A review on Light-initiated crosslinking of biomaterials stained with Rose Bengal for “Nanosuturing” Macromolecular interfaces

Alvarez-López, Constanza; Aguirre‐Soto, Alan

doi:10.1016/j.matpr.2020.10.159

Cited by 2 publications

(5 citation statements)

References 60 publications

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“…RB was chosen as a well‐known PS from the xanthene dye family [ 58 ] that has been studied as an efficient promoter of photochemical tissue bonding (PTB). [ 59–61 ] For instance, it has been demonstrated that ROS generated during RB excitation (using green light) can induce collagen crosslinking. [ 59–62 ] Type I collagen is the most abundant protein in the human skin and has been used as a proof‐of‐concept to demonstrate a compound's capability for PTB.…”

Section: Resultsmentioning

confidence: 99%

“…[ 59–61 ] For instance, it has been demonstrated that ROS generated during RB excitation (using green light) can induce collagen crosslinking. [ 59–62 ] Type I collagen is the most abundant protein in the human skin and has been used as a proof‐of‐concept to demonstrate a compound's capability for PTB. [ 61,63,64 ] To date, to the best of our knowledge, only Han et al.…”

Section: Resultsmentioning

confidence: 99%

“…[ 59–62 ] Type I collagen is the most abundant protein in the human skin and has been used as a proof‐of‐concept to demonstrate a compound's capability for PTB. [ 61,63,64 ] To date, to the best of our knowledge, only Han et al. and Zhu et al.…”

Section: Resultsmentioning

confidence: 99%

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Phytoglycogen Encapsulation of Lanthanide‐Based Nanoparticles as an Optical Imaging Platform with Therapeutic Potential

Rodrigues

Calvert

Crawford

et al. 2022

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Lanthanide‐based upconverting nanoparticles (UCNPs) are largely sought‐after for biomedical applications ranging from bioimaging to therapy. A straightforward strategy is proposed here using the naturally sourced polymer phytoglycogen to coencapsulate UCNPs with hydrophobic photosensitizers as an optical imaging platform and light‐induced therapeutic agents. The resulting multifunctional sub‐micrometer‐sized luminescent beads are shown to be cytocompatible as carrier materials, which encourages the assessment of their potential in biomedical applications. The loading of UCNPs of various elemental compositions enables multicolor hyperspectral imaging of the UCNP‐loaded beads, endowing these materials with the potential to serve as luminescent tags for multiplexed imaging or simultaneous detection of different moieties under near‐infrared (NIR) excitation. Coencapsulation of UCNPs and Rose Bengal opens the door for potential application of these microcarriers for collagen crosslinking. Alternatively, coloading UCNPs with Chlorin e6 enables NIR‐light triggered generation of reactive oxygen species. Overall, the developed encapsulation methodology offers a straightforward and noncytotoxic strategy yielding water‐dispersible UCNPs while preserving their bright and color‐tunable upconversion emission that would allow them to fulfill their potential as multifunctional platforms for biomedical applications.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Phytoglycogen Encapsulation of Lanthanide‐Based Nanoparticles as an Optical Imaging Platform with Therapeutic Potential

Rodrigues

Calvert

Crawford

et al. 2022

Small

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“…PH-10 ® is a topical RB hydrogel formulation that selectively delivers RB to epithelial tissue and is currently involved in clinical trials [ 20 ]. PH-10 ® has been employed for managing psoriasis and atopic dermatitis with encouraging results.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the action mechanism of RB in this disease has yet to be elucidated. Furthermore, RB alone or in combination with stimuli-responsive therapies has been reported to be a promising candidate for a plethora of therapeutic applications ranging from photochemical tissue bonding [ 20 , 21 , 22 ], white hair removal [ 23 ], plantar warts [ 24 ] and eradication of certain skin infections [ 7 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Fluorescence-Coupled Techniques for Determining Rose Bengal in Dermatological Formulations and Their Application to Ex Vivo Skin Deposition Studies

et al. 2023

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Rose Bengal (RB) is a fluorescent dye with several potential biomedical applications, particularly in dermatology. Due to RB’s poor physicochemical properties, several advanced delivery systems have been developed as a potential tool to promote its permeation across the skin. Nevertheless, no validated quantitative method to analyse RB within the skin is described in the literature. Considering RB exhibits a conjugated ring system, the current investigation proposes fluorescence-based techniques beneficial for qualitatively and quantitatively determining RB delivered to the skin. Notably, the development and validation of a fluorescence-coupled HPLC method to quantify RB within the skin matrix are herein described for the first time. The method was validated based on the ICH, FDA and EMA guidelines, and the validated parameters included specificity, linearity, LOD, LLOQ, accuracy and precision, and carry-over and dilution integrity. Finally, the method was applied to evaluate RB’s ex vivo permeation and deposition profiles when loaded into dermatological formulations. Concerning qualitative determination, multiphoton microscopy was used to track the RB distribution within the skin strata, and fluorescence emission spectra were investigated to evaluate RB’s behaviour when interacting with different environments. The analytical method proved specific, precise, accurate and sensitive to analyse RB in the skin. In addition, qualitative side-analytical techniques were revealed to play an essential role in evaluating the performance of RB’s dermatological formulation.

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A review on Light-initiated crosslinking of biomaterials stained with Rose Bengal for “Nanosuturing” Macromolecular interfaces

Cited by 2 publications

References 60 publications

Phytoglycogen Encapsulation of Lanthanide‐Based Nanoparticles as an Optical Imaging Platform with Therapeutic Potential

Phytoglycogen Encapsulation of Lanthanide‐Based Nanoparticles as an Optical Imaging Platform with Therapeutic Potential

Fluorescence-Coupled Techniques for Determining Rose Bengal in Dermatological Formulations and Their Application to Ex Vivo Skin Deposition Studies

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