A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation

Mehdi, Seema; Wani, Shahid Ud Din; Krishna, K.L.; Kinattingal, Nabeel; Roohi, Tamsheel Fatima

doi:10.1016/j.bbrep.2023.101571

Cited by 15 publications

(5 citation statements)

References 142 publications

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“…This provides a solid ethio-pathogenic argument for the use of anti-inflammatory agents for controlling depressive symptoms in MDD. Moreover, a meta-analysis stipulated that the symptoms of depression could be controlled with Celecoxib, a non-steroidal antiinflammatory drug (NSAID) presenting high COX-2 selectivity, without developing any serious side effects [45].…”

Section: Discussionmentioning

confidence: 99%

Analysis of MicroRNA-Transcription Factors Co-Regulatory Network Linking Depression and Vitamin D Deficiency

Sala-Cirtog,

Sirbu

2024

IJMS

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Depression and vitamin D deficiency are often co-occurring pathologies, the common pathogenetic ground of which includes an augmented inflammatory response. However, the molecular details of this relationship remain unclear. Here, we used a bioinformatic approach to analyze GEO transcriptome datasets of major depressive disorder (MDD) and vitamin D deficiency (VDD) to identify the hub genes within the regulatory networks of commonly differentially expressed genes (DEGs). The MDD-VDD shared regulatory network contains 100 DEGs (71 upregulated and 29 downregulated), with six hub genes (PECAM1, TLR2, PTGS2, LRRK2, HCK, and IL18) all significantly upregulated, of which PTGS2 (also known as COX2) shows the highest inference score and reference count. The subsequent analysis of the miRNA-transcription factors network identified COX2, miR-146a-5p, and miR-181c-5p as key co-regulatory actors in the MDD-VDD shared molecular pathogenic mechanisms. Subsequent analysis of published MDD and VDD transcriptome data confirmed the importance of the identified hub genes, further validating our bioinformatic analytical pipeline. Our study demonstrated that PTGS2 was highly upregulated in both depressive patients and patients with low vitamin D plasma levels. Therefore, regulators targeting PTGS2, like miR-146a-5p and miR181c-5p, may have great potential in controlling both diseases simultaneously, accentuating their role in future research.

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Section: Discussionmentioning

confidence: 99%

Analysis of MicroRNA-Transcription Factors Co-Regulatory Network Linking Depression and Vitamin D Deficiency

Sala-Cirtog,

Sirbu

2024

IJMS

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“…Oysters, crabs, lobsters, beef, poultry, hard cheese, as well as seeds, nuts, and whole grains are good dietary sources of Zn [ 35 , 38 , 39 , 40 ]. There is no true Zn storage system in the human body; i.e., humans cannot store Zn for long.…”

Section: Zincmentioning

confidence: 99%

“…Zn deficiency can present with various clinical features: growth retardation, delayed bone maturation and sexual development; hypogonadism and defective spermatogenesis in males; immune dysregulation and increased susceptibility to various infections; vision impairment (e.g., night blindness or photophobia); neural system dysfunction (including depression and anxiety); diarrhea or poor appetite; reduced taste and smell acuity; and skin lesions (erythema, erosions, etc. ), hair loss, nail dystrophy and slow wound healing [ 35 , 36 , 37 , 38 , 41 , 42 ]. In developing countries, Zn deficiency is considered one of the main causes of morbidity [ 41 ].…”

Section: Zincmentioning

confidence: 99%

Zinc, Magnesium and Vitamin K Supplementation in Vitamin D Deficiency: Pathophysiological Background and Implications for Clinical Practice

Bleizgys

2024

Nutrients

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Zinc, magnesium, and vitamin K are important nutrients for humans. There are various factors that contribute to the development of their deficiency, which might result in or exacerbate various diseases. These nutrients can also interact with vitamin D metabolism and activity. This review discusses the main aspects of zinc, magnesium and vitamin K metabolism and action in the body, their clinical significance, and the “crosstalk” with vitamin D, as well as providing general suggestions for clinical practice when supplementation with these nutrients might be useful, in addition to vitamin D supplementation.

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“…Stress has been shown to exacerbate various physical and mental health issues, 9 and can lead to detrimental changes in neural functioning, 10 neural connectivity, 11 and brain size, 12 and lead to damage to the stress response system. 13 Notably, other systems, such as the cardiovascular, 14 metabolic, 15 or immune systems, 16 are also affected by stress because the stress response system is interactive with these other systems and can cause damage to these systems if stress is unregulated or chronic. Further, the breakdown of these systems can lead to increased inflammation that mediates other diseases and lead to a wide range of stress-exacerbated diseases across the lifespan, such as diabetes, dementia, and hypertension.…”

Section: Introductionmentioning

confidence: 99%

The Evolution of Mindfulness-Based Stress Reduction Teacher Training Programs for People Who Serve Historically Underrepresented Racial and Ethnic Groups

Dejene,

Carter,

Woo

et al. 2024

Global Advances in Integrative Medicine and Health

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Background There is a lack of mindfulness instructors from underserved/underrepresented communities who have completed systematic mindfulness teacher-training programs to meet the growing demand for culturally responsive mindfulness training in those communities. Objectives To investigate strategies for increasing the representation of Mindfulness-Based Stress Reduction (MBSR) teachers who serve historically underrepresented racial and ethnic groups. Methods Conducted through 4 one-hour Zoom focus groups (n = 54; women = 74%), this study queried individuals with experience serving underrepresented racial and ethnic communities, and had mindfulness experience, on how to increase participation from underrepresented communities in mindfulness. Thematic analysis of transcripts of participant responses involved double-coding by three team members, supporting rigorous evaluation of the data. All respondents who expressed interest in participating enrolled (no dropout from study enrollment to participation in focus groups). Results The study identified four key themes that illuminate challenges and essential adaptations for MBSR teacher training aimed at individuals serving historically underrepresented racial and ethnic groups. These themes include: (1) Cost and time commitment; (2) Trauma sensitivity; (3) Cultural Awareness; and (4) Diversity in teachers. Conclusion Participants provided actionable recommendations poised to facilitate the expansion of MBSR into more diverse communities, emphasizing optimal benefits and effective communication of inherent healing strengths within these communities. The findings underscore the compelling interest among leaders in marginalized communities to extend the reach of MBSR through culturally responsive approaches. This involves guiding pertinent adjustments and encouraging greater involvement of underserved communities in MBSR teacher training programs.

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A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation

Cited by 15 publications

References 142 publications

Analysis of MicroRNA-Transcription Factors Co-Regulatory Network Linking Depression and Vitamin D Deficiency

Analysis of MicroRNA-Transcription Factors Co-Regulatory Network Linking Depression and Vitamin D Deficiency

Zinc, Magnesium and Vitamin K Supplementation in Vitamin D Deficiency: Pathophysiological Background and Implications for Clinical Practice

The Evolution of Mindfulness-Based Stress Reduction Teacher Training Programs for People Who Serve Historically Underrepresented Racial and Ethnic Groups

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