2017
DOI: 10.1002/jat.3464
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A review on acridinylthioureas and its derivatives: biological and cytotoxic activity

Abstract: Acridines possess two characteristics that have led many researchers to consider the agents interesting targets for future development as potential farmacophores: the planar acridine skeleton, which is able to intercalate into DNA, and the intense fluorescence of the agents. This review offers a study of the multifunctional character of acridines and the synthesis of novel acridine derivatives, with particular focus being placed on isothiocyanates and their congeners, e.g. thioureas, isothioureas, quaternary a… Show more

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Cited by 26 publications
(26 citation statements)
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“…Nowadays, the most common acridine derivative is amsacrine, which is used as antineoplastic agents in the treatment of leukaemia. Moreover, researchers around the world have studied novel acridine derivatives against various cancers [11][12][13][14][15][16][17]. The mechanism of action of acridine derivatives involves intercalation into DNA in the space between two base pairs, due to the planar polycyclic aromatic structure.…”
Section: Introductionmentioning
confidence: 99%
“…Nowadays, the most common acridine derivative is amsacrine, which is used as antineoplastic agents in the treatment of leukaemia. Moreover, researchers around the world have studied novel acridine derivatives against various cancers [11][12][13][14][15][16][17]. The mechanism of action of acridine derivatives involves intercalation into DNA in the space between two base pairs, due to the planar polycyclic aromatic structure.…”
Section: Introductionmentioning
confidence: 99%
“…Acridines are important organic compounds with potent biological properties, [1][2][3] which are in focus of our longterm research. The hydrazide-hydrazone fragment CH═N─NH─CO represents a significant structural unit with a wide range of biological activities such as antitumor, [4,5] antimicrobial, [6] anti-inflammatory, [7] and antituberculotic.…”
Section: Introductionmentioning
confidence: 99%
“…Thiourea, H 2 NC(=S)NH 2 , is susceptible for to up to four substitutions to give a wide range of compounds, R 1 (R 2 )NC(=S)N(R 3 )R 4 for R [1][2][3][4] = alkyl/aryl [1]. These molecules can possess interesting properties and are well known for their ability to complex metal ions [1].…”
Section: Introductionmentioning
confidence: 99%
“…These molecules can possess interesting properties and are well known for their ability to complex metal ions [1]. Recent interest in thiourea derivatives revolves around their applications in dual hydrogen bonding catalysis for asymmetric synthesis [2,3] and for their potential biological potency [4], including when complexing metals [5]. Indeed, the original interest in the title compound 1-[N-methyl-N-(phenyl)amino]-3-(4-methylphenyl)thiourea (1), Scheme 1, related to the investigation of antiviral activity [6]; since then there have been no other reports of (1) in the literature.…”
Section: Introductionmentioning
confidence: 99%