A review on ameliorative green nanotechnological approaches in diabetes management

Bhardwaj, Monika; Yadav, Poonam; Dalal, Sunita; Kataria, Sudhir Kumar

doi:10.1016/j.biopha.2020.110198

Cited by 33 publications

(16 citation statements)

References 99 publications

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“…Pregnant women who experienced a decrease in Hb levels after consuming moringa leaf extract could also be due to the characteristics of the respondents who were all in the second trimester of pregnancy. In this trimester, there is a risk of physiologic anemia caused by increased blood which is commonly called hydremia or hypervolemia (18). In fact, the increase in blood cells is less than the increase in plasma resulting in blood-thinning.…”

Section: Discussionmentioning

confidence: 99%

effect of moringa leaf extract in increasing Hb levels of pregnant women during COVID-19 pandemic in Parigi Regency, Central Sulawesi, Indonesia

Nur

Demak

Yane

2022

ijhs

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Background; The Covid-19 pandemic has a major impact on socioeconomic conditions and public health, especially pregnant women. The availability of food and nutrition will be greatly reduced due to limited mobility which will have an impact on the incidence of anemia in pregnant women. Thus, it is important to use moringa leaf extract as a local resource. Aim To find out the effect of Moringa leaf extract in reducing the incidence of anemia (hemoglobin levels) in pregnant women during the Covid-19 pandemic in the work area of Siniu, Community Health Center, Parimo Regency. Method It is a quasi-experimental research with randomized controlled Double-Blind design. The sample included 40 pregnant women divided into two groups: 20 pregnant women in the intervention group and 20 pregnant women in the control group. The intervention group was given moringa leaf extract capsule and Fe capsule every day. The control group was only given Fe capsule. Result The results showed that the characteristics of the respondents in the two groups before intervention were not different P=0.106. After the intervention for 1 month, the HB level of pregnant women in the intervention group increased significantly compared to the control group (p=0.050).

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Section: Discussionmentioning

confidence: 99%

effect of moringa leaf extract in increasing Hb levels of pregnant women during COVID-19 pandemic in Parigi Regency, Central Sulawesi, Indonesia

Nur

Demak

Yane

2022

ijhs

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“…Among these 37 confirmed hits, 16 were saponin-like molecules with complex structures (ophiopogonin B, asparanin B and calenduloside E, G) [64][65][66][67], with molecular weights ranging from 620 to 1,833 g/mol (S4 Table in S1 File). Most of these molecules are relatively uncharacterized, with some previous studies demonstrating that they had a wide range of biological activities along with low toxicities and some degree of anti-tumor, antiviral [68] and anti-diabetes activities [69]. We were unable to explore this group of compounds further due to their limited availability.…”

Section: Compound Hit Confirmation In Orthogonal Assays: Mcherry-zikvmentioning

confidence: 99%

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

et al. 2022

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The global health emergency posed by the outbreak of Zika virus (ZIKV), an arthropod-borne flavivirus causing severe neonatal neurological conditions, has subsided, but there continues to be transmission of ZIKV in endemic regions. As such, there is still a medical need for discovering and developing therapeutical interventions against ZIKV. To identify small-molecule compounds that inhibit ZIKV disease and transmission, we screened multiple small-molecule collections, mostly derived from natural products, for their ability to inhibit wild-type ZIKV. As a primary high-throughput screen, we used a viral cytopathic effect (CPE) inhibition assay conducted in Vero cells that was optimized and miniaturized to a 1536-well format. Suitably active compounds identified from the primary screen were tested in a panel of orthogonal assays using recombinant Zika viruses, including a ZIKV Renilla luciferase reporter assay and a ZIKV mCherry reporter system. Compounds that were active in the wild-type ZIKV inhibition and ZIKV reporter assays were further evaluated for their inhibitory effects against other flaviviruses. Lastly, we demonstrated that wild-type ZIKV is able to infect a 3D-bioprinted outer-blood-retina barrier tissue model and disrupt its barrier function, as measured by electrical resistance. One of the identified compounds (3-Acetyl-13-deoxyphomenone, NCGC00380955) was able to prevent the pathological effects of the viral infection on this clinically relevant ZIKV infection model.

