A Review of Wound Healing Mechanisms of Natural Products in Keratinocyte Cells

Abstract

Background: The skin is the largest organ of the human body, around 15% of the body weight consisting of the epidermis, dermis, and subcutaneous. The skin's primary function is to protect our body from external factors that can harm the body by forming a protective barrier that covers the body. This review aims to provide insights related to wound-healing mechanisms of several plants in HaCat cells. Methods: The literature study method used, both from primary and secondary libraries. The library search was conducted using online-based library search instruments from 2009 to 2021, such as NCBI-PubMed and Google Scholar. Results: The wound-healing mechanism includes processes that restore skin integrity through four stages: hemostasis, inflammation, multiplication, and remodeling. Many plants have been studied to have activity in wound-healing by various mechanisms. Conclusions: Therefore, it is essential to research wound-healing mechanisms to find treatments sourced from natural compounds.