A review on diverse heterocyclic compounds as the privileged scaffolds in non-steroidal aromatase inhibitors

Naringin prevents follicular atresia by inhibiting oxidative stress in the aging chicken

“…Estrogen, playing a key role in defending against oxidative stress and stimulating cell proliferation and promoting follicle growth and inhibiting atresia, is a steroid hormone present in the blood and ovaries of poultry and derived from the follicular inner membrane cells of the ovary, mainly estradiol, which can be converted from androgens catalyzed by aromatase ( Quirk et al., 2004 ; La Colla et al., 2017 ; Rani et al., 2021 ). Whether in mammals or poultry, female aging is accompanied by a decline in E 2 levels.…”

Targeting Breast Cancer: An Overlook on Current Strategies

“…Type I inhibitors, known as aromatase inactivators, have a steroidal structure similar to androgens and inactivate the enzyme irreversibly by blocking the substrate-binding site; whereas type II inhibitors are nonsteroidal and their action is reversible [ 95 ]. Most of the type II inhibitors are heterocyclic compounds—such as azoles, chromene, coumarin, xanthone, triphenylethylene, indole, sulfonamide, pyrimidines, pyridine, quinolone, and thiourea [ 96 ]. The treatment with AIs in early BC patients determined improvements of clinical psychological features, and health related quality of life was observed in BC survivors [ 97 ].…”

Synthesis of 2-aminopropyl benzopyran derivatives as potential agents against triple-negative breast cancer

“…18,19 Therefore, the synthesis of the benzopyran nucleus has been performed by numerous medicinal chemistry groups in their search for new anti-tumor agents. 20,21 Our research group previously isolated polycerasoidol and polyalthidin (Fig. 1) from the stem bark of Polyalthia cerasoides (Annonaceae).…”

“…18,19 Therefore, the synthesis of the benzopyran nucleus has been performed by numerous medicinal chemistry groups in their search for new anti-tumor agents. 20,21…”