A review on antimicrobial mechanism and applications of graphene-based materials

Shankar, Krishna; Agarwal, Satakshi; Mishra, Subham; Bhatnagar, Pranshul; Siddiqui, Sufiyan; Abrar, Iyman

doi:10.1016/j.bioadv.2023.213440

Cited by 16 publications

(10 citation statements)

References 161 publications

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“…The size and thickness of ZnO Nfs play a crucial role in determining the nature of this interaction with the cell. [ 20 ]…”

Section: Resultsmentioning

confidence: 99%

“…The size and thickness of ZnO Nfs play a crucial role in determining the nature of this interaction with the cell. [20] Larger slices of ZnO NSfs have been observed to interact with the cell membrane through surface area mediated interactions. These slices make contact with the membrane and arrange themselves on its surface, effectively "wrapping" the cells in a relatively isolated environment.…”

Section: Zno-nmts Reduce Cell Viabilitymentioning

confidence: 99%

“…Additionally, nanorods and nanosheets contribute to cell death mediated by oxidative stress, involving both ROS-dependent and ROS-independent mechanisms. [13][14][15][16][17][18][19][20][21][22][23] The cytotoxicity of ZnO-NMts has been demonstrated in both in vitro and in vivo studies using various mammalian cells. Different levels of toxicity have been observed on human A549 cells, human gingiva cells, zebrafish cells, HepG2 cells, and human endothelial cells.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, nanorods and nanosheets contribute to cell death mediated by oxidative stress, involving both ROS‐dependent and ROS‐independent mechanisms. [ 13–23 ]…”

Section: Introductionmentioning

confidence: 99%

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Screening of low‐toxic zinc oxide nanomaterials and study the apoptosis mechanism of NSC‐34 cells

Li,

Lu,

et al. 2024

Biotechnology Journal

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With the increasing application of ZnO nanomaterials (ZnO‐NMts) in the biomedical field, it is crucial to assess their potential risks to humans and the environment. Therefore, this study aimed to screen for ZnO‐NMts with low toxicity and establish safe exposure limits, and investigate their mechanisms of action. The study synthesized 0D ZnO nanoparticles (ZnO NPs) and 3D ZnO nanoflowers (ZnO Nfs) with different morphologies using a hydrothermal approach for comparative research. The ZnO‐NMts were characterized using X‐ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Mouse brain neuronal cells (NSC‐34) were incubated with ZnO NMts for 6, 12, and 24 h, and the cell morphology was observed using TEM. The toxic effects of ZnO Nfs on NSC‐34 cells were studied using CCK‐8 cell viability detection, reactive oxygen species (ROS) measurement, caspase‐3 activity detection, Annexin V‐FITC/PI apoptosis assay, and mitochondrial membrane potential (Δφm) measurement. The results of the research showed that ZnO‐NMts caused cytoplasmic vacuolization and nuclear pyknosis. After incubating cells with 12.5 µg mL−1 ZnO‐NMts for 12 h, ZnO NRfs exhibited the least toxicity and ROS levels. Additionally, there was a significant increase in caspase‐3 activity, depolarization of mitochondrial membrane potential (Δφm), and the highest rate of early apoptosis.This study successfully identified ZnO NRfs with the lowest toxicity and determined the safe exposure limit to be < 12.5 µg mL−1 (12 h). These findings will contribute to the clinical use of ZnO NRfs with low toxicity and provide a foundation for further research on their potential applications in brain disease treatment.

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“…The size and thickness of ZnO Nfs play a crucial role in determining the nature of this interaction with the cell. [ 20 ]…”

Section: Resultsmentioning

confidence: 99%

Section: Zno-nmts Reduce Cell Viabilitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Additionally, nanorods and nanosheets contribute to cell death mediated by oxidative stress, involving both ROS‐dependent and ROS‐independent mechanisms. [ 13–23 ]…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Screening of low‐toxic zinc oxide nanomaterials and study the apoptosis mechanism of NSC‐34 cells

Li,

Lu,

et al. 2024

Biotechnology Journal

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“…Currently, a large number of research cases on GBNs' antibacterial and fungal resistance, and a few studies on the effect of GBN treatment on bacterial and fungal diversity are reported in the literature. Many reviews on GBNs' antimicrobial effects are available [15][16][17][18][19][20]; these mainly focus on their antimicrobial mechanisms and applications. However, the literature summarizing the knowledge of GBN's effect on microbial communities is relatively limited [21,22].…”

Section: Introductionmentioning

confidence: 99%

Effects of Graphene-Based Nanomaterials on Microorganisms and Soil Microbial Communities

Cao,

Zhang,

Wang

et al. 2024

Microorganisms

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The past decades have witnessed intensive research on the biological effects of graphene-based nanomaterials (GBNs) and the application of GBNs in different fields. The published literature shows that GBNs exhibit inhibitory effects on almost all microorganisms under pure culture conditions, and that this inhibitory effect is influenced by the microbial species, the GBN’s physicochemical properties, the GBN’s concentration, treatment time, and experimental surroundings. In addition, microorganisms exist in the soil in the form of microbial communities. Considering the complex interactions between different soil components, different microbial communities, and GBNs in the soil environment, the effects of GBNs on soil microbial communities are undoubtedly intertwined. Since bacteria and fungi are major players in terrestrial biogeochemistry, this review focuses on the antibacterial and antifungal performance of GBNs, their antimicrobial mechanisms and influencing factors, as well as the impact of this effect on soil microbial communities. This review will provide a better understanding of the effects of GBNs on microorganisms at both the individual and population scales, thus providing an ecologically safe reference for the release of GBNs to different soil environments.

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Nano-sized Clays, Graphene, and Inorganic Oxides as Fillers of Nanocomposites for Their Mechanical and Barrier Properties Improvement: A Global View

Kasaai

2024

Handbook of Nanofillers

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A review on antimicrobial mechanism and applications of graphene-based materials

Cited by 16 publications

References 161 publications

Screening of low‐toxic zinc oxide nanomaterials and study the apoptosis mechanism of NSC‐34 cells

Screening of low‐toxic zinc oxide nanomaterials and study the apoptosis mechanism of NSC‐34 cells

Effects of Graphene-Based Nanomaterials on Microorganisms and Soil Microbial Communities

Nano-sized Clays, Graphene, and Inorganic Oxides as Fillers of Nanocomposites for Their Mechanical and Barrier Properties Improvement: A Global View

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