Palm oil mill secondary effluent (POMSE) is a byproduct of the biological treatment of palm oil mill effluent. This research aims to investigate the mechanism of membrane fouling in the treatment of POMSE using a hybrid membrane photocatalytic reactor (MPR). The effectiveness of MPR in POMSE treatment is currently limited due to membrane fouling on the membrane surface. This study focuses on understanding the various mechanisms of membrane fouling, including complete blocking, intermediate blocking, standard blocking, and cake filtration. The determination of each fouling mechanism is achieved through an analysis of normalized flux data employing the Wiesner and Aptel equation. The results demonstrate a high degree of model fitness (R2 = 0.9576) for MPR Run 3, confirming its effectiveness. Based on the (R2) values and the fitted parameter (Ks^(-1)), it is evident that, under varying pH levels, catalyst types, catalyst loading, and initial POMSE concentrations, the cake formation fouling mechanism prevails in MPR Run. In conclusion, this research holds promising potential for implementation in the wastewater treatment industry while ensuring compliance with environmental regulations.