A Review of Uranium-Induced Reproductive Toxicity

Wang, Shuang; Ran, Yonghong; Lu, Binghui; Li, Juan; Kuang, Hongrong; Gong, Li; Hao, Yuhui

doi:10.1007/s12011-019-01920-2

Cited by 54 publications

(19 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, uranyl (UO 2 2+ ) as the most chemically stable species of uranium is highly soluble, making it easy to migrate in water systems. , Apart from radiotoxicity, uranium also behaves as a heavy metal with violent chemical toxicity. Excess ingestion of uranium would induce severe red blood cell reduction, DNA damage, kidney failure, and other diseases. − In consequence, real-time monitoring of uranium contamination in a water system is critical.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive and Selective Detection of Uranium by a Luminescent Terbium–Organic Framework

Lei

Jia

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Detection and remediation of radioactive components have become the focus of worldwide research interest due to the ever-increasing generation of nuclear waste and the concerns on nuclear accidents. Among the numerous radionuclides, uranium and its isotopes receive the most attention because of their high proportion in nuclear waste and long half-life. Herein, a highly luminescent terbium–organic framework, formulated as [Tb4(C29O8H17)2(NO3)4(DMF)4(H2O)4]·4H2O·8.5DMF (YTU-100), with exceptional sensitivity and selectivity toward uranium was successfully prepared. The material exhibits fast adsorption kinetics and moderate sorption capacity. Interestingly, the luminescence intensity variation highly correlates to the amount of adsorbed uranium, which results in a quantitative, accurate, and selective uranium detection manner. The detection limits in deionized water and tap water were determined to be 1.07 and 0.75 ppb, respectively, which are lower than the US Environmental Protection Agency standard of the maximum contamination of uranium in drinking water. YTU-100 offers an alternative approach for building multifunctional MOFs used for simultaneous detection and removal of uranium from aqueous solutions.

show abstract

Section: Introductionmentioning

confidence: 99%

Ultrasensitive and Selective Detection of Uranium by a Luminescent Terbium–Organic Framework

Lei

Jia

Zhang

et al. 2021

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…Infertility is a major health issue worldwide, and the impact of environmental exposure to uranium on male fertility needs to be studied in more detail. Various biological effects have already been demonstrated for the male and female reproductive functions and fertility [ 8 , 9 ]. The impact of uranium on human infertility is a major concern.…”

Section: Discussionmentioning

confidence: 99%

“…However, the impact of entropic pollution on ecosystems and human health, especially fertility, is a major concern for scientists and the public, as different pollutants have already been associated with secondary reproductive effects, e.g., endocrine disruptors [ 3 ], air pollution [ 4 , 5 , 6 ] and noise [ 7 ]. Thus, the effects of environmental exposure to radionuclides such as uranium on reproduction have become a growing societal concern [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Grison

Legendre

Svilar

et al. 2022

IJMS

View full text Add to dashboard Cite

Male infertility is a major public health issue that can be induced by a host of lifestyle risk factors such as environment, nutrition, smoking, stress, and endocrine disruptors. Regarding the human population exposed to uranium, it is necessary to explore these effects on male reproduction in multigenerational studies. The sensitivity of mass spectrometry (MS)-based methods has already proved to be extremely useful in metabolite identification in rats exposed to low doses of uranium, but also in human sperm. We applied this method to rat sperm over three generations (F0, F1 and F2) with multigenerational uranium exposure. Our results show a significant content of uranium in generation F0, and a reduction in the pregnancy rate only in generation F1. Based on principal component analysis (PCA), we observed discriminant profiles between generations. The partial least squares discriminant analysis (PLS-DA) of the 48 annotated variables confirmed that parental exposure of generation F0 (during both the preconceptional and prenatal periods) can have metabolic effects on spermatozoa for the next two generations. Metabolomics applied to epididymal spermatozoa is a novel approach to detecting the multigenerational effects of uranium in an experimental model, but could be also recommended to identify potential biomarkers evaluating the impact of uranium on sperm in exposed infertile men.

show abstract

“…While soluble uranium compounds can be excreted from the body to some extent, insoluble uranium compounds, especially in the form of dust, can be inhaled by the body and cause great harm when they adhere to the lungs [4] . In addition, uranium that enters the body becomes uranyl ions (UO 2 2+ ), which can accumulate and cause fatal damage to bones, liver, kidneys, and reproductive tissues [5] . Therefore, timely and accurate detection of trace amounts of uranium in the environment is essential for both healthy life and environmental protection [6] .…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide modified H₄L‐ion imprinting electrochemical sensor for the detection of uranyl ions

Wang

Liu

et al. 2021

Zeitschrift anorg allge chemie

View full text Add to dashboard Cite

The rapid development of the nuclear industry has gradually aroused people′s attention to the problem of nuclear pollution. Due to the biological toxicity of uranium and its aqueous solution, simple and rapid detection of uranium in the water environment is quite important. An ion imprinted carbon nanomaterial (graphene oxide) electrochemical sensor for the detection of trace uranyl ions was prepared by using the synthesized bipolar tetradentate macrocyclic uranyl ligand cyclo‐bis‐phenylenediamine‐bis‐(phenylmethyl‐diphyrrolecarbaldehyde) (H4L) as functional monomer. The sol‐gel polymer was prepared by hydrolysis and polymerization of H4L ligand, 3‐aminopropyltrimethoxysilane and tetraethoxysilane. H4L‐ion imprinted polymer (U‐IIP) was prepared by adding 1 mM uranyl ion as template ions. Then the polymer was bonded to graphene oxide modified carbon paste electrode, and the template ions were eluted to obtain H4L‐ion imprinted‐graphene oxide modified carbon paste electrode (U‐IIP/GO/CPE). Differential pulse voltammetry was used to detect trace uranyl ions. The results showed that the U‐IIP/GO/CPE sensor system can detect uranyl ions with high sensitivity and specificity, and the peak current appeared around −0.26v. In the range of 0.01 μM∼3.0 μM, the detection current had a good linear relationship with the molar concentration of uranyl ions, and the method detection limit was 1.32 nM (S/N=3). Through the detection of actual samples, it had a good acceptable recovery rate (95.45 %∼106.25 %), and the relative standard deviation was less than 3.25 %.

show abstract

A Review of Uranium-Induced Reproductive Toxicity

Cited by 54 publications

References 46 publications

Ultrasensitive and Selective Detection of Uranium by a Luminescent Terbium–Organic Framework

Ultrasensitive and Selective Detection of Uranium by a Luminescent Terbium–Organic Framework

Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Graphene oxide modified H₄L‐ion imprinting electrochemical sensor for the detection of uranyl ions

Contact Info

Product

Resources

About

A Review of Uranium-Induced Reproductive Toxicity

Cited by 54 publications

References 46 publications

Ultrasensitive and Selective Detection of Uranium by a Luminescent Terbium–Organic Framework

Ultrasensitive and Selective Detection of Uranium by a Luminescent Terbium–Organic Framework

Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Graphene oxide modified H4L‐ion imprinting electrochemical sensor for the detection of uranyl ions

Contact Info

Product

Resources

About

Graphene oxide modified H₄L‐ion imprinting electrochemical sensor for the detection of uranyl ions