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“…Monometallic as well as bimetallic NPs have been reported to be efficient anti-cancerous agents as they induce apoptosis via ROS burst [11]. Plant mediated NPs with bioactive compounds capped over them have several benefits over chemical drugs, including efficacy at lower concentrations, target specificity, and the ability to cross the blood-brain barrier [12]. NPs also display anti-aging activity by inhibiting the formation of advanced glycation end products (AGEs) by competing with carbohydrates in binding with extra-cellular matrix proteins [13].…”

Section: Introductionmentioning

confidence: 99%

Light Tailoring: Impact of UV-C Irradiation on Biosynthesis, Physiognomies, and Clinical Activities of Morus macroura-Mediated Monometallic (Ag and ZnO) and Bimetallic (Ag–ZnO) Nanoparticles

Anjum

Khan

Qamar

et al. 2021

IJMS

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A nano-revolution based on the green synthesis of nanomaterials could affect all areas of human life, and nanotechnology represents a propitious platform for various biomedical applications. During the synthesis of nanoparticles, various factors can control their physiognomies and clinical activities. Light is one of the major physical factors that can play an important role in tuning/refining the properties of nanoparticles. In this study, biocompatible monometallic (AgNPs and ZnONPs) and bimetallic Ag–ZnONPs (0.1/0.1 and 0.1/0.5) were synthesized under UV-C light irradiation from the leaf extract of Morus macroura, which possesses enriched TPC (4.238 ± 0.26 mg GAE/g DW) and TFC (1.073 ± 0.18 mg QE/g DW), as well as strong FRSA (82.39%). These green synthesized NPs were evaluated for their anti-diabetic, anti-glycation, and biocompatibility activities. Furthermore, their anti-cancerous activity against HepG2 cell lines was assessed in terms of cell viability, production of reactive oxygen/nitrogen species, mitochondrial membrane potential, and apoptotic caspase-3/7 expression and activity. Synthesized NPs were characterized by techniques including ultraviolet-visible spectroscopy, SEM, EDX, FTIR, and XRD. UV-C mediated monometallic and bimetallic NPs showed well-defined characteristic shapes with a more disperse particle distribution, definite crystalline structures, and reduced sizes as compared to their respective controls. In the case of clinical activities, the highest anti-diabetic activity (67.77 ± 3.29% against α-amylase and 35.83 ± 2.40% against α-glucosidase) and anti-glycation activity (37.68 ± 3.34% against pentosidine-like AGEs and 67.87 ± 2.99% against vesperlysine-like AGEs) was shown by UV-C mediated AgNPs. The highest biocompatibility (IC50 = 14.23 ± 1.68 µg/mL against brine shrimp and 2.48 ± 0.32% hemolysis of human red blood cells) was shown by UV-C mediated ZnONPs. In the case of anti-cancerous activities, the lowest viability (23.45 ± 1.40%) with enhanced ROS/NOS production led to a significant disruption of mitochondrial membrane potential and greater caspase-3/7 gene expression and activity by UV-C mediated bimetallic Ag–ZnONPs (0.1/0.5). The present work highlights the positive effects of UV-C light on physico-chemical physiognomies as well as the clinical activities of NPs.

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A review on ameliorative green nanotechnological approaches in diabetes management

Cited by 33 publications

References 99 publications

effect of moringa leaf extract in increasing Hb levels of pregnant women during COVID-19 pandemic in Parigi Regency, Central Sulawesi, Indonesia

effect of moringa leaf extract in increasing Hb levels of pregnant women during COVID-19 pandemic in Parigi Regency, Central Sulawesi, Indonesia

A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model

Light Tailoring: Impact of UV-C Irradiation on Biosynthesis, Physiognomies, and Clinical Activities of Morus macroura-Mediated Monometallic (Ag and ZnO) and Bimetallic (Ag–ZnO) Nanoparticles

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