A Review on Pharmacological and Analytical Aspects of Naringenin

Abstract

Flavonoids are a widely distributed group of phytochemicals having benzo-pyrone nucleus, and more than 4,000 different flavonoids have been described and categorized into flavonols, flavones, flavanones, isoflavones, catechins and anthocyanidins. Flavonoids occurs naturally in fruits, vegetables, nuts, and beverages such as coffee, tea, and red wine, as well as in medical herbs. Flavonoids are responsible for the different colors of plant parts and are important constituents of the human diet. Flavanoids have different pharmacological activities, such as antioxidant, anti-allergic, antibacterial, anti-inflammatory, antimutagenic and anticancer activity. Naringenin belongs to the flavanones and is mainly found in fruits (grapefruit and oranges) and vegetables. Pharmacologically, it has anticancer, antimutagenic, anti-inflammatory, antioxidant, antiproliferative and antiatherogenic activities. Naringenin is used for the treatments of osteoporosis, cancer and cardiovascular diseases, and showed lipid-lowering and insulin-like properties. In the present review, detailed pharmacological and analytical aspects of naringenin have been presented, which revealed the impressive pharmacological profile and the possible usefulness in the treatment of different types of diseases in the future. The information provided in this communication will act as an important source for development of effective medicines for the treatment of various disorders.

Naringenin attenuates highly active antiretroviral therapy‐induced spermDNAfragmentations and testicular toxicity in Sprague‐Dawley rats

“…Alternatively, the use of adjuvant therapy that may ameliorate the toxic effects of these drugs without impairing the efficacy will be highly beneficial. Phytochemicals such as flavonoids, derived from fruits, have been found to be particularly useful in reproductive sciences (Patel et al ., ; Abarikwu et al ., ). The beneficial properties include counteracting certain oxidative processes in the body (Ali et al ., ), which may be induced by medications (Sak, ; Kumar & Tiku, ).…”

Dietary Antioxidants in Experimental Models of Liver Diseases

“…Naringenin is also recognized as 5,7,4′-thihydroxyflavanone, and it is a flavanone found in citrus fruits and tomatoes [81]. In a recent study, Yang et al [82] have reported that naringenin did not cause any harmful effects in beagle dogs, the maximum time of exposure being 180 days and with doses varying of 20, 100, or 500 mg/kg body weight per day.…”

Inhibition of polyamine biosynthesis for toxicity control in Serratia marcescens strain WW4 by targeting ornithine decarboxylase: a structure-based virtual screening study

“…This response may be as an agonist, antagonist depending on the physiological response produced. The analysis of the inhibition profile against predicted ODC model of Serratia marscens strain WW4 reveals that natural compounds Conessine, Sumaresinolic acid (Patil et al, 2015), DNC, Exolone, Naringenin Patel et al, 2014), Hesperidin (Peterson et al, 2006) and Baicailin (Liu et al, 2016b) were the top most inhibiting candidates with Docking Affinity -9.7 (Kcal/mol), -9.2 (Kcal/mol), -9.0 (Kcal/mol), -8.9 (Kcal/mol), -8.8 (Kcal/mol), -8.8 (Kcal/mol) and -8.2 (Kcal/mol) behave as inhibitors of polyamine biosynthesis in Serratia marscens strain WW4. The residues in active site compactly bind with the ligands (Figure 6).…”