A Review on Health Benefits of Malva sylvestris L. Nutritional Compounds for Metabolites, Antioxidants, and Anti-Inflammatory, Anticancer, and Antimicrobial Applications

Mousavi, Seyyed Mojtaba; Hashemi, Seyyed Alireza; Behbudi, Gity; Mazraedoost, Sargol; Omidifar, Navid; Gholami, Ahmad; Chiang, Wei‐Hung; Babapoor, Aziz; Rumjit, Nelson Pynadathu

doi:10.1155/2021/5548404

Cited by 39 publications

(23 citation statements)

References 79 publications

(48 reference statements)

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“…Therefore, phytochemical properties of different plants and their derived bioactive analogues occur in assorted portions of plants; like as flower, seed, stem, bark, fruit, leaf, and embryo (Figure 1) [11,13]. Moreover, all these medicinal plants are eminent to yield numerous bioactive metabolites with various pharmacological attributes together with antidiabetic, antiosteoporotic, antimicrobial, hepatoprotective, anti-inflammatory, antimalarial, antiageing, immunomodulator, antioxidant, antihypertension, anticancer, and others (Table 1) [14][15][16][17]. Many have been shown to have anticancer properties; inhibiting cancer cell-related activating proteins, signaling pathways, and enzymes such as topoisomerase enzyme, cyclooxigenase, MMP, MAPK/ERK, TNK, Akt, cytokines, Bcl-2, PI3K, CDK4 kinases, CDK2, CDC2, mechanistic target of rapamycin (mTOR), or by activating DNA repair mechanism [11,18,19].…”

Section: Introductionmentioning

confidence: 99%

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Siddiqui

Jahan

Singh

et al. 2022

BioMed Research International

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Cancer is one of the primary causes of mortality globally, and the discovery of new anticancer drugs is the most important need in recent times. Natural products have been recognized as effective in fight against various diseases including cancer for over 50 years. Plants and microbes are the primary and potential sources of natural compounds to fight against cancer. Moreover, researches in the field of plant-based natural compounds have moved towards advanced and molecular level understandings from the last few decades, leading to the development of potent anticancer agents. Also, plants have been accepted as abundant and prosperous sources for the development of novel therapeutic agents for the management and prevention of different cancer types. The high toxicity of some cancer chemotherapy drugs, as well as their unfavorable side effects and drugs resistance, drives up the demand for natural compounds as new anticancer drugs. In this detailed evidence-based mechanistic review, facts and information about various medicinal plants, their bioactive compounds with their potent anticancer activities against different cancers have been gathered, with further approach to represent the molecular mechanism behind the anticancer activity of these plants. This review will be beneficial for investigators/scientists globally involved in the development of natural, safe, effective, and economical therapeutic agents/drugs against various cancers. This might be an important contribution in the field of drug discovery, where drugs can be used alone or in combination to increase the efficacy of newly synthesized drugs.

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Section: Introductionmentioning

confidence: 99%

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Siddiqui

Jahan

Singh

et al. 2022

BioMed Research International

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“…Among the 43 families, Malvaceae was the most species-heavy (n=11) with maximum numbers of medicinal plants. Malvacecae is considered to be one among the most over-utilized plant family in the world and its pharmacological significances are also known for many years (38)(39)(40). Apocynaceae and Fabaceae were the 2 other families rich with 10 species each, representing various life forms including undershrub, twiner, climber-many of which had medicinal properties.…”

Section: Resultsmentioning

confidence: 99%

Remnant vegetation in farmland - its significance in ethnobotany and local ecosystem

Dastidar¹,

Basu²,

Venkatraman³

et al. 2022

Plant Sci. Today

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This paper evaluated the structure of remnant vegetation (RV) in and around the farmlands of Kancheepuram District, Tamil Nadu of Southern India, to understand its significance in the local ecosystem. Stratified quadrats along nine randomly selected transects were used for sampling vegetation. The study recorded 2495 specimens of 96 plant species under 43 families in 1848 quadrats (88 of 10 m × 10 m, 352 of 5 m × 5 m and 1408 of 1 m × 1 m dimensions) while there was a possibility of recording more species with better sampling efforts. To know the ethnobotanical uses of plants, interviews were conducted with local villagers and people belonging to the Irula tribe, and later the data were collated with published information. Sixty -six plant species were recorded with traditional uses in food, fodder, fuel, condiment and medicine. Prosopis juliflora, an alien invasive species, was a serious threat to the native flora since higher P. juliflora abundance was associated with declining diversity of other plants. The study found that the absence of monitoring and management protocols leading to uncontrolled propagation of invasive species could cause potential damage to the region’s dry evergreen forests, which were often located near the farmlands.

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“…Plant has also been used for its anti-inflammatory and antimicrobial potential for the mitigation of cut, burns and wound healings [139][140][141]. Sylvestris flower extract contains flavones, flavonols, malvidin, malvin, malvaline, delphinidin, genistein; myricetin, anthocyanin, which are responsible for their pharmacological and biological activities [142,143]. Afshar et al established the wound healing potential of plants using in vivo mouse wound models.…”

Section: Malva Sylvestrismentioning

confidence: 99%

Mechanistic Insights and Therapeutic Potential of Natural Products in Amelioration of Wound Healing

Sharma¹,

Kumar²,

Shri³

et al. 2023

Preprint

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Wound healing is a process through which skin maintains itself. Once a wound occurs, the inflammatory and proliferative stages are instigated in reaction to injury. It is established that wound restorative comprises four stages including haemostasis, inflammation, proliferation, and remodeling. The amelioration of wound healing is very challenging as tumors can develop at the site of chronic injury. There are numerous plants, plant extracts and plant based natural products were widely used by tribal communities from ancient times for the treatment of cuts, burns, scars, burns and wounds. The therapeutic potential of these plants is recognized due to the presence of phytomolecules such as phenolic compounds, flavonoids, triterpenoids, saponins, tannins, alkaloids and glycosides. The plant used for the treatments of wound healing includes Achillea millefolium, Andrographis paniculata, Boswellia sacra, Calendula officinalis, Crocus sativus, Curcuma longa, Ehretia laevis, Ehretia microphylla, Glycyrrhiza glabra, Malva sylvestris, Rosmarinus officinalis and Salvia officinalis. This assemblage comprises the structures of phytomolecules isolated from the different extracts of these plants, mechanistic insights and important key findings responsible for wound healing. The mechanistic insights involved in wound healing are similar to cytotoxic, anti-inflammatory and antioxidant agents such as ROS generation, DNA fragmentation and western blotting. This review article is an effort to bridge the gaps in the prevailing literature and thus offers gigantic scope for researchers and academicians betrothed in validation of the customary claims and development of safer and efficient and worldwide recognized natural potential candidates as drugs for healing of wounds, burns and cuts.

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A Review on Health Benefits of Malva sylvestris L. Nutritional Compounds for Metabolites, Antioxidants, and Anti-Inflammatory, Anticancer, and Antimicrobial Applications

Cited by 39 publications

References 79 publications

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Plants in Anticancer Drug Discovery: From Molecular Mechanism to Chemoprevention

Remnant vegetation in farmland - its significance in ethnobotany and local ecosystem

Mechanistic Insights and Therapeutic Potential of Natural Products in Amelioration of Wound Healing

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