A review on 1,4-dihydropyridines as anti-tuberculosis agent

Tandem Protocol of Hexahydroquinoline Synthesis Using [H2-DABCO][HSO4]2 Ionic Liquid as a Green Catalyst at Room Temperature

“…1,4-Dihydropyridine (1,4-DHP) nuclei are key fragments in various natural compounds as well as in synthetic molecules because of their interaction properties with different proteins . Since 1,4-DHP is an analogue of the coenzyme NADH (nicotinamide adenine dinucleotide), biochemists are highly attracted toward its green synthesis with its applications in medicinal chemistry. − The 1,4-DHP skeleton works as a calcium channel modulator and cardiovascular agent (nicardipine, amlodipine, and nifedipine) and shows antitubercular, antitumor, antiatherosclerotic, vasodilator, neuroprotective, hepatoprotective, and bronchodilator activity. − Polyhydroquinoline (PHQ) is a derivative of 1,4-DHP, a large family of medicinal and industrially important compounds, and has fascinated researchers…”