A Review of Traditional Uses, Phytochemicals and Bioactivities of the Genus Hypoestes.

Abstract

Background: Plants have been used as a folkloric source of medicinal agents since the beginning of mankind. The genus Hypoestes (family Acanthaceae) includes over 150 species. The ethno-pharmacological studies of the plant belonging to this genus indicated that they possess various bioactivities as cytotoxic, anti-leismanial, antimicrobial, antimalarial, antioxidant, and anti-trypanosomal. Furthermore, they have been utilized in different traditional medicines for treating various aliments as eye sores, breast, liver, heart, and skin diseases, respiratory infections, anemia, malaria, scabies, typhoid, hypertension, and gonorrhea. This review focuses on the traditional uses, chemical constituents, and bioactivities of Hypoestes species. Methods: The information was acquired from a literature searching in electronic databases such as ScienceDirect, PubMed, Google-Scholar, SpringerLink, Scopus, and Wiley up to 2017 for publications on genus Hypoestes. Results: The genus Hypoestes had varied classes of chemical constituents, including diterpenoids, alkaloids, lignans, and pentacyclic triterpenes. Herein, 46 metabolites and more than 30 references have been cited. Conclusion: This works provides a background for the future studies on Hypoestes species, particularly the species, which have not been extensively explored for separation and characterization of bioactive constituents and pharmacological potentials.

Dietary Diterpenoids

“…Hypoestes forscalei is a rich source of fusicoccane diterpenoids. Al Haidari (2018) reported the biotransformation of hypoestenone (59d) by fungous, Mucor ramannianus ATCC 9628. An epoxidation occurred in this case to give 8α,9α-epoxyhypoestenone (59e) (Fig.…”

Citrus essential oils as biologically active substances in the human health preventive care

“…Essential oils of the citrus genus are widely used as flavoring ingredients in the food and alcoholic beverages, cosmetic and perfume industries [9]. It was found that extracts of various parts, essential oil of fruits and some pure compounds have biological activity, for example, repellent, antimicrobial, antioxidant and antitumor properties [10,11].…”

Antimalarial Activity of Fagaropsis angolensis (Rutaceae) Crude Extracts and Solvent Fractions of Its Stem Bark Against Plasmodium berghei in Mice

“…[17][18][19] Moreover, previous reports in literature indicated that F. angolensis possessed antimicrobial, anticancer, anti-leishmanial, antifungal, and anti-trypanosomal activities. [20][21][22][23][24] Most importantly, some studies revealed that the aqueous and methanolic stem bark extracts of F. angolensis showed significant in vitro anti-plasmodial activity against both chloroquine-resistant and chloroquine-sensitive strains of P. falciparum. [25][26][27] Therefore, the present study was initiated to investigate the antimalarial activity of the stem bark extract of F. angolensis in Plasmodium bergheiinfected mice and its antioxidant activity.…”