In the past few decades, nanomaterials have gained considerable interest due to their quantum size effects, which display unique magnetic, optical, electrical, and catalytic properties [1][2][3][4]. NPs find extensive biological and non-biological applications due to their unique physical and chemical properties, distinct morphology, size, shape, crystalline nature, surface area-to-volume ratio, electrooptical, magneto-optical, chemical, and mechanical properties [5][6]. Unique chemical and physical properties are exhibited by engineered transition metal oxide NPs compared to their bulk counterparts and are employed in various chemical, physical, biomedical, biological, and pharmaceutical applications. Recently, the attention of many has been focused on the integration of nanotechnology and green synthesis by plant extracts. In fact, it involves using various plants for the synthesis of NPs due to the green and facile routes that are used on a large scale in industrial companies. [7] Plant extracts could be used as reducing and capping agents for metal ions Ni. They can also be applied as eco-friendly adsorbents for the removal of dyes and pollutants from waste effluents from tanneries and textile industries and the determination of the chemical oxygen demand of water [8]. The two manifestations are nickel metal and metal oxides. These two possess catalytic activity, antimicrobial activity, magnetic properties, biocompatibility, and sorption nature. The two manifestations are nickel metal and metal oxides. These two possess catalytic activity, antimicrobial activity, magnetic properties, biocompatibility, and sorption nature. According to reports, food packaging surfaces might be coated with biocompatible zinc oxide nanoparticles made from zinc acetate utilizing a green, eco-friendly technique that involves extracting the leaf of the Cassia auriculata plant. This would help prevent biocontamination. The reports say that the synthesis of biocompatible zinc oxide nanoparticles from zinc acetate through an eco-friendly green process using the leaf extract of Cassia auriculata leaf may be used in the surface coating of food packages to prevent bacterial contamination [9-10]. Various techniques have been adopted for the synthesis of NiO nanostructures, such as sol-gel, co-precipitation, hydrothermal, solvo-thermal,