A Review on Pharmacological and Therapeutic Potential of Aloe barbadensis Miller

Sharma, Deepak; Purohit, Naimish; Chaubey, Shiwa; Tiwari, Mukesh; Bhadauriya, Mradu; Mohit, .; Bhasker, Nilam; Kumar, Dharmendra

doi:10.9734/ejmp/2022/v33i630471

Cited by 3 publications

(1 citation statement)

References 106 publications

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“…Aloe vera gel is known to exert anti-inflammatory, antibacterial, antioxidant, immune-stimulating and hypoglycemic characteristics, along with a range of other pharmacological effects [20,21]. Fani and Kohanteb [22] (2012), reported that aloe vera gel can exhibit a significant bactericidal effect against cariogenic bacteria.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effects of dentifrices against Streptococcus mutans in children: a comparative in vitro study

2024

JOCPD

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Fluoridated dentifrices have antibacterial effects on children's teeth. On the other hand, the side effects encountered with the use of them have led researchers to look for safe alternatives. This study aimed to determine the antibacterial effect of different commercially available fluoride-free dentifrices on Streptococcus mutans (S. mutans) in comparison with different concentrations of fluoridated dentifrices. Study groups comprised of fluoride-free dentifrices, which contain Probiotic (Activated Charcoal Probiotic Dentifrice-Group P), Aloe Vera-Group AV and Salivary Proteins-Group SP. Fluoridated dentifrices containing 1450 ppm fluoride-Control Group 1 and 500 ppm fluoride-Control Group 2 served as control groups. Antibacterial activity was assessed by Minimum Inhibitory Concentrations and agar well diffusion assays on S. mutans. Biofilm inhibition assay was performed with dentifrices, which had antibacterial activities, and a negative control phosphate-buffered saline (Group PBS) on sterile hydroxyapatite discs against S. mutans. Statistical evaluation was performed. Only group AV showed an antibacterial effect on S. mutans, while control groups showed a similar antibacterial effect. The mean number of viable bacteria present in S. mutans biofilm in Control Group 1 and 2 and Group AV were statistically significantly lower than that in Group PBS, but there were no statistically significant differences between Control Groups and Group AV. Antibacterial activity of commercial dentifrices against S. mutans may be exerted by antibacterial components other than fluoride. Aloe veracontaining toothpaste showed an antibacterial effect on S. mutans, although not as much as the fluoride-containing toothpastes in the control groups. However, further in vivo and long-term studies are required.

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Section: Introductionmentioning

confidence: 99%

Antibacterial effects of dentifrices against Streptococcus mutans in children: a comparative in vitro study

2024

JOCPD

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A critical review on phytochemicals as antiviral medications for SARS-CoV-2 virus infection

Das,

Panigrahy

2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Exploring the therapeutic potential of Aloin: unraveling neuroprotective and anticancer mechanisms, and strategies for enhanced stability and delivery

Zimbone,

Romanucci,

Zarrelli

et al. 2024

Sci Rep

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We investigate the therapeutic potential of Aloin A and Aloin B, two natural compounds derived from Aloe vera leaves, focusing on their neuroprotective and anticancer properties. The structural differences between these two epimers suggest that they may exhibit distinct pharmacological properties. Our investigations revealed that both epimers are not stable in aqueous solution and tend to degrade rapidly, with their concentration decreasing by over 50% within approximately 12 h. These results underscore the importance of addressing issues such as the need for encapsulation into effective drug delivery systems to enhance stability. ThT fluorescence experiments showed that neither compound was able to inhibit Aβ amyloid aggregation, indicating that other mechanisms may be responsible for their neuroprotective effects. Next, an equimolar mixture of Aloin A and Aloin B demonstrated an ability to inhibit proteasome in tube tests, which is suggestive of potential anticancer properties, in accordance with antiproliferative effects observed in neuroblastoma SH-SY5Y and HeLa cell lines. Higher water stability and increased antiproliferative activity were observed by encapsulation in carbon dot nanoparticles, suggesting a promising potential for further in vivo studies.

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A Review on Pharmacological and Therapeutic Potential of Aloe barbadensis Miller

Cited by 3 publications

References 106 publications

Antibacterial effects of dentifrices against Streptococcus mutans in children: a comparative in vitro study

Antibacterial effects of dentifrices against Streptococcus mutans in children: a comparative in vitro study

A critical review on phytochemicals as antiviral medications for SARS-CoV-2 virus infection

Exploring the therapeutic potential of Aloin: unraveling neuroprotective and anticancer mechanisms, and strategies for enhanced stability and delivery

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