A Review of Traditional Japanese Medicines and their Potential Mechanism of Action

Uezono, Yasuhito; Miyano, Kanako; Sudo, Yuka; Suzuki, Masami; Shiraishi, Seiji; Terawaki, Kiyoshi

doi:10.2174/138161212803216924

Cited by 30 publications

(49 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Here we focused on Japanese traditional herbal medicine (Kampo) as an immune adjuvant for tumor vaccine. Currently, Kampo is used in a number of clinical situations such as cancer therapy, and contributes to health care (23)(24)(25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

Takeno

Inujima

Shinohara

et al. 2015

International Journal of Oncology

View full text Add to dashboard Cite

Japanese traditional herbal medicine (Kampo) have been used to improve the general physical condition after surgery and to mitigate the side effects of radiation and chemotherapy in tumor patients. Juzentaihoto (JTT) consists of ten medical herbs, and is also called Shi-Quan-Da-Bu-Tang in Chinese herbal medicine. Among Kampo medicines, JTT has especially gained attention as a biological response modifier. Currently, clinical trials of various tumor vaccine therapies are being performed world-wide. However, tumor antigens that are inoculated as vaccines do not have high immunogenicity; thus, it is difficult to obtain an effective therapeutic effect. Thus, it is necessary to develop a tumor vaccine adjuvant that is more potent and very safe. In the present study, we examined the efficacy of JTT as an oral adjuvant when given together with tumor vaccines. As a result, JTT enhanced the phagocytic ability of OVA antigen and the presentation ability of OVA antigen in dendritic cells in vitro. Furthermore, tumor growth was markedly decreased, and the survival period was significantly prolonged in mice inoculated with mouse lymphoma, which is expressed with tumor model antigen. In conclusion, these findings suggest that JTT can be used with tumor vaccines as an immune adjuvant.

show abstract

Section: Discussionmentioning

confidence: 99%

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

Takeno

Inujima

Shinohara

et al. 2015

International Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…Recently, the biological effects of Kampo medicine have received much attention, and a number of studies support the efficacy and safety of several Kampo medicines in many fields [22]. For instance, hochuekkito has various biological effects such as increasing immunity [11, 12].…”

Section: Discussionmentioning

confidence: 99%

Hochuekkito (TJ-41), a Kampo Formula, Ameliorates Cachexia Induced by Colon 26 Adenocarcinoma in Mice

Yae

Takahashi

Yae

et al. 2012

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Cachexia, a major cause of cancer-related death, is characterized by depletion of muscle and fat tissues, anorexia, asthenia, and hypoglycemia. Recent studies indicate that secretions of proinflammatory cytokines such as interleukin-6 (IL-6) play a crucial role in cachexia development, and that these cytokines are secreted from not only cancer cells but also host cells such as macrophages. In this study, we investigated the therapeutic effects of hochuekkito, a Kampo formula, on cachexia induced by colon 26 adenocarcinoma in mice. Hochuekkito treatment did not inhibit tumor growth, but significantly attenuated the reduction in carcass weight, food and water intake, weight of the gastrocnemius muscle and fat tissue around the testes, and decrease of serum triglyceride level compared with controls. Furthermore, hochuekkito treatment significantly reduced serum IL-6 level and IL-6 expression level in macrophages in tissues surrounding the tumor. In vitro studies showed that hochuekkito suppressed the production of IL-6 by THP-1 or RAW264.7 macrophage cells, although it did not affect IL-6 production by colon 26 carcinoma cells. These results suggest that hochuekkito inhibits the production of proinflammatory cytokines, particularly IL-6, by host cells such as macrophages. Therefore, hochuekkito may be a promising anticachectic agent for the treatment of patients with cancer.

show abstract

“…Hangeshashinto (HST), a traditional Japanese medicine (Kampo medicine), contains the extracted ingredients of seven medicinal herbs and has been approved by Japan's Ministry of Health, Labour and Welfare as a prescribed medicine 15,21 . From the 16th century to the present, HST has been used in Japan to treat inflammatory diarrhoea, gastritis, and oral mucositis.…”

mentioning

confidence: 99%

The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis

Miyano¹,

Eto

Hitomi

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

chemotherapy often induces oral ulcerative mucositis (oUM) in patients with cancer, characterized by severe painful inflammation. Mouth-washing with the Japanese herbal medicine hangeshashinto (HST) ameliorates chemotherapy-induced OUM in patients with colorectal cancer. Previously, we demonstrated that HST decreased interleukin 1β-induced prostaglandin E2 production in human oral keratinocytes (HOKs) and OUM-induced mechanical or spontaneous pain in rats. However, HST effects on tissue repair functions in HOKs remain unclear. Here, we examined the effects of HST on scratchinduced wound healing in vitro and in vivo. In vitro, HSt enhanced wound healing mainly through scratch-induced HOK migration. Screening of the seven constituent medicinal herbs and their major components revealed that Scutellaria root, processed ginger, and Glycyrrhiza components mainly induced the scratch-induced HOK migration. Pharmacokinetic analyses indicated that the active ingredient concentrations in rat plasma following oral HST administration were below the effective doses for HOK migration, suggesting direct effects of HST in OUM. Mitogen-activated protein kinase and C-X-C chemokine receptor 4 inhibitors significantly suppressed HST-induced HOK migration. Moreover, HST enhanced tissue repair in our OUM rat model. Thus, HST likely enhanced OUM tissue repair through oral keratinocyte migration upon MAPK and CXCR4 activation and may be useful in patients with cancer-associated OUM. Patients with cancer receiving chemotherapy, radiotherapy, hematopoietic stem cell transplant, and terminal care often present with severe oral ulcerative mucositis (OUM), which evokes painful inflammation and limits fundamental life behaviours such as 'eating, drinking, and talking' 1-15. In addition, OUM increases the risk of systemic infection via opportunistic microorganisms, which may lead to the extension of hospitalization 5,15-19. OUM also often induces patients with cancer to discontinue/modify their therapy regimen, which adversely affects patient prognosis 13,15,16,20. Therefore, the effective management of OUM is indispensable for improving both the quality of life and prognosis for the patient 15 .

show abstract

A Review of Traditional Japanese Medicines and their Potential Mechanism of Action

Cited by 30 publications

References 0 publications

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model

Hochuekkito (TJ-41), a Kampo Formula, Ameliorates Cachexia Induced by Colon 26 Adenocarcinoma in Mice

The Japanese herbal medicine Hangeshashinto enhances oral keratinocyte migration to facilitate healing of chemotherapy-induced oral ulcerative mucositis

Contact Info

Product

Resources

About