A Review on Bone Grafting, Bone Substitutes and Bone Tissue Engineering

Samarawickrama, Kasun G.

doi:10.1145/3239438.3239457

Cited by 6 publications

(4 citation statements)

References 71 publications

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“…There were 178 million bone fractures that occurred globally in 2019 [1]. The clinical gold-standard for bone graft substitutes are allografts and autografts [2][3][4][5], with ~2 million autologous or allogenic/artificial bone grafts used between 1992 and 2007 in the United States [6]. Both suffer from key limitations.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, limited donor tissue and the need to create a secondary injury site for autografts [2][3][4][5]. And concerns about inconsistent purification methods, infection or rejection [2-5, 7, 8], and variability in healing based on both donor and recipient biology exist for allografts [2][3][4][5]. Tissue engineering offers a framework to develop biomaterials for bone regeneration that may address limitations in allograft and autograft approaches.…”

Section: Introductionmentioning

confidence: 99%

“…Both suffer from key limitations. Notably, limited donor tissue and the need to create a secondary injury site for autografts [2][3][4][5]. And concerns about inconsistent purification methods, infection or rejection [2-5, 7, 8], and variability in healing based on both donor and recipient biology exist for allografts [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Donor Variability in Human Mesenchymal Stem Cell Osteogenic Response as a Function of Passage Conditions and Donor Sex

Kolliopoulos,

Tiffany,

Polanek

et al. 2023

Preprint

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Contemporary tissue engineering efforts often seek to use mesenchymal stem cells (MSCs) due to their potential to differentiate to various tissue-specific cells and generate a pro-regenerative secretome. While MSC differentiation and therapeutic potential can differ as a function of matrix environment, it may also be widely influenced as a function of donor-to-donor variability. Further, effects of passage number and donor sex may further convolute the identification of clinically effective MSC-mediated regeneration technologies. We report efforts to adapt a well-defined mineralized collagen scaffold platform to study the influence of MSC proliferation and osteogenic potential as a function of passage number and donor sex. Mineralized collagen scaffolds broadly support MSC osteogenic differentiation and regenerative potency in the absence of traditional osteogenic supplements for a wide range of MSCs (rabbit, rat, porcine, human). We obtained a library of bone marrow and adipose tissue derived stem cells to examine donor-variability of regenerative potency in mineralized collagen scaffolds. MSCs displayed reduced proliferative capacity as a function of passage duration. Further, MSCs showed significant sex-based differences. Notably, MSCs from male donors displayed significantly higher metabolic activity and proliferation while MSCs from female donor displayed significantly higher osteogenic response via increased alkaline phosphate activity, osteoprotegerin release, and mineral formation in vitro. Our study highlights the essentiality of considering MSC donor sex and culture expansion in future studies of biomaterial regenerative potential.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Donor Variability in Human Mesenchymal Stem Cell Osteogenic Response as a Function of Passage Conditions and Donor Sex

Kolliopoulos,

Tiffany,

Polanek

et al. 2023

Preprint

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show abstract

“…As a result, bone grafting has emerged as an effective therapeutic strategy for rebuilding and repairing damaged bone tissues in order to overcome bone-destructive causes. Autografting, allografting, and xenografting are the three bone-grafting processes [ 5 , 6 ]. Autografts obtained from the patient’s own body are considered the gold standard in bone restoration.…”

Section: Introductionmentioning

confidence: 99%

Application of fused deposition modeling (FDM) on bone scaffold manufacturing process: A review

Winarso

Anggoro

Ismail

et al. 2022

Heliyon

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Donor Sex and Passage Conditions Influence MSC Osteogenic Response in Mineralized Collagen Scaffolds

Kolliopoulos,

Tiffany,

Polanek

et al. 2024

Adv Healthcare Materials

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Contemporary tissue engineering efforts often seek to use mesenchymal stem cells (MSCs) due to their multi‐potent potential and ability to generate a pro‐regenerative secretome. While many have reported the influence of matrix environment on MSC osteogenic response, few have investigated the effects of donor and sex. Here, a well‐defined mineralized collagen scaffold is used to study the influence of passage number and donor‐reported sex on MSC proliferation and osteogenic potential. A library of bone marrow and adipose tissue‐derived stem cells from eight donors to examine donor viability in osteogenic capacity in mineralized collagen scaffolds is obtained. MSCs displayed reduced proliferative capacity as a function of passage duration. Further, MSCs showed significant sex‐associated variability in osteogenic capacity. Notably, MSCs from male donors displayed significantly higher cell proliferation while MSCs from female donors displayed significantly higher osteogenic response via increased alkaline phosphate activity, osteoprotegerin release, and mineral formation in vitro. The study highlights the essentiality of including donor‐reported sex as an experimental variable and reporting culture expansion in future studies of biomaterial regenerative potential.

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A Review on Bone Grafting, Bone Substitutes and Bone Tissue Engineering

Cited by 6 publications

References 71 publications

Donor Variability in Human Mesenchymal Stem Cell Osteogenic Response as a Function of Passage Conditions and Donor Sex

Donor Variability in Human Mesenchymal Stem Cell Osteogenic Response as a Function of Passage Conditions and Donor Sex

Application of fused deposition modeling (FDM) on bone scaffold manufacturing process: A review

Donor Sex and Passage Conditions Influence MSC Osteogenic Response in Mineralized Collagen Scaffolds

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