A Review of Treatment, Risk Factors, and Incidence of Colorectal Cancer

Alaryani, Fatima S.; Alrdahe, Salma Saleh

doi:10.22159/ijap.2022v14i1.42820

Cited by 3 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The high body mass index is one of the causes of about one-third of cancer deaths [3,14]. In addition, one of the obesity consequences is insulin resistance, which contributes to colorectal progress [15]. Universally, chemotherapy is the main treatment of colorectal (colon cancer), which is one of the most prevalent cancers [14].…”

Section: Introductionmentioning

confidence: 99%

Uplc-Hr-Esi-MS Analysis and Antiproliferative and Anti-Diabesity Screening of Flowers, Roots, and Aerial Parts of Solanum Elaeagnifolium Cav.

AL-HAMAIDEH

2023

Int J App Pharm

View full text Add to dashboard Cite

Objective: Solanum elaeagnifolium Cav. is an invasive summer-growing wild perennial herb but is traditionally used to treat some health conditions, including toothache and constipation. This study aimed to identify the chemical composition of various parts of this herb (flowers, roots, and aerial parts) and explore its biological properties. Methods: Ultra-Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) was used for the first time for the root to analyze the hydro-alcoholic extract besides flowers and aerial parts of S. elaeagnifolium. Sulforhodamine B (SRB) assay was used to assess the antiproliferative effects of the same extracts on the colorectal cancer cell lines (CACO2, SW620, HT29, and HCT116). The aqueous extracts of the plant’s three parts were evaluated in vitro for their anti-diabesity properties. Results: For the first time, other compounds in three plant parts were identified using UPLC-MS: hyperoside and apigenin (flavonoids), in flowers and roots, naringin (flavonoid) in the roots, and apigenin (flavonoid) in aerial parts, diosgenin (steroids sapogenin) solamargine, and solasodine (alkaloids) in the three parts. In addition to the previously identified compounds; chlorogenic acid and kaempferol were in the aerial part, and flowers; and luteolin (flavonoids) were in the aerial parts. Pharmacologically, the aqueous extracts of flowers and roots proved anti-diabesity activity, and no anti-proliferative effect was detected for their hydro-alcoholic extracts. Neither anti-obesity nor anti-proliferative activities were detected in the aerial part extracts. Conclusion: Further in vivo and in vitro investigations are required for the different parts of S. elaeagnifolium to explore more biological activities and evaluate the plant’s toxicity.

show abstract

Section: Introductionmentioning

confidence: 99%

Uplc-Hr-Esi-MS Analysis and Antiproliferative and Anti-Diabesity Screening of Flowers, Roots, and Aerial Parts of Solanum Elaeagnifolium Cav.

AL-HAMAIDEH

2023

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…The main ways to diagnose PC include measuring the concentration of prostate-specific antigen in the serum (PSA), rectal examination, and Tran's rectal Ultrasonography biopsy [21,22]. PSA blood tests are the most common method of early detection and diagnosis of PC; but because the specificity is low, it is not reliable [23].…”

Section: Introductionmentioning

confidence: 99%

The Role of Magnetic Resonance Spectroscopy for Prostate Cancer Diagnosis

2022

View full text Add to dashboard Cite

Prostate cancer (PC) is the most common malignancy among men and is the fifth leading cause of cancer-related death in men worldwide. The present study aims to systematically review the ability of magnetic resonance spectroscopy (MRS) to differentiate between benign and malignant prostate lesions. According to the 06-PRISMA guideline, we searched in five English databases, including Scopus, PubMed, Web of Science, EMBASE, and Google Scholar without time limitation for publications related to the role of magnetic resonance spectroscopy for prostate cancer diagnosis. The searched words and terms were: “prostate cancer”, “prostatitis”, “magnetic resonance spectroscopy”, “benign prostate hyperplasia”, “malignant prostate hyperplasia”, “comparison”. Totally 1927 papers were identified by database searching. Out of these papers, 261 papers were discarded because of duplication. Of the remaining 1666 papers, 1604 papers were discarded because of the inadequate information and the ones in which the abstract was submitted in congresses as preceding papers, conferences, and editorials without full text. Out of the remaining 62 papers which were studied for eligibility, 52 papers were removed for a number of reasons including inconsistency between methods with results, incorrect interpretation of the results, poor methodology, etc. Finally, 10 papers were included in this present study. In general, based on the results of the review of articles, MRS has optimal sensitivity, specificity and accuracy in diagnosing prostate cancer and differentiating it from benign prostate hyperplasia in comparison with other diagnostic and pathological methods. Due to the small number of studies related to the sensitivity and specificity of MRS, further checking was not possible to confirm these results. Therefore, further studies in this regard are recommended.

show abstract

A Study on Intestinal Obstruction Regarding Its Epidemiology, Etiology and Management in a Peripheral Medical College

AHMAD,

BARMAN,

SINHA

et al. 2024

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objectives: The intestinal obstruction is a widespread emergency problem in our surgical practice day by day. It is a significant cause of morbidity and mortality in our health system. It is caused by adhesions, hernias, malignancies, endometriosis, inflammatory bowel disease stenosis, intussusception, and others. Our research aims to identify the etiology, epidemiology, and clinical presentations of the pathology so that we can manage the disease as early as possible for better outcomes in our peripheral institution. Methods: The study was performed on 100 cases of the age group 12–76 years admitted in the surgical ward of Midnapore Medical College and Hospital, Paschim Medinipur (W.B.) from December 2016 to June 2018. Cases of acute intestinal obstruction who underwent operation were included in our research to establish the pathology of intestinal obstruction. Results: In our study, the incidence of acute intestinal obstruction is 1.6% of total surgical cases. Maximum patients (25%) were in the age group 51– 60 years. The most common cause of intestinal obstruction was obstructed/strangulated hernia (40%). The most common symptoms were pain abdomen (88%), abdominal distension (84%), and vomiting (78%). An X-ray revealed presence of air-fluid levels in 75% of patients. The overall mortality rate was 10%. Conclusion: The morbidity and mortality of intestinal obstruction are dependent on early diagnosis, prompt resuscitation, and proper management. The critical determinants of the morbidity are age of the patient, duration of the disease, existing comorbidity, and delay in treatment. X-ray in erect view is an essential mode of diagnostic method and obstructed hernia is the most common etiology of obstruction in our research study.

show abstract

A Review of Treatment, Risk Factors, and Incidence of Colorectal Cancer

Cited by 3 publications

References 48 publications

Uplc-Hr-Esi-MS Analysis and Antiproliferative and Anti-Diabesity Screening of Flowers, Roots, and Aerial Parts of Solanum Elaeagnifolium Cav.

Uplc-Hr-Esi-MS Analysis and Antiproliferative and Anti-Diabesity Screening of Flowers, Roots, and Aerial Parts of Solanum Elaeagnifolium Cav.

The Role of Magnetic Resonance Spectroscopy for Prostate Cancer Diagnosis

A Study on Intestinal Obstruction Regarding Its Epidemiology, Etiology and Management in a Peripheral Medical College

Contact Info

Product

Resources

About