Skin disease is the major health problem around the world. The diagnosis of skin disease remains a challenge to dermatologist profession particularly in the detection, evaluation, and management. Health data are very large and complex due to this processing of data using traditional data processing techniques is very difficult. In this paper, to ease the complexity while processing the inputs, we use multilayered perceptron with backpropagation neural networks (MLP-BPNN). The image is collected from the devices that contain nanotechnology sensors, which is the state-of-art in the proposed model. The nanotechnology sensors sense the skin for its chemical, physical, and biological conditions with better detection specificity, sensitivity, and multiplexing ability to acquire the image for optimal classification. The MLP-BPNN technique is used to envisage the future result of disease type effectively. By using the above MLP-BPNN technique, it is easy to predict the skin diseases such as melanoma, nevus, psoriasis, and seborrheic keratosis.