A review on allopathic and herbal nanofibrous drug delivery vehicles for cancer treatments

Mateti, Tarun; Aswath, Surabhi; Vatti, Anoop Kishore; Kamath, Agneya; Laha, Anindita

doi:10.1016/j.btre.2021.e00663

Cited by 28 publications

(12 citation statements)

References 82 publications

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“…In other words, the hydrophilic polymers have been shown to accelerate the rate of DNA release by forming water channels within the matrix. Recent studies [32][33][34] have reported the ability of copolymers containing PLA and PEG components to control drug release, which is in support of the results of this study. The ability to penetrate and transport PLA-PEG/Chitosan-FA/DNA nanoparticles into MCF-7 cells was demonstrated using uorescent microscopy images (Fig.…”

Section: Discussionsupporting

confidence: 90%

“…Given that the premise for gene transfer by these nanocarriers is dependent on the phenomena of endocytosis, and that intracellular nucleases destroy more than 99 percent of the DNA entering the cell, as a result, in gene therapy research, protecting DNA from harmful enzymes is critical [33]. Previous studies have demonstrated that polycations constitute a physical barrier to restriction enzyme binding due to their complexation with DNA, therefore shielding DNA from digestion by these enzymes [34].The ability of PLA-PEG/Chitosan-FA/DNA nanoparticles to penetrate and safely release DNA into MCF-7 cells was demonstrated by uorescent microscopy images of MCF-7 cells treated with these nanoparticles (Fig. 4, E).…”

Section: Discussionmentioning

confidence: 99%

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Preparation and characterization of PLA-PEG/Chitosan-FA/DNA for gene transfer to MCF-7 cells

Afrouz

Ahmadi-Nouraldinvand

ajirlu

et al. 2022

Preprint

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The ability of Chitosan-Folic acid and PLA-PEG polymers for gene delivery into MCF-7 cells was evaluated. The PLA-PEG copolymer is one of the most appealing nanoparticles for gene transfer to human cells because of its biocompatibility and high blood circulation. However, one of the barriers to the use of these polymers in gene therapy has always been the low effectiveness of these nanoparticles. In this study, Chitosan and folic acid were utilized to improve gene transfer efficiency and encapsulation of PLA-PEG/Chitosan-FA/DNA nanoparticles. PLA-PEG/Chitosan-FA/DNA nanoparticles with different concentrations of Chitosan-FA were prepared using double emulsion-solvent evaporation technique. The biological properties (i.e., biocompatibility, DNA release, and gene transfer ability to MCF-7 cells in vitro) as well as the physical and chemical properties (i.e., particle size, zeta potential, and the morphology of the resultant nanoparticles) of PLA-PEG/Chitosan-FA/DNA nanoparticles were investigated. The results showed that increasing the Chitosan-FA concentration in the PLA-PEG/Chitosan-FA/DNA nanoparticles resulted in an increase in zeta potential, DNA release, encapsulation, and gene delivery efficiency. The MTT assay showed PLA-PEG/Chitosan-FA/DNA nanoparticles exhibit low cytotoxicity and good compatibility. On the other hand, fluorescence microscopy and flow cytometry were used to test the ability of PLA-PEG/Chitosan-FA/DNA nanoparticles with varied concentrations of chitosan-folic acid to transfer the gene to MCF-7 cells. Flow cytometry and fluorescence microscopy analysis showed that increasing the concentration of chitosan-folic acid in PLA-PEG/Chitosan-FA/DNA nanoparticles improved gene transfer efficiency to MCF-7 cells.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Preparation and characterization of PLA-PEG/Chitosan-FA/DNA for gene transfer to MCF-7 cells

Afrouz

Ahmadi-Nouraldinvand

ajirlu

et al. 2022

Preprint

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“…Nanotechnology is the novel and targeted drug delivery system for treatment of cancer and the future of medical science. Nanostructures including nanoparticles, liposomes, dendrimers, and micelles have been employed as controlled delivery systems for the treatment of cancer [ 4 ]. For many years, herbal remedies have been used and are still used as the primary form of healthcare in developing countries.…”

Section: Introductionmentioning

confidence: 99%

Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook

Gaikwad

Morade

Kothule

et al. 2023

Heliyon

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“…Several investigations have combined the as-synthesized magnetic nanoparticles with various polymers to produce composite nanofibers through electrospinning [ 30 , 31 ]. In this study, we emphasized the fabrication of nanofibers embedded with magnetic particles of two distinct kinds, which provide different magnetic responses depending on the required applications.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Response of Nano/Microparticles into Elastomeric Electrospun Fibers

Iannotti

Ausanio

Ferretti³

et al. 2023

JFB

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Combining magnetic nanoparticles (MNPs) with high-voltage processes to produce ultra-thin magnetic nanofibers (MNFs) fosters the development of next-generation technologies. In this study, polycarbonate urethane nanofibers incorporating magnetic particles were produced via the electrospinning technique. Two distinct types of magnetic payload were used: (a) iron oxide nanoparticles (IONPs) with an average size and polydispersity index of 7.2 nm and 3.3%, respectively; (b) nickel particles (NiPs) exhibiting a bimodal size distribution with average sizes of 129 nanometers and 600 nanometers, respectively, and corresponding polydispersity indexes of 27.8% and 3.9%. Due to varying particle sizes, significant differences were observed in their aggregation and distribution within the nanofibers. Further, the magnetic response of the IONP and/or NiP-loaded fiber mats was consistent with their morphology and polydispersity index. In the case of IONPs, the remanence ratio (Mr/Ms) and the coercive field (Hc) were found to be zero, which agrees with their superparamagnetic behavior when the average size is smaller than 20–30 nm. However, the NiPs show Mr/Ms = 22% with a coercive field of 0.2 kOeas expected for particles in a single or pseudo-single domain state interacting with each other via dipolar interaction. We conclude that magnetic properties can be modulated by controlling the average size and polydispersity index of the magnetic particles embedded in fiber mats to design magneto-active systems suitable for different applications (i.e., wound healing and drug delivery).

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A review on allopathic and herbal nanofibrous drug delivery vehicles for cancer treatments

Cited by 28 publications

References 82 publications

Preparation and characterization of PLA-PEG/Chitosan-FA/DNA for gene transfer to MCF-7 cells

Preparation and characterization of PLA-PEG/Chitosan-FA/DNA for gene transfer to MCF-7 cells

Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook

Magnetic Response of Nano/Microparticles into Elastomeric Electrospun Fibers

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