A review on emulsification via microfluidic processes

Liu, Yichen; Li, Yongli; Hensel, Andreas; Brandner, Juergen J.; Zhang, Kai; Du, Xiaoze; Yang, Yongping

doi:10.1007/s11705-019-1894-0

Cited by 29 publications

(12 citation statements)

References 119 publications

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“…Emulsification is another process where microfluidic devices have been increasingly used. Due to their versatility and the possibility to control flow in a very precise way, it is possible to use microfluidic devices to produce monodisperse emulsions as well as more complex emulsions such as multiple emulsions [109,110] what can still not be achieved with membrane emulsification. As in the application of microfluidic devices for separation of particles and cells, the yield of microfluidic emulsification is generally low.…”

Section: Discussionmentioning

confidence: 99%

Microfluidics Used as a Tool to Understand and Optimize Membrane Filtration Processes

Schroën

2020

Membranes

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Membrane filtration processes are best known for their application in the water, oil, and gas sectors, but also in food production they play an eminent role. Filtration processes are known to suffer from a decrease in efficiency in time due to e.g., particle deposition, also known as fouling and pore blocking. Although these processes are not very well understood at a small scale, smart engineering approaches have been used to keep membrane processes running. Microfluidic devices have been increasingly applied to study membrane filtration processes and accommodate observation and understanding of the filtration process at different scales, from nanometer to millimeter and more. In combination with microscopes and high-speed imaging, microfluidic devices allow real time observation of filtration processes. In this review we will give a general introduction on microfluidic devices used to study membrane filtration behavior, followed by a discussion of how microfluidic devices can be used to understand current challenges. We will then discuss how increased knowledge on fundamental aspects of membrane filtration can help optimize existing processes, before wrapping up with an outlook on future prospects on the use of microfluidics within the field of membrane separation.

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Section: Discussionmentioning

confidence: 99%

Microfluidics Used as a Tool to Understand and Optimize Membrane Filtration Processes

Schroën

2020

Membranes

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“…In terms of advantages, microfluidics offers size and process control, small particle size, and monodispersity [ 23 ]. Comprehensive discussions about microfluidic technology are accessible in the relevant literature [ 105 , 106 , 107 , 108 ], including the review by Liu et al [ 109 ] that discusses emulsification via microfluidic processes and the appraisal by Jo & Lee [ 103 ] about biopolymer microparticles fabricated by microfluidics for biomedical applications.…”

Section: Overview Of Spherical Particles Fabricationmentioning

confidence: 99%

Spherical Cellulose Micro and Nanoparticles: A Review of Recent Developments and Applications

et al. 2021

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Cellulose, the most abundant natural polymer, is a versatile polysaccharide that is being exploited to manufacture innovative blends, composites, and hybrid materials in the form of membranes, films, coatings, hydrogels, and foams, as well as particles at the micro and nano scales. The application fields of cellulose micro and nanoparticles run the gamut from medicine, biology, and environment to electronics and energy. In fact, the number of studies dealing with sphere-shaped micro and nanoparticles based exclusively on cellulose (or its derivatives) or cellulose in combination with other molecules and macromolecules has been steadily increasing in the last five years. Hence, there is a clear need for an up-to-date narrative that gathers the latest advances on this research topic. So, the aim of this review is to portray some of the most recent and relevant developments on the use of cellulose to produce spherical micro- and nano-sized particles. An attempt was made to illustrate the present state of affairs in terms of the go-to strategies (e.g., emulsification processes, nanoprecipitation, microfluidics, and other assembly approaches) for the generation of sphere-shaped particles of cellulose and derivatives thereof. A concise description of the application fields of these cellulose-based spherical micro and nanoparticles is also presented.

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“…However, particle size will also be influenced by a range of other factors, including drug loading, polymer chemistry, polymer concentration, additives, and other formulation conditions [ 6 , 28 ]. The innovation or optimization of microfluidic systems will be facilitated with the development of advanced manufacturing techniques [ 29 , 30 , 31 ]. Hence, it is important to systematically investigate the chemical and physical parameters that influence particle size using the microfluidic method.…”

Section: Introductionmentioning

confidence: 99%

Optimisation of a Microfluidic Method for the Delivery of a Small Peptide

Han

Kumar

et al. 2021

Pharmaceutics

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Peptides hold promise as therapeutics, as they have high bioactivity and specificity, good aqueous solubility, and low toxicity. However, they typically suffer from short circulation half-lives in the body. To address this issue, here, we have developed a method for encapsulation of an innate-immune targeted hexapeptide into nanoparticles using safe non-toxic FDA-approved materials. Peptide-loaded nanoparticles were formulated using a two-stage microfluidic chip. Microfluidic-related factors (i.e., flow rate, organic solvent, theoretical drug loading, PLGA type, and concentration) that may potentially influence the nanoparticle properties were systematically investigated using dynamic light scattering and transmission electron microscopy. The pharmacokinetic (PK) profile and biodistribution of the optimised nanoparticles were assessed in mice. Peptide-loaded lipid shell-PLGA core nanoparticles with designated size (~400 nm) and a sustained in vitro release profile were further characterized in vivo. In the form of nanoparticles, the elimination half-life of the encapsulated peptide was extended significantly compared with the peptide alone and resulted in a much higher distribution into the lung. These novel nanoparticles with lipid shells have considerable potential for increasing the circulation half-life and improving the biodistribution of therapeutic peptides to improve their clinical utility, including peptides aimed at treating lung-related diseases.

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A review on emulsification via microfluidic processes

Cited by 29 publications

References 119 publications

Microfluidics Used as a Tool to Understand and Optimize Membrane Filtration Processes

Microfluidics Used as a Tool to Understand and Optimize Membrane Filtration Processes

Spherical Cellulose Micro and Nanoparticles: A Review of Recent Developments and Applications

Optimisation of a Microfluidic Method for the Delivery of a Small Peptide

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