A review on anticancer applications of pullulan and pullulan derivative nanoparticles

Ganie, Showkat Ali; Rather, Luqman Jameel; Li, Qing

doi:10.1016/j.carpta.2021.100115

Cited by 25 publications

(17 citation statements)

References 160 publications

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“…Compared to other polysaccharides, the aqueous pullulan solution is stable and has a relatively low viscosity. Due to its advantageous properties, such as biodegradability, biocompatibility, non-immunogenicity, non-toxicity, non-mutagenicity, and non-carcinogenicity, pullulan is an important biomaterial for the preparation of nanoparticles based on natural polysaccharides, applicable for various biomedical use [ 61 , 111 , 249 , 250 , 251 ]. Pullulan-based nanoparticles are nanocarriers for various therapeutic substances, for example, antimicrobial agents and essential oils with inhibitory activity against pathogenic Gram-negative and Gram-positive bacteria and fungi, including multidrug-resistant and biofilm-forming bacteria [ 252 ].…”

Section: Fungal-based Biopolymeric Nanoparticles Used For Healthcare ...mentioning

confidence: 99%

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Kučuk

Primožič

Knez

et al. 2023

IJMS

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Biopolymeric nanoparticles are gaining importance as nanocarriers for various biomedical applications, enabling long-term and controlled release at the target site. Since they are promising delivery systems for various therapeutic agents and offer advantageous properties such as biodegradability, biocompatibility, non-toxicity, and stability compared to various toxic metal nanoparticles, we decided to provide an overview on this topic. Therefore, the review focuses on the use of biopolymeric nanoparticles of animal, plant, algal, fungal, and bacterial origin as a sustainable material for potential use as drug delivery systems. A particular focus is on the encapsulation of many different therapeutic agents categorized as bioactive compounds, drugs, antibiotics, and other antimicrobial agents, extracts, and essential oils into protein- and polysaccharide-based nanocarriers. These show promising benefits for human health, especially for successful antimicrobial and anticancer activity. The review article, divided into protein-based and polysaccharide-based biopolymeric nanoparticles and further according to the origin of the biopolymer, enables the reader to select the appropriate biopolymeric nanoparticles more easily for the incorporation of the desired component. The latest research results from the last five years in the field of the successful production of biopolymeric nanoparticles loaded with various therapeutic agents for healthcare applications are included in this review.

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Section: Fungal-based Biopolymeric Nanoparticles Used For Healthcare ...mentioning

confidence: 99%

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Kučuk

Primožič

Knez

et al. 2023

IJMS

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“…Au NPs with a large surface area can be deployed as effective platforms for therapeutic agents, allowing for the efficient binding of targeting agents and drugs. In one study, Au nanomaterials stabilized by pullulan were coupled with 5-fluorouracil and folic acid for targeted drug delivery and cancer imaging [ 28 , 51 ]. These nanosystems can be delivered to the cells via active or passive target delivery approaches.…”

Section: Therapeutics and Diagnosticsmentioning

confidence: 99%

Functionalized Silver and Gold Nanomaterials with Diagnostic and Therapeutic Applications

et al. 2022

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The functionalization of nanomaterials with suitable capping ligands or bioactive agents is an interesting strategy in designing nanosystems with suitable applicability and biocompatibility; the physicochemical and biological properties of these nanomaterials can be highly improved for biomedical applications. In this context, numerous explorations have been conducted in the functionalization of silver (Ag) and gold (Au) nanomaterials using suitable functional groups or agents to design nanosystems with unique physicochemical properties such as excellent biosensing capabilities, biocompatibility, targeting features, and multifunctionality for biomedical purposes. Future studies should be undertaken for designing novel functionalization tactics to improve the properties of Au- and Ag-based nanosystems and reduce their toxicity. The possible release of cytotoxic radicals or ions, the internalization of nanomaterials, the alteration of cellular signaling pathways, the translocation of these nanomaterials across the cell membranes into mitochondria, DNA damages, and the damage of cell membranes are the main causes of their toxicity, which ought to be comprehensively explored. In this study, recent advancements in diagnostic and therapeutic applications of functionalized Au and Ag nanomaterials are deliberated, focusing on important challenges and future directions.

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“…Pharmaceutical applications of polysaccharide NPs involve targeted drug release [143], in vivo drug delivery [144], and stabilizing cosmetic ingredients (e.g., skin and hair care) [145], gene delivery [146], and vaccine delivery [147] as a result of their biodegradability, biocompatibility, muco-adhesive properties, and cellular uptake [148,149]. Cell viability tests have revealed their non-cytotoxicity [150,151], whereas biomedical applications of the polysaccharide NPs involve their use as sensors for the detection of viruses and bacteria [142], tissue engineering [152], wound healing [153], tumor therapy, and delivery of anticancer agents [154].…”

Section: Polysaccharide-and Protein-based Nanoantioxidantsmentioning

confidence: 99%

Nanoantioxidants: Pioneer Types, Advantages, Limitations, and Future Insights

Omran

Baek

2021

Molecules

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Free radicals are generated as byproducts of normal metabolic processes as well as due to exposure to several environmental pollutants. They are highly reactive species, causing cellular damage and are associated with a plethora of oxidative stress-related diseases and disorders. Antioxidants can control autoxidation by interfering with free radical propagation or inhibiting free radical formation, reducing oxidative stress, improving immune function, and increasing health longevity. Antioxidant functionalized metal nanoparticles, transition metal oxides, and nanocomposites have been identified as potent nanoantioxidants. They can be formulated in monometallic, bimetallic, and multi-metallic combinations via chemical and green synthesis techniques. The intrinsic antioxidant properties of nanomaterials are dependent on their tunable configuration, physico-chemical properties, crystallinity, surface charge, particle size, surface-to-volume ratio, and surface coating. Nanoantioxidants have several advantages over conventional antioxidants, involving increased bioavailability, controlled release, and targeted delivery to the site of action. This review emphasizes the most pioneering types of nanoantioxidants such as nanoceria, silica nanoparticles, polydopamine nanoparticles, and nanocomposite-, polysaccharide-, and protein-based nanoantioxidants. This review overviews the antioxidant potential of biologically synthesized nanomaterials, which have emerged as significant alternatives due to their biocompatibility and high stability. The promising nanoencapsulation nanosystems such as solid lipid nanoparticles, nanostructured lipid carriers, and liposome nanoparticles are highlighted. The advantages, limitations, and future insights of nanoantioxidant applications are discussed.

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A review on anticancer applications of pullulan and pullulan derivative nanoparticles

Cited by 25 publications

References 160 publications

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Sustainable Biodegradable Biopolymer-Based Nanoparticles for Healthcare Applications

Functionalized Silver and Gold Nanomaterials with Diagnostic and Therapeutic Applications

Nanoantioxidants: Pioneer Types, Advantages, Limitations, and Future Insights

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