nematode Caenorhabditis elegans, distributed world-wide, is a well-established model organism for ecotoxicological tests of different kinds of pollutants such as mycotoxins, persistent organic pollutants and endocrinedisrupting compounds (Leung et al, 2008;Keller et al, 2018;Chen et al, 2019) and has been used for biosafety assessments of nanoparticles (Wu et al, 2019). Fang-Yen et al (2009) observed that C. elegans can ingest polystyrene beads that can further be transported into the intestine, a possible entry route of MP into the soil food web (Rillig et al, 2017a).…”

Section: Introductionmentioning

confidence: 99%

Microplastics Effects on Reproduction and Body Length of the Soil-Dwelling Nematode Caenorhabditis elegans

Schöpfer

Menzel

Schnepf

et al. 2020

Front. Environ. Sci.

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Microplastics (MP) are pervasive in the environment. There is ample evidence of negative MP effects on biota in aquatic ecosystems, though little is known about MP effects in terrestrial ecosystems. Given numerous entry routes of MP into soils, soil organisms are likely to be exposed to MP. We compared potential toxicological effects of MP from (i) low-density polyethylene (LDPE) (mean diameter ± standard deviation: 57 ± 40 µm) and (ii) a blend of biodegradable polymers polylactide (PLA) and poly(butylene adipateco-terephthalate) (PBAT) (40 ± 31 µm) on the reproduction and body length of the soil-dwelling bacterivorous nematode Caenorhabditis elegans. Feed suspensions without (control) or with MP (treatments) at concentrations of 1, 10, and 100 mg MP L −1 were prepared and nematodes were exposed to those suspensions on agar plates until completion of their reproductive phase (∼6 days). Using Nile red-stained PLA/PBAT MP particles and fluorescence microscopy, we demonstrated the ingestion of MP by C. elegans into pharynges and intestines. Under MP exposure, nematodes had fewer offspring (up to 22.9%) compared to nematodes in the control group. This decline was independent on the plastic type. We detected a tendency toward greater decreases in offspring at higher concentrations. Despite hints of negative effects on nematode body length under MP exposure, we could not derive a consistent pattern. We conclude that in MP-contaminated soils, the reproduction of nematodes, central actors in the soil food web, can be affected, with potentially negative implications for key soil functions, e.g., the regulation of soil biogeochemical cycles.

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A review of toxicity induced by persistent organic pollutants (POPs) and endocrine-disrupting chemicals (EDCs) in the nematode Caenorhabditis elegans

Cited by 97 publications

References 46 publications

An Orthologue of the Retinoic Acid Receptor (RAR) Is Present in the Ecdysozoa Phylum Priapulida

An Orthologue of the Retinoic Acid Receptor (RAR) Is Present in the Ecdysozoa Phylum Priapulida

Toxic Effects of Domoic Acid on Caenorhabditis elegans and the Underlying Mechanism

Microplastics Effects on Reproduction and Body Length of the Soil-Dwelling Nematode Caenorhabditis elegans

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