A review on chitosan and its nanocomposites in drug delivery

Ali, Akbar; Ahmed, Shakeel

doi:10.1016/j.ijbiomac.2017.12.078

Cited by 932 publications

(422 citation statements)

References 164 publications

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“…Its morphology is shown in Figure A with an SEM photograph after the washing. The surface of microparticles was found to be smooth, similar to those reported before . The average diameter of the microspheres is 15.14 ± 3.15 μm, and the particle size distribution is shown in Figure B.…”

Section: Resultssupporting

confidence: 83%

“…Although the peaks seen in the composite are not as clear as the XRD of a pure HA, the characteristic peaks of HA are clearly visible at time 12 hours; the broad peak at 20° is almost undetected, while the sharp peak at 32° indicates that the HA is fully crystallized. The broad peak at 20° assigns to CS, and sharp diffraction peaks at 31.8 and 25.9 correspond to HA peaks …”

Section: Resultsmentioning

confidence: 99%

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In situ biomimetic formation of nano‐hydroxyapatite crystals on chitosan microspheres

Huang

Niu

et al. 2019

Polymers for Advanced Techs

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Chitosan (CS) is a biocompatible, noncytotoxic biomaterial used before as base material for composites. On the other hand, nano‐hydroxyapatite (nHA) is one of the main components of human bones, highly used for biomedical applications. In this work, CS microspheres were produced under a W/O emulsion system. CS microspheres with calcium ions were then exposed to Na3PO4 solution. In situ biomimetic nHA crystals were formed on CS microspheres to generate 15.14 ± 3.15‐μm composite microspheres. The microspheres were subsequently seeded with MG63 osteoblasts to observe their cell responses. All microspheres were characterized via scanning electron microscopy (SEM), phase‐contrast photomicroscopy, and X‐ray diffraction (XRD) analysis. The results showed flake‐like shape and islet‐like growth of nHA depositions presented on the surface of the CS microspheres. In vitro tests indicated that the CS/nHA microparticles were not only biocompatible but also enhanced cell adhesion and elongation due to the in situ biomimetic synthesis method.

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Section: Resultssupporting

confidence: 83%

Section: Resultsmentioning

confidence: 99%

In situ biomimetic formation of nano‐hydroxyapatite crystals on chitosan microspheres

Huang

Niu

et al. 2019

Polymers for Advanced Techs

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“…Ali and Ahmed (2018) summarized all different forms of chitosan that have been used for drug delivery. Ali and Ahmed (2018) summarized all different forms of chitosan that have been used for drug delivery.…”

Section: Chitosanmentioning

confidence: 99%

Nanodiamond in composite: Biomedical application

Rehman

Houshyar

Wang

2020

J Biomedical Materials Res

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The biocompatibility of materials is the determining factor for them to be applied in biomedical areas. Nanodiamond (ND) has gained increasing interest in this area due to its biocompatibility, ease of surface functionalization and excellent mechanical performance. ND has been widely used to reinforce biopolymers, and the resultant biocomposites have found applications in bone tissue engineering, chemotherapeutic drug delivery, and wound healing. Fluorescent ND, when combined with biopolymers, is serving for bioimaging and sensing applications. Herein, we contribute a description of ND, recent trends in its adoption for biopolymers, functionalization methods, amalgamation techniques of ND with biopolymers, potential applications of these composites in the biomedical field and future perspectives.biocompatibility, biocomposites, biopolymers, nanodiamond, scaffold

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“…Thanks to the specificity of short sequences recognized by cell receptors, in recent years, many peptides have been used to improve the specific targeting of biologically active substances such as iRNAs, DNA, peptides and organic molecules [24,25]. Actually numerous designed peptide sequences are able to recognize, transport and release in a highly specific manner biologically active natural compounds to specifically kill cancer cells (Fig.…”

Section: Delivery and Targeting In Oncologymentioning

confidence: 99%

Design of new nanocarriers for biomedical applications

Colone¹,

Angiolella²,

Vitali³

et al. 2018

AIP Conference Proceedings

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Abstract.One of the main prerequisite of a therapeutic drug is to overcome a series of physiological barriers and it to be less toxic for the human. To this aim, it is necessary to find a carrying vector able to enhance drug internalization and to improve its therapeutic efficacy. Presently, biocompatible and biodegradable nanoparticles (NPs) as some effective drug delivery devices, are widely studied. In order to increase the antimicrobial and antitumor efficacy of different natural products numerous studies are in progress to evaluate different drug delivery systems (cationic liposomes, lysozymeshelled hollow nano/microbubbles and nano/microcapsules). This delivery system would have a synergistic and additive effect decreasing the drug resistance reactions too. The present article has tried to review some of the latest research on nanocarriers in clinical care.

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A review on chitosan and its nanocomposites in drug delivery

Cited by 932 publications

References 164 publications

In situ biomimetic formation of nano‐hydroxyapatite crystals on chitosan microspheres

In situ biomimetic formation of nano‐hydroxyapatite crystals on chitosan microspheres

Nanodiamond in composite: Biomedical application

Design of new nanocarriers for biomedical applications

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