A Review on 2‐Heteryl and Heteroalkyl‐4(3H)‐quinazolinones

Abstract

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Design, Synthesis, Docking and Antitumor Activity of Quinazolino [3, 4‐a] thieno [3, 2‐d] pyrimidin‐8‐one Derivatives

“…The quinazolones substructure has been found in many plant and microbial metabolites as part of complex molecules such as febrifugine, methaqualon, rutaecarpine, (‐) vasicinone and luotonin A–F that possess a quinazolinone moiety and fuse with indolopyrido and pyrrolloquinoline ring systems, respectively (1–3). Mostof these molecules have pronounced biologic activities, and are used as fungicides, anti‐inflammatory, anticancer, abirritant and antihypertensive agents (4–12). We report here the design, synthesis and antitumor activity of quinazolino [3, 4‐a] thieno [3, 2‐d] pyrimidin‐8‐one derivatives with different substituents at the position of the side chain, which also have quinazolones skeleton.…”