A review on nanostructure-based mercury (II) detection and monitoring focusing on aptamer and oligonucleotide biosensors

Şahin, Samet; Çağlayan, Mustafa Oğuzhan; Üstündağ, Zafer

doi:10.1016/j.talanta.2020.121437

Cited by 56 publications

(23 citation statements)

References 268 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the help of the NMR results, we first assigned all the peaks in 1 H and 13 C NMR spectra using COSY and HMQC spectra. After successful assignments of all peaks, we then examine the HMBC spectrum to observe the heteronuclear correlation of the H (7) with C(10) and C (11). This correlation can distinguish two possible products from each other.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

A New Indole Substituted Biphenyldiamine Derivative Schiff Base: A New Sensor Application for the Selective Detection of Hg(II) Ions

Kaya

2021

Russ J Coord Chem

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

“…1), there must be a correlation of H (7) with C (10) and no any correlation with C(11). In the case of formation of structure V, there must be a correlation of H (7) with C(10) and C (11) in the HMBC spectrum (Fig. 1).…”

Section: Methodsmentioning

confidence: 99%

A New Indole Substituted Biphenyldiamine Derivative Schiff Base: A New Sensor Application for the Selective Detection of Hg(II) Ions

Kaya

2021

Russ J Coord Chem

View full text Add to dashboard Cite

show abstract

“…Fluorescence-based aptasensors are characterized by high sensitivity, large-detection ranges, multiplexing capabilities, rapid assaying, and the highly selective recognition of aptamers for several targets, which can be distinguished under UV light, in comparison with the colorimetric sensor's signals that are distinguished using visible light. The integration of both fluorescent materials (fluorophore dyes and fluorescent nanoparticles such as upconversion nanoparticles (UCNPs), GO, and CQDs) and aptamers can produce high sensitivity and selectivity, and a rapid analysis strategy, making them useful candidates for fluorescence-aptasensor bioassays [113][114][115]. The recognition affinity between aptamers and analytes induces conformational changes in the aptamer.…”

Section: Fluorescence Aptasensormentioning

confidence: 99%

“…Recently, enzymes such as HRP, glucose oxidase, and alkaline phosphatase, and electroactive compounds such as QDs, ferrocene (Fc), ferrocyanide, methylene blue (MB), and Cd nanoparticles were successfully incorporated in electrochemical aptasensor technologies to be used as signal enhancers [114,194]. A different strategy was integrated in an electrochemical aptasensor for assaying different targets-AFB1-activated protein C, OTC, patulin (PAT), thrombin, and Pb 2+ , among others-by monitoring the electrochemical signals of the released labeling substrates as a result of competitive targets [13,43,[195][196][197][198][199][200].…”

Section: Electrochemical Aptasensormentioning

confidence: 99%

Recent Advances in Aptamer Sensors

Shaban

Kim

2021

Sensors

View full text Add to dashboard Cite

Recently, aptamers have attracted attention in the biosensing field as signal recognition elements because of their high binding affinity toward specific targets such as proteins, cells, small molecules, and even metal ions, antibodies for which are difficult to obtain. Aptamers are single oligonucleotides generated by in vitro selection mechanisms via the systematic evolution of ligand exponential enrichment (SELEX) process. In addition to their high binding affinity, aptamers can be easily functionalized and engineered, providing several signaling modes such as colorimetric, fluorometric, and electrochemical, in what are known as aptasensors. In this review, recent advances in aptasensors as powerful biosensor probes that could be used in different fields, including environmental monitoring, clinical diagnosis, and drug monitoring, are described. Advances in aptamer-based colorimetric, fluorometric, and electrochemical aptasensing with their advantages and disadvantages are summarized and critically discussed. Additionally, future prospects are pointed out to facilitate the development of aptasensor technology for different targets.

show abstract

“…Subsequently, because many enzymes are commercial and the quality between batches can be easily controlled, the enzyme-driven signal amplification has become a convenient approach for mercury sensing. Until now, several reviews have been published on DNA biosensors for the detection of Hg 2+ [33][34][35]. However, few reviews on the strategy of enzyme-driven signal amplification have been reported.…”

Section: Introductionmentioning

confidence: 99%

Construction of DNA Biosensors for Mercury (II) Ion Detection Based on Enzyme-Driven Signal Amplification Strategy

Wang

2021

Biomolecules

View full text Add to dashboard Cite

Mercury ion (Hg2+) is a well-known toxic heavy metal ion. It is harmful for human health even at low concentrations in the environment. Therefore, it is very important to measure the level of Hg2+. Many methods, reviewed in several papers, have been established on DNA biosensors for detecting Hg2+. However, few reviews on the strategy of enzyme-driven signal amplification have been reported. In this paper, we reviewed this topic by dividing the enzymes into nucleases and DNAzymes according to their chemical nature. Initially, we introduce the nucleases including Exo III, Exo I, Nickase, DSN, and DNase I. In this section, the Exo III-driven signal amplification strategy was described in detail. Because Hg2+ can help ssDNA fold into dsDNA by T-Hg-T, and the substrate of Exo III is dsDNA, Exo III can be used to design Hg2+ biosensor very flexibly. Then, the DNAzyme-assisted signal amplification strategies were reviewed in three categories, including UO22+-specific DNAzymes, Cu2+-specific DNAzymes and Mg2+-specific DNAzymes. In this section, the Mg2+-specific DNAzyme was introduced in detail, because this DNAzyme has highly catalytic activity, and Mg2+ is very common ion which is not harmful to the environment. Finally, the challenges and future perspectives were discussed.

show abstract

A review on nanostructure-based mercury (II) detection and monitoring focusing on aptamer and oligonucleotide biosensors

Cited by 56 publications

References 268 publications

A New Indole Substituted Biphenyldiamine Derivative Schiff Base: A New Sensor Application for the Selective Detection of Hg(II) Ions

A New Indole Substituted Biphenyldiamine Derivative Schiff Base: A New Sensor Application for the Selective Detection of Hg(II) Ions

Recent Advances in Aptamer Sensors

Construction of DNA Biosensors for Mercury (II) Ion Detection Based on Enzyme-Driven Signal Amplification Strategy

Contact Info

Product

Resources

About