A review on parenteral delivery of peptides and proteins

Exploring the utility of hybrid siloxane-phosphocholine (SiPC) liposomes as drug delivery vehicles

“…The lipid was exposed to buffer (pH 4.5, 7.5, or 10.5) for a period of 24 h. Aer this time the buffer was removed via freeze drying to yield the isolated lipid species. 1 H and 31 P NMR analysis of the isolated lipid material (without any purication) produced virtually identical spectra to the pure, virgin, lipid compounds (Fig. 6-9); residual water can be observed in the 1 H NMR spectra of both lipids.…”

“…One of the ongoing avenues of research within the pharmaceutical industry is the design and development of effective drug delivery systems. 1 Many different modalities for the delivery of bioactive compounds have been developed including those based on polysaccharides, 2 proteins, 3,4 nanoparticles, 5,6 and emulsions [7][8][9] to name but a few. In principle, drug delivery systems offer the capacity to enhance the efficacy of therapeutic agents by increasing the physiological concentration of these agents, as well as allowing therapeutic agents to be targeted to specic subcellular locations.…”

Application of QCM in Peptide and Protein-Based Drug Product Development

“…Almost all of the currently commercially available biologics and peptide drugs are offered either as liquids or lyophilizates for parenteral use [ 104 ]. Degradation of those drug molecules is likely to occur during their production, processing, storage, and administration.…”

Therapeutic applications of transdermal microneedles

“…using a hypodermic needle. However, the use of injections is often associated with the patient's discomfort, pain, generation of sharp waste, and potential of abuse (4). Oral route has its disadvantages with a primary hurdle of significant first-pass metabolism and poor absorption in the gastrointestinal tract (5).…”