A Review on Antioxidant, Anti-Inflammatory and Gastroprotective Abilities of Mango (Magnifera indica) Leaf Extract and Mangiferin

Sj, Stohs; Swaroop, Anand; Moriyama, Hiroyoshi; Bagchi, Manashi; Ahmad, Tauseef; Bagchi, Debasis

doi:10.15744/2393-9060.5.303

Cited by 5 publications

(5 citation statements)

References 47 publications

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“…When converted to dried weights of initial materials, contents of mangiferin were identified within a range from 8.71 to 81.82 mg/g dried powder, which is equal to 0.87 to 8.18%. These results were similar to but slightly lower than those reported by Stohs et al [29], who reported that mangiferin contents in mango leaves varied from 2 to 15% depending on varieties and geographic sources. In our study, the mangiferin content of young dark reddish brown leaves was 81.82 mg/g, in accordance with the report of Parafati et al [30], who also investigated red-colored mango leaves and reported the concentration to be 84.52 mg/g dried weight.…”

Section: Effects Of Maturity Stages On Mangiferin Contents Of Mango L...supporting

confidence: 90%

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Effects of Maturation on Antibacterial Properties of Vietnamese Mango (Mangifera indica) Leaves

Nguyen,

Miyamoto,

Hoang

et al. 2024

Molecules

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This study, for the first time, has investigated the relationships between alterations of mangiferin contents in mango leaves at different maturity stages and their antibacterial properties. Leaves were classified into six different maturity stages based on their color: (1) young dark reddish brown, (2) young yellow, (3) young light green, (4) mature green, (5) old dark green, and (6) old yellow leaves. Ethanol extracts were then examined against Gram-positive and Gram-negative bacteria, applying broth dilution and agar well diffusion methods. In addition, we also measured the mangiferin contents in leaves at different stages for the purpose of evaluating how the changes in this phytochemistry value affects their activities against bacteria. The results showed that extracts from leaves at young ages had better antibacterial properties than those from old leaves, as evidenced by the lower minimum inhibitory concentrations and larger inhibitory zones. In addition, we also found that the contents of mangiferin were significantly decreased followed the maturation process. These results suggest that mango leaves at young stages, especially dark reddish brown and young yellow leaves, are preferable for application in bacterial infections and other therapies related to mangiferin’s constituents.

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Section: Effects Of Maturity Stages On Mangiferin Contents Of Mango L...supporting

confidence: 90%

“…In contrast, this was higher the result of Loan et al [33], who identified the content to be 9.51 mg/g. The differences might be explained via the fact that mangiferin constituents in mango leaves are largely dependent on origin and plant variety [28,29].…”

Section: Effects Of Maturity Stages On Mangiferin Contents Of Mango L...mentioning

confidence: 99%

Effects of Maturation on Antibacterial Properties of Vietnamese Mango (Mangifera indica) Leaves

Nguyen,

Miyamoto,

Hoang

et al. 2024

Molecules

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“…4 Values are expressed as mean ± standard deviation (S.D.) 5 Different superscript letters in the column indicate differences are significant at p < 0.05.…”

Section: Phenolic Yield and Total Phenolic Contentsmentioning

confidence: 99%

“…The bioactive effects reported for M. indica include antioxidant activity, anti-inflammatory, antipyretic, antibacterial, antiviral, antimicrobial, and anticancer, as well as hepatoprotective and gastroprotective properties, in addition to immunomodulatory and lipid-lowering drug effects [2][3][4][5]. Particularly, it has been reported that mango exhibits antiproliferative activity in MDA-MB-231 adenocarcinoma breast cell lines, HepG2 liver, and HL-60 leukemia cancer cells [6], as well as antitumoral effects on MCF-7 breast carcinoma cells [7], Molt-4 leukemia, A-549 lung, LnCap prostate, and SW-480 colon cancer cells [8].…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic Characterization, Antioxidant, and Cytotoxic Activities of Mangifera indica Cultivars from Costa Rica

