A review on critical appraisal and pathogenesis of polycystic ovarian syndrome

Hajam, Younis Ahmad; Rather, Hilal Ahmad; Neelam,; Kumar, Rajesh; Basheer, Muddasir; Reshi, Mohd Salim

doi:10.1016/j.endmts.2024.100162

Cited by 9 publications

(4 citation statements)

References 209 publications

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“…However, usually women with PCOS suffer from anovulation, infertility, and symptoms of hyperandrogenism such as acne, hirsutism, or female androgenetic alopecia [1][2]. The precise etiology and pathophysiology of PCOS are still not clear because of the multifactorial and complex nature of the disease [4] . Nevertheless, oxidative stress and reduced levels of antioxidants play a significant role in the development of PCOS [8] .…”

Section: Discussionmentioning

confidence: 99%

“…The specific etiology and pathophysiology of PCOS are still unknown due to its heterogeneous and complex nature; however, it includes the interplay between hormones, genes, and environmental factors [4] [5] . It is assumed that some women possess a genetic predisposition, and certain environmental factors, commonly insulin resistance, trigger the development of PCOS [6] .…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, hormonal imbalance leads to the development of cysts in the antral follicles of the ovary, stops ovulation, and disturbs the menstrual cycle, leading to amenorrhea [4] .…”

Section: Introductionmentioning

confidence: 99%

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Effects of antioxidant supplementation for polycystic ovary syndrome

Łopacińska,

Stańczyk,

Korn

et al. 2024

J Educ Health Sport

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Introduction and purpose: Polycystic ovary syndrome is the most common endocrinopathy in women, with a prevalence ranging from 10% to 13%. Oxidative stress and decreased antioxidant levels contribute to the development of various diseases, and one of them is polycystic ovary syndrome. The aim of this review is to provide an overview of the current knowledge about the effects of antioxidant administration in PCOS treatment. A brief description of the state of knowledge: Oxidative stress is an imbalance between increased levels of reactive oxygen species and a decreased efficiency of antioxidant mechanisms, which can potentially cause damage. The harmful effects of free radicals might be neutralized by antioxidants obtained from the diet, such as polyphenols, vitamins C, and E. These compounds improve several aspects of the PCOS pathomechanism, including hormonal imbalance, glucose metabolism, lipid profile, and ovarian functionality. Conclusions: The outcomes of all the reviewed studies in this paper indicate that antioxidants such as resveratrol, curcumin, vitamin C and E, N-acetylcysteine, and melatonin have therapeutic potential in the management of PCOS. However, currently antioxidant therapies cannot be recommended in PCOS therapy since there is a need for more prospective randomized clinical trials on a larger sample to establish a long-term effects of antioxidants supplementation in PCOS, the optimal dosage, and finally to assess which antioxidant is the most efficient in PCOS treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of antioxidant supplementation for polycystic ovary syndrome

Łopacińska,

Stańczyk,

Korn

et al. 2024

J Educ Health Sport

View full text Add to dashboard Cite

show abstract

“…Polycystic ovary syndrome is a systemic metabolic and endocrine disorder that results from the disturbance of adaptive interdependent homeostatic survival networks (metabolic, immune, and neuroendocrine) [ 1 , 2 , 3 , 4 ]. Although a wide variety of theories have been proposed to explain the pathogenesis of PCOS [ 5 , 6 , 7 , 8 , 9 , 10 ], recent evolutionary models have provided a unified framework [ 1 , 2 ]. Evolutionary models characterize PCOS as an evolutionary mismatch disorder that arises from an interaction between genetic and environmental factors [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Parker,

O’Brien,

Yeoh

et al. 2024

JCM

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Polycystic ovary syndrome (PCOS) is a multisystem disorder that presents with a variety of phenotypes involving metabolic, endocrine, reproductive, and psychological symptoms and signs. Women with PCOS are at increased risk of pregnancy complications including implantation failure, miscarriage, gestational diabetes, fetal growth restriction, preterm labor, and pre-eclampsia (PE). This may be attributed to the presence of specific susceptibility features associated with PCOS before and during pregnancy, such as chronic systemic inflammation, insulin resistance (IR), and hyperandrogenism, all of which have been associated with an increased risk of pregnancy complications. Many of the features of PCOS are reversible following lifestyle interventions such as diet and exercise, and pregnant women following a healthy lifestyle have been found to have a lower risk of complications, including PE. This narrative synthesis summarizes the evidence investigating the risk of PE and the role of nutritional factors in women with PCOS. The findings suggest that the beneficial aspects of lifestyle management of PCOS, as recommended in the evidence-based international guidelines, extend to improved pregnancy outcomes. Identifying high-risk women with PCOS will allow targeted interventions, early-pregnancy screening, and increased surveillance for PE. Women with PCOS should be included in risk assessment algorithms for PE.

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Effects of kefir consumption on gut microbiota and health outcomes in women with polycystic ovary syndrome

Çıtar Dazıroğlu,

Acar Tek,

Cevher Akdulum

et al. 2024

Food Science & Nutrition

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Polycystic Ovary Syndrome (PCOS), which is common among women of reproductive age, is characterized by low‐grade chronic inflammation and is associated with several health problems and dysbiosis. Kefir has been shown to have many beneficial health effects; however, its effect on PCOS is unknown. This study aimed to examine the effect of kefir on the intestinal microbiota and health outcomes in PCOS. In this intervention study, 17 women with PCOS consumed 250 mL/day of kefir (containing Lactobacillus kefiranofaciens subsp. kefiranofaciens, Lactobacillus kefiranofaciens subsp. kefirgranum, Lactobacillus kefiri, Lactobacillus acidophilus, Lactobacillus parakefiri, Lactobacillus bulgaricus, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus fermentum, Lactobacillus helveticus, Lactococcus lactis, Leuconostoc mesentereoides, Bifidobacterium bifidum, Streptococcus thermophilus, Kluyveromyces marxianus, Kluyveromyces lactis, Acetobacter pasteurianus, and Saccharomyces cerevisiae) for 8 weeks. Food consumption and physical activity records, anthropometrical measurements, quality of life, and fecal and blood samples were taken at the study's beginning and end. Quality of life in mental health (58.8 ± 15.08; 64.0 ± 15.23, respectively) and physical function (95.00 and 100.00, respectively) categories showed a significant increase after kefir intervention (p < .05). Additionally, Interleukin‐6 (IL‐6), one of the inflammatory cytokines, significantly decreased (174.00 and 109.10 ng/L, respectively) (p < .05). The intestinal barrier permeability was evaluated with zonulin, and no significant change was observed. Gut microbiota analysis showed that while the relative abundance of the class Bacilli and genus Lactococcus significantly increased, the genus Holdemania decreased with kefir consumption (p < .05). In conclusion, kefir appears to be beneficial for improving the microbiota and some health outcomes, like reducing inflammation and improving quality of life in PCOS. Therefore, kefir may be useful in the treatment of PCOS.

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A review on critical appraisal and pathogenesis of polycystic ovarian syndrome

Cited by 9 publications

References 209 publications

Effects of antioxidant supplementation for polycystic ovary syndrome

Effects of antioxidant supplementation for polycystic ovary syndrome

Reducing the Risk of Pre-Eclampsia in Women with Polycystic Ovary Syndrome Using a Combination of Pregnancy Screening, Lifestyle, and Medical Management Strategies

Effects of kefir consumption on gut microbiota and health outcomes in women with polycystic ovary syndrome

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