A Review on Pharmacological Properties of Coumarins

Abstract

The coumarin (benzopyran-2-one, or chromen-2-one) ring system, present in many natural products, displays diverse pharmacological properties. It has attracted the attention of chemists and medicinal chemists for decades. Many molecules based on the coumarin ring system have been described utilizing innovative synthetic methods. These synthetic routes have led to interesting analogues of coumarins which possess pharmacological activities like anti-HIV, antimicrobial, antiinflammatory, anticancer, anti-TB, anticonvulsant and MAO inhibitory properties. Details of these studies, correlating structure with biological activity are described in this review.

Novel metal complexes of 3‐acetylcoumarin‐2‐hydrazinobenzothiazole Schiff base: Design, structural characterizations, DNA binding, DFT calculations, molecular docking and biological studies

“…Electronic spectral data for Hachbt and its complexes (1)(2)(3)(4)(5) in DMSO are listed in the Experimental section and are shown in Figure S3. The ligand exhibits three bands at 289, 365 and 546 nm due to intraligand π-π* and n-π* transitions.…”

“…Coumarins (1,2‐benzopyrane) are naturally occurring compounds that are found in many plants as well as in many fungal and bacterial species 1 . For decades, this class of the compound has attracted significant attention from chemists and biologists owing to the biological and pharmacological properties, including antibacterial, antifungal, 2 insecticidal, 3 anti‐inflammatory, anticoagulant, anti‐HIV and antitumor activities 1 .…”

“…Coumarins (1,2‐benzopyrane) are naturally occurring compounds that are found in many plants as well as in many fungal and bacterial species 1 . For decades, this class of the compound has attracted significant attention from chemists and biologists owing to the biological and pharmacological properties, including antibacterial, antifungal, 2 insecticidal, 3 anti‐inflammatory, anticoagulant, anti‐HIV and antitumor activities 1 . It has been reported that the bioactivity of coumarin‐based compounds is increased by introducing metal ions to form complexes 4 because these metal ions often possess different oxidation states that play a crucial role in bioinorganic chemistry and in redox enzymatic systems 5 .…”

“…1 For decades, this class of the compound has attracted significant attention from chemists and biologists owing to the biological and pharmacological properties, including antibacterial, antifungal, 2 insecticidal, 3 anti-inflammatory, anticoagulant, anti-HIV and antitumor activities. 1 It has been reported that the bioactivity of coumarin-based compounds is increased by introducing metal ions to form complexes 4 because these metal ions often possess different oxidation states that play a crucial role in bioinorganic chemistry and in redox enzymatic systems. 5 Furthermore, benzothiazole and its derivatives are an important class of heterocyclic nitrogen-sulfur containing compounds that exist in nature.…”

“…Five new Cu (II), Zn (II), Pd (II), Ru (III) and Ag(I) complexes, derived from the 3-acetylcoumarin-2-hydrazinobenzothiazole Schiff base (Hachbt), have been synthesized and characterized. The structures were established with the aid of elemental analyses (C, H, N), FT-IR, 1 H-NMR, ESR, UV-visible and ESI-mass spectra. The complexes were also investigated by magnetic susceptibility, thermal gravimetric analysis (TG-DTA) and cyclic voltammetry measurements.…”