A review on contemporary nanomaterial-based therapeutics for the treatment of diabetic foot ulcers (DFUs) with special reference to the Indian scenario

Sethuram, Lakshimipriya; John, Thomas; Mukherjee, Amitava; Chandrasekaran, Natarajan

doi:10.1039/d1na00859e

Cited by 18 publications

(18 citation statements)

References 205 publications

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“…Liposomes loaded with the hydrophobic drugs in the double layer of phospholipid and the hydrophilic drug encapsulated within the aqueous core served as a potent antimicrobial drug delivery agent for diabetic foot infections. 26 The use of bioactive glass in osteomyelitis potentiates cellular proliferation and improved angiogenesis by effectively bonding to the living tissue creating a stable interface while being coated with the nanocrystalline hydroxyapatite. The material S53P4 which is similar to bioglass initially releases sodium from the surface causing an alkaline surrounding and later releases calcium, silicon, and phosphorous imparting elevated osmotic pressure and inhibiting the bacterial adhesion and colonization to the surface.…”

Section: Biomaterials Used For Diabetic Pedal Ulcers and Osteomyeliti...mentioning

confidence: 99%

Diabetic Pedal Osteomyelitis and Its Treatment

Venkatesan

Rangasamy

2023

Chonnam Med J

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Diabetes is a fast-growing chronic metabolic disorder that is widely associated with foot ulcers. The major challenge among these ulcers is wound infections, altered inflammatory responses, and a lack of angiogenesis that can complicate limb amputation. The foot, because of its architecture, becomes the part most prone to complications and the infection rate is higher mainly between the toes due to the humid nature. Therefore, the infection rate is significantly higher. Wound healing in diabetes is a dynamic process usually delayed due to poor immune function. Diabetes-related pedal neuropathy and perfusion disturbances can lead to a loss of sensation in the foot. This neuropathy can further be a risk factor for ulcer development due to repetitive mechanical stress that later might get infected by the invasion of microorganisms extending to the bone and causing an infection called pedal osteomyelitis. This review details the pathophysiology, the biomaterials aiding in the infection cure and regeneration of bone along with their limitations, as well as their future prospects.

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Section: Biomaterials Used For Diabetic Pedal Ulcers and Osteomyeliti...mentioning

confidence: 99%

Diabetic Pedal Osteomyelitis and Its Treatment

Venkatesan

Rangasamy

2023

Chonnam Med J

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“…Recent advances in nanotechnology have led to the development of lipid‐based nanoemulsions as promising platforms for delivering drugs and bioactive compounds to target tissues. [ 24–28 ]…”

Section: Introductionmentioning

confidence: 99%

“…Recent advances in nanotechnology have led to the development of lipid-based nanoemulsions as promising platforms for delivering drugs and bioactive compounds to target tissues. [24][25][26][27][28] Achieving accurate delineation of wound regions from medical images is paramount for effective diagnosis and treatment planning. In this approach.…”

Section: Introductionmentioning

confidence: 99%

Accelerating Diabetic Wound Healing by Modulating the Inflammatory Environment Using Quercetin–Rosemary Oil Lipid Nanoemulsions with Artificial Intelligence‐Based Wound Closure Analysis

Ali,

Pebam,

Buddhiraju

et al. 2024

Advanced Therapeutics

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Diabetic wounds are a significant complication of diabetes that is characterized by delayed wound healing and a high risk of amputation. Pro‐inflammatory macrophages (M1) and Matrix Metallo protease‐9 (MMP‐9) overexpression play pivotal roles in the extended inflammatory phase observed in diabetic wounds. This study developed a multifunctional lipid nanoemulsion containing quercetin and rosemary oil (Q‐RLNE) that can efficiently convert M1 macrophages to M2, inhibit MMP‐9, and prevent microbial infection, accelerating diabetic wound healing. In‐vitro studies demonstrated that Q‐RLNEs showed excellent biocompatibility and cellular uptake. Additionally, Q‐RLNEs demonstrated effective ROS scavenging, macrophage polarization, MMP‐9 inhibition, and excellent anti‐microbial properties against Staphylococcus aureus (S. aureus). In‐vivo results demonstrated that Q‐RLNE can accelerate and achieve complete wound healing in diabetic‐induced rats by reducing inflammation and promoting angiogenesis with proper collagen deposition and dermal projection regeneration. This study also highlighted the application of the Segment Anything Model (SAM) for precise wound region segmentation. SAM combines attention‐fusion and hybrid fusion strategies for accurate segmentation, enabling comprehensive analysis of wound attributes over time and guiding treatment decisions. The SAM analysis results also align with Q‐RLNE in‐vitro and in‐vivo. The findings of this study suggest that Q‐RLNE is a promising new therapeutic agent for accelerating diabetic wound healing.This article is protected by copyright. All rights reserved

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“…However, current wound dressings usually have serious issues, such as poor moisture management, inadequate wound bed preparation, limited antimicrobial properties, and inadequate healing stimulating capabilities, highlighting the need for more advanced and effective wound dressings that can address these urgent concerns of DFU in the patient community. [7,8,[10][11][12] Promisingly, hydrogel dressings have garnered increasing interest in the management of DFUs due to their excellent moisture-retaining properties and biocompatibility. [13][14][15] Hydrogel dressings are composed of threedimensional networks of water-absorbing polymers that can hold a large amount of water and maintain a moist wound environment.…”

Section: Introductionmentioning

confidence: 99%

“…In general, the selection of wound dressings for diabetic foot ulcers depends on the severity of the ulcer and the stage of the healing process. However, current wound dressings usually have serious issues, such as poor moisture management, inadequate wound bed preparation, limited antimicrobial properties, and inadequate healing stimulating capabilities, highlighting the need for more advanced and effective wound dressings that can address these urgent concerns of DFU in the patient community [7,8,10–12] …”

Section: Introductionmentioning

confidence: 99%

Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

Ko¹,

Liao

2023

BMEMat

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Diabetic foot ulcers (DFU) are a common and often debilitating complication of diabetes that can result in lower limb amputations if left untreated. Hydrogel dressings are three‐dimensional networks of hydrophilic polymers that can absorb and retain large amounts of water, and have been shown to possess excellent biocompatibility, low toxicity, and excellent fluid handling properties. In addition, hydrogels create a moist wound environment that promotes wound healing by supporting cell proliferation, migration, and angiogenesis. Hydrogels, therefore, have emerged as promising wound dressings for promoting DFU healing. In this review, we attempt to chart the landscape of the emerging field of hydrogel as wound dressing for DFU treatment. We will explicitly review the assorted preparation methods for DFU hydrogels as well as a detailed discussion of various types of hydrogels deployed for DFU study. We also crystallize key findings, identify remaining challenges, and present an outlook on the future development of this enticing field.

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A review on contemporary nanomaterial-based therapeutics for the treatment of diabetic foot ulcers (DFUs) with special reference to the Indian scenario

Abstract: Diabetes mellitus (DM) is a predominant chronic metabolic syndrome resulting in various complications and high mortality associated with Diabetic foot ulcer (DFU). Approximately 15-30 % of the diabetic patients suffer...

Cited by 18 publications

References 205 publications

Diabetic Pedal Osteomyelitis and Its Treatment

Diabetic Pedal Osteomyelitis and Its Treatment

Accelerating Diabetic Wound Healing by Modulating the Inflammatory Environment Using Quercetin–Rosemary Oil Lipid Nanoemulsions with Artificial Intelligence‐Based Wound Closure Analysis

Hydrogel wound dressings for diabetic foot ulcer treatment: Status‐quo, challenges, and future perspectives

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