Navarro

Arnáez

Moreira

et al. 2019

Foods

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The phenolic profile of skin and flesh from Manifera indica main commercial cultivars (Keitt and Tommy Atkins) in Costa Rica was studied using ultra performance liquid chromatography coupled with high resolution mass spectrometry (UPLC-ESI-MS) on enriched phenolic extracts. A total of 71 different compounds were identified, including 32 gallates and gallotannins (of different polymerization degree, from galloyl hexose monomer up to decagalloyl hexoses and undecagalloyl hexoses); seven hydroxybenzophenone (maclurin and iriflophenone) derivatives, six xanthonoids (including isomangiferin and mangiferin derivatives); 11 phenolic acids (hydroxybenzoic and hydroxycinnamic acid derivatives); and eight flavonoids (rhamnetin and quercetin derivatives). The findings for T. Atkins skin constitute the first report of such a high number and diversity of compounds. Also, it is the first time that the presence of gallotannin decamers and undecamers are reported in the skin and flesh of Keitt cultivar and in T. Atkins skins. In addition, total phenolic content (TPC) was measured with high values especially for fruits’ skins, with a TPC of 698.65 and 644.17 mg gallic acid equivalents/g extract, respectively, for Keitt and T. Atkins cultivars. Antioxidant potential using 2,2-diphenyl-1-picrylhidrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) methods were evaluated, with T. Atkins skin showing the best values for both DPPH (IC50 = 9.97 µg/mL) and ORAC (11.02 mmol TE/g extract). A significant negative correlation was found for samples between TPC and DPPH antioxidant values (r = −0.960, p < 0.05), as well as a significant positive correlation between TPC and ORAC (r = 0.910, p < 0.05) and between DPPH and ORAC antioxidant methods (r = 0.989, p < 0.05). Also, cytotoxicity was evaluated in gastric adenocarcinoma (AGS), hepatocarcinoma (HepG2), and colon adenocarcinoma (SW620), with T. Atkins skin showing the best results (IC50 = 138–175 µg/mL). Finally, for AGS and SW 620 cell lines particularly, a high significant negative correlation was found between cytotoxic activity and gallotannins (r = −0.977 and r = −0.940, respectively) while for the HepG2 cell line, the highest significant negative correlation was found with xanthonoids compounds (r = −0.921).

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“…The plant is used extensively in religious and social ceremonies and for nutrition and therapeutic purposes. According to Stohs et al (2018), the leaves are employed in Hinduism on practically all significant occasions, including worship and wedding rituals [ 19 ]. According to Laurindo et al (2015), the fruit’s outer peels are used as cosmetics, and Namngam and Pinsirodom (2017) reported that the seeds are used to make beauty creams.…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy

Sarfraz,

Khan,

Batiha

et al. 2023

Cancers

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Mangiferin (MGF), a xanthone derived from Mangifera indica L., initially employed as a nutraceutical, is now being explored extensively for its anticancer potential. Scientists across the globe have explored this bioactive for managing a variety of cancers using validated in vitro and in vivo models. The in vitro anticancer potential of this biomolecule on well-established breast cancer cell lines such as MDA-MB-23, BEAS-2B cells and MCF-7 is closer to many approved synthetic anticancer agents. However, the solubility and bioavailability of this xanthone are the main challenges, and its oral bioavailability is reported to be less than 2%, and its aqueous solubility is also 0.111 mg/mL. Nano-drug delivery systems have attempted to deliver the drugs at the desired site at a desired rate in desired amounts. Many researchers have explored various nanotechnology-based approaches to provide effective and safe delivery of mangiferin for cancer therapy. Nanoparticles were used as carriers to encapsulate mangiferin, protecting it from degradation and facilitating its delivery to cancer cells. They have attempted to enhance the bioavailability, safety and efficacy of this very bioactive using drug delivery approaches. The present review focuses on the origin and structure elucidation of mangiferin and its derivatives and the benefits of this bioactive. The review also offers insight into the delivery-related challenges of mangiferin and its applications in nanosized forms against cancer. The use of a relatively new deep-learning approach to solve the pharmacokinetic issues of this bioactive has also been discussed. The review also critically analyzes the future hope for mangiferin as a therapeutic agent for cancer management.

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A Review on Antioxidant, Anti-Inflammatory and Gastroprotective Abilities of Mango (Magnifera indica) Leaf Extract and Mangiferin

Cited by 5 publications

References 47 publications

Effects of Maturation on Antibacterial Properties of Vietnamese Mango (Mangifera indica) Leaves

Effects of Maturation on Antibacterial Properties of Vietnamese Mango (Mangifera indica) Leaves

Polyphenolic Characterization, Antioxidant, and Cytotoxic Activities of Mangifera indica Cultivars from Costa Rica

Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy

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