A review on background, process and application of electrospun nanofibers for tissue regeneration

Abstract

Electrospinning is a versatile method which is used to synthesize nano/micro sized fibers under the influence of electric field. Electrospun nanoscaffolds are one of the widely accepted platforms for cultivating soft and hard tissues as they create a prefect micro-environment for cell adhesion, proliferation and differentiation. Nanoscaffolds are widely used in the field of tissue engineering due to their versatility in aiding the growth of different types of cells and tissues for varied applications. The composition, molecular weight and structure of polymer used to fabricate nanoscaffold plays an important role in determining the size and strength of the nanofibers prepared. This review gives information about the background, process and different types of polymers used in electrospinning. Recent advances in culturing liver cells, osteoblasts, skin cells, neural cells and coronary artery smooth muscle cells on nanoscaffolds are also elucidated.

Morphology, Cytotoxicity, and Antimicrobial Activity of Electrospun Polycaprolactone Biomembranes with Gentamicin and Nano-Hydroxyapatite

“…Electrospun fibers are one of the most widely proven platforms for growing soft and hard tissues, because they create a perfect micro-environment for cell adhesion, proliferation, and differentiation. Also, nanoscaffolds are proven to aid in the growth of different types of cells and tissues [ 26 ]. Our results showed that the fiber diameter is affected, as indicated by the GEN/nHAP content, also shown in previous research [ 27 ].…”

Current Innovations in Intraocular Pressure Monitoring Biosensors for Diagnosis and Treatment of Glaucoma—Novel Strategies and Future Perspectives

“…Electrospun nanofibers for the regeneration of soft tissues have gained a lot of interest due to their distinctive composition and structural characteristics. The three-dimensional architecture, composition, morphology, biological functions and specific optical, magnetic and electric properties of electrospun nanofibers can be easily controlled based upon the application [ 63 ]. A type of molecular aggregation called a polymer micelle is caused by non-covalent bond interactions between several polymer chains.…”