A review on curcumin colon-targeted oral drug delivery systems for the treatment of inflammatory bowel disease

Enhancing Transdermal Delivery of Curcumin-Based Ionic Liquid Liposomes for Application in Psoriasis

“…Keratinocytes have a high ability for proliferation and differentiation, and can maintain the stability of the skin barrier. The main characteristics of psoriasis are excessive proliferation and abnormal differentiation of keratinocytes. , To confirm the ability of HaCaT cells cultured with Cur-Bet-IL-Lip after 24 h to induce apoptosis and inhibit cell proliferation, we evaluated the survival status. Cur-Bet-IL-Lip significantly inhibited cell proliferation (Figure a).…”

“…In the occurrence and development of inflammation in skin psoriasis, IL-17A, IL-17F, IL-22, IL-1β, and TNF-α are related to the excessive proliferation of keratinocytes and are important cytokines. IL-17 and IL-22 can cause excessive proliferation and differentiation of keratinocytes, leading to skin damage; TNF-α can affect the normal life cycle of keratinocytes and induce inflammatory reactions; , IL-1β can promote IL-17 secretion and amplify the inflammatory response in psoriasis . Therefore, the expression levels of IL-17A, IL-22, and TNF-α in cells were determined using ELISA analysis.…”

Orally-administered nanomedicine systems targeting colon inflammation for the treatment of inflammatory bowel disease: latest advances

“…In recent years, there has been a growing body of literature indicating that oral nanomedicine systems are being developed to specifically target IBD based on its pathological and physiological characteristics. 32,33 However, traditional colon-targeting systems used in IBD treatment, which rely on drug release triggered by factors such as pH, time, pressure, and microbiota, have been linked to inconsistent therapeutic efficacy among patients, largely due to variations in IBD pathophysiological changes and inter-individual variability in the gastrointestinal tract. 29 Therefore, it is crucial to consider the pathophysiological characteristics of the inflammatory site to design drug delivery systems that can effectively target IBD inflammation (Fig.…”

“…In recent years, nanomedicine has rapidly evolved as a field with great potential for the treatment of IBD. 14,33 Oral delivery has gained significant attention due to its convenience and ease of administration. By targeting the colon, nanocarriers for oral delivery have demonstrated the ability to effectively address the known pathophysiological changes present in inflamed gastrointestinal tracts.…”

“…Mechanisms and strategies of oral nano-delivery systems for targeting IBDIn recent years, nanomedicine has rapidly evolved as a field with great potential for the treatment of IBD 14,33. Oral delivery…”