A review on phytochemistry of Paederia foetida Linn

Dutta, Partha; Marbaniang, Khamtibha; Sen, Saikat; Dey, Biplab Kumar; Talukdar, Narayan Chandra

doi:10.1016/j.phyplu.2023.100411

Cited by 11 publications

(5 citation statements)

References 70 publications

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“…These enzymes are primarily involved in the process of detoxification, where they oxidize molecules that