The simulation configuration and process analysis of the Subcritical Organic Rankine Cycle (SORC) system are carried out for the potential comparison between pure, binary, and ternary zeotropic mixtures of R1234ze(E), R1234yf, and R134a as refrigerant working fluids based on applying the flue gas as a heat source with medium temperature. The compression pressure was selected as an optimized variable input parameter of SORC with the lower limit of boundary condition (1.4 MPa); to mitigate air ingress and sub-atmospheric pressure that led to approach optimum net power output generated. Increasing the compression pressure has a positive relationship with the superheated temperature and the mass enthalpy change in the evaporation and, therefore, in the expansion process. In parallel, the enthalpy and entropy changes in the flue gas and cold water positively correlate with exergy efficiency. So, R1234ze(E)/ R1234yf/R134a with 68.35% and R1234yf/ R134a with 69.29% as the lowest and highest exergy efficiency in the highest compression pressure; furthermore, the SIC consequences of increasing the cost of each component of the SORC system that has a direct relationship with the PPC and the required exchanger area of evaporation and condensation process and generating a net power output of the turbine. As a result, the maximum to the minimum value of specific investment cost (SIC) achieves R134a with 5807402.18-22455670.61 $.kW-1 and R1234yf with 16.82-17.38% reduction, respectively. To sum up, the lowest payback period (PBP) was R1234yf with 302 days.