A Review on Ethnopharmacological approaches to Wound Healing and Curative Progression

Netam, Ashish Kumar; Prasad, Jhakeshwar; Satapathy, Trilochan

doi:10.5958/2321-5836.2019.00008.9

Cited by 5 publications

(6 citation statements)

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“…A total of 24 articles were excluded as they were duplicated. Exclusion criteria were [ 1 ] nonhuman samples and [ 2 ] protocol-based articles with no reported results. A total of 61 articles were excluded, leaving 17 articles for review ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…Disruption in the integrity of skin, mucosal surfaces, or limb tissue can lead to wound formation. Wounds can occur as part of a disease process, either accidentally or intentionally [ 1 ]. In the healing process, several cellular and extracellular pathways are activated in a fully regulated and coordinated manner, with the aim of restoring tissue integrity.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory and Restorative Effects of Olives in Topical Application

Taheri

Amiri‐Farahani

2021

Dermatology Research and Practice

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Background and Objective. Olive oil is used as a traditional treatment for wounds, sores, and infections, and the effectiveness of topical use and absence of side effects have been reported in various clinical trials. The present study is an overview of the anti-inflammatory properties of olive oil in its topical application for various skin diseases and wounds. Methods. A literature search was conducted (1990–2021) in Medline, Embase, CINAHL, Google Scholar, Science Direct, SID, IranDoc, and Magiran databases. From the 102 reviewed articles, 17 articles were selected to be included in the current article. Results. Various forms of olive have long been used to accelerate the healing of various wounds and skin damage such as diabetic foot ulcers, atopic dermatitis, diaper dermatitis, episiotomy wound, and nipple ulcer but there are still no credible documents or articles that provide reliable evidence of topical use. Conclusion. According to the information obtained from the articles reviewed, olive oil appears to be an effective, safe, and available treatment. This study suggests that olive oil is an alternative remedy to minimize the frequent use of chemical-based treatments. More research may be beneficial to reach certainty in terms of curative properties of olive oil in similar or different injuries in different populations.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Restorative Effects of Olives in Topical Application

Taheri

Amiri‐Farahani

2021

Dermatology Research and Practice

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“…Epithelial cells gain kinesis through epithelial-mesenchymal transition (EMT), allowing for motion in wound closure [ 33 ]. Cytokines are also present in varying concentrations during re-epithelialisation, aiding in epithelial cell morphology alteration, changing from cells with motility to a proliferative stage for repopulation at the wound site, thus completing the wound healing process [ 34 ]. This process is direct for primary intention wound closure.…”

Section: Physiology Of Wound Healingmentioning

confidence: 99%

Applications of drug delivery systems, organic, and inorganic nanomaterials in wound healing

Lo,

Mahmoudi,

Fauzi

2023

Discover Nano

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The skin is known to be the largest organ in the human body, while also being exposed to environmental elements. This indicates that skin is highly susceptible to physical infliction, as well as damage resulting from medical conditions such as obesity and diabetes. The wound management costs in hospitals and clinics are expected to rise globally over the coming years, which provides pressure for more wound healing aids readily available in the market. Recently, nanomaterials have been gaining traction for their potential applications in various fields, including wound healing. Here, we discuss various inorganic nanoparticles such as silver, titanium dioxide, copper oxide, cerium oxide, MXenes, PLGA, PEG, and silica nanoparticles with their respective roles in improving wound healing progression. In addition, organic nanomaterials for wound healing such as collagen, chitosan, curcumin, dendrimers, graphene and its derivative graphene oxide were also further discussed. Various forms of nanoparticle drug delivery systems like nanohydrogels, nanoliposomes, nanofilms, and nanoemulsions were discussed in their function to deliver therapeutic agents to wound sites in a controlled manner.

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“…It is a natural, biological, and sophisticated process that occurs after an injury in tissue, which involves blood cells, connective tissue, parenchymal cells, ECM, and soluble mediators such as cytokines and growth factors interacting with each other during the wound healing mechanism. Classically, there are four major phases in wound healing; hemostasis, inflammation, tissue proliferation, and tissue maturation or remodeling [ 23 , 24 ]. The underlying connective tissue is exposed upon injury to the skin, and the collagens attract platelets to the injury site.…”

Section: Skin Wound Healingmentioning

confidence: 99%

The Insights of Microbes’ Roles in Wound Healing: A Comprehensive Review

2021

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A diverse range of normal flora populates the human skin and numbers are relatively different between individuals and parts of the skin. Humans and normal flora have formed a symbiotic relationship over a period of time. With numerous disease processes, the interaction between the host and normal flora can be interrupted. Unlike normal wound healing, which is complex and crucial to sustaining the skin’s physical barrier, chronic wounds, especially in diabetes, are wounds that fail to heal in a timely manner. The conditions become favorable for microbes to colonize and establish infections within the skin. These include secretions of various kinds of molecules, substances or even trigger the immune system to attack other cells required for wound healing. Additionally, the healing process can be slowed down by prolonging the inflammatory phase and delaying the wound repair process, which causes further destruction to the tissue. Antibiotics and wound dressings become the targeted therapy to treat chronic wounds. Though healing rates are improved, prolonged usage of these treatments could become ineffective or microbes may become resistant to the treatments. Considering all these factors, more studies are needed to comprehensively elucidate the role of human skin normal flora at the cellular and molecular level in a chronic injury. This article will review wound healing physiology and discuss the role of normal flora in the skin and chronic wounds.

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A Review on Ethnopharmacological approaches to Wound Healing and Curative Progression

Cited by 5 publications

References 0 publications

Anti-Inflammatory and Restorative Effects of Olives in Topical Application

Anti-Inflammatory and Restorative Effects of Olives in Topical Application

Applications of drug delivery systems, organic, and inorganic nanomaterials in wound healing

The Insights of Microbes’ Roles in Wound Healing: A Comprehensive Review

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