A review on electrospun polymeric nanofibers: Production parameters and potential applications

Ibrahim, Hassan M.; Klingner, Anke

doi:10.1016/j.polymertesting.2020.106647

Cited by 251 publications

(141 citation statements)

References 292 publications

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“…In Figure 1a, the jet appears to break, at a given point, in a multitude of different jets, but it is just an illusion produced by the glints of the bending coils of the single jet, as excellently demonstrated in literature [6], as well as several electro-hydrodynamic models and theories predicting the path of an electrically driven jet in electrospinning [7][8][9]. In brief, an electrically-driven jets pushed from its source by repulsive forces undergoes to an axisymmetric motion accompanied by an axisymmetric stretching that reduce the jet radius and increase the length of the jet portion [4]. As the distance of electrical charges brought by the jet increases, the jet path becomes unstable by non-axisymmetric forces, so that a lateral motion of the jet is produced resulting in spiraling loops [9].…”

Section: Electrospinning Basic Principlesmentioning

confidence: 92%

“…Process parameters influences the characteristics of the resulting nanofibers (e.g., fiber size and morphology, layer density, and thickness) [1]. Investigations on the effect of process parameters on electrospun fiber size and morphology have been reported in several reviews [2][3][4]. Factors that influence the diameter of the fibers are: polymer(s) concentration in the solution, feeding rate of the solution, nature of the solvent used, electrical conductivity of the solution, and applied voltage.…”

Section: Electrospinning Basic Principlesmentioning

confidence: 99%

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Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

et al. 2020

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Electrospinning is gaining increasing interest in the biomedical field as an eco-friendly and economic technique for production of random and oriented polymeric fibers. The aim of this review was to give an overview of electrospinning potentialities in the production of fibers for biomedical applications with a focus on the possibility to combine biomechanical and topographical stimuli. In fact, selection of the polymer and the eventual surface modification of the fibers allow selection of the proper chemical/biological signal to be administered to the cells. Moreover, a proper design of fiber orientation, dimension, and topography can give the opportunity to drive cell growth also from a spatial standpoint. At this purpose, the review contains a first introduction on potentialities of electrospinning for the obtainment of random and oriented fibers both with synthetic and natural polymers. The biological phenomena which can be guided and promoted by fibers composition and topography are in depth investigated and discussed in the second section of the paper. Finally, the recent strategies developed in the scientific community for the realization of electrospun fibers and for their surface modification for biomedical application are presented and discussed in the last section.

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Section: Electrospinning Basic Principlesmentioning

confidence: 92%

Section: Electrospinning Basic Principlesmentioning

confidence: 99%

Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

et al. 2020

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“…Such porous nanofibrous scaffolds with a higher surface to volume ratio are also similar to crosslinked porous collagen fibers (50–500 nm) found in the native ECM [ 9 , 10 , 11 ]. Hence, substantial effort has been devoted to producing nanoscale fibers to imitate the architectural structure of the native ECM [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering

et al. 2020

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Many types of polymer nanofibers have been introduced as artificial extracellular matrices. Their controllable properties, such as wettability, surface charge, transparency, elasticity, porosity and surface to volume proportion, have attracted much attention. Moreover, functionalizing polymers with other bioactive components could enable the engineering of microenvironments to host cells for regenerative medical applications. In the current brief review, we focus on the most recently cited electrospun nanofibrous polymeric scaffolds and divide them into five main categories: natural polymer-natural polymer composite, natural polymer-synthetic polymer composite, synthetic polymer-synthetic polymer composite, crosslinked polymers and reinforced polymers with inorganic materials. Then, we focus on their physiochemical, biological and mechanical features and discussed the capability and efficiency of the nanofibrous scaffolds to function as the extracellular matrix to support cellular function.

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“…The novelty of this research includes the production of nanofibers from low-molecular weight collagen and keratin hydrolysates with a high content of proteins (13.6% w/v, 25% w/v, and 22% w/v for collagen hydrolysate, rabbit collagen glue, and keratin hydrolysate, respectively) by electrospinning. The objectives of this study were (1) to extract and characterize the collagen hydrolysate (HC10), collagen glue (RCG), and keratin hydrolysate (KH) from bovine tanned leather by-products, pickled rabbit skin, and sheepskin wool, respectively; (2) to characterize the protein-based nanofibers obtained by electrospinning for potential biomedical field application; and (3) to demonstrate that the structure of protein-based nanofibers still preserves the secondary collagen structure without being totally affected by the extraction and electrospinning processing conditions. The nanofibers' surface and mechanical properties have been confirmed using scanning electron microscopy coupled with the energy-dispersive spectroscopy (SEM-EDS) technique, attenuated total reflectance Fourier transform infrared spectroscopy (ATR FT-IR), differential scanning calorimetry (DSC), and indentation tests (Nanoindenter XP).…”

Section: Introductionmentioning

confidence: 99%

“…The research on the biocompatible natural polymers processing by electrospinning for biomedical applications has increased in recent years [ 1 , 2 ]. Nanofibers with different thermoplastic polymers, biomaterials, or active compounds (dyes, drugs, light-sensitive or conductive organics, and piezoelectric materials) [ 3 ] can be obtained by electrospinning.…”

Section: Introductionmentioning

confidence: 99%

New Nanofibers Based on Protein By-Products with Bioactive Potential for Tissue Engineering

et al. 2020

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Concentrated collagen hydrolysate (HC10CC), rabbit collagen glue (RCG), and keratin hydrolysate (KH) were investigated in terms of their extraction from mammalian by-products and processing by electrospinning. The electrospun nanofibers were characterized by scanning electron microscopy coupled with the energy dispersive X-ray spectroscopy (SEM/EDS), attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC), and indentation tests. The cytotoxicity of the electrospun nanofibers was conducted on L929 fibroblast cells using MTT and LDH assays and cell morphology observations. The electrospun RCG and KH nanofibers morphology showed an average size of nanofibers ranging between 44 and 410 nm, while the electrospun HC10CC nanofibers exhibited higher sizes. The ATR-FTIR spectra performed both on extracted proteins and electrospun nanofibers showed that the triple helix structure of collagen is partially preserved. The results were in agreement with the circular dichroism analysis for protein extracts. Furthermore, the viscoelastic properties of electrospun KH nanofibers were superior to those of electrospun RCG nanofibers. Based on both in vitro quantitative and qualitative analysis, the electrospun nanofibers were not cytotoxic, inducing a healthy cellular response. The results of new electrospun protein-based nanofibers may be useful for further research on bioactive properties of these nanofibers for tissue engineering.

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A review on electrospun polymeric nanofibers: Production parameters and potential applications

Cited by 251 publications

References 292 publications

Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Topographical and Biomechanical Guidance of Electrospun Fibers for Biomedical Applications

Electrospun Nanofibers of Natural and Synthetic Polymers as Artificial Extracellular Matrix for Tissue Engineering

New Nanofibers Based on Protein By-Products with Bioactive Potential for Tissue Engineering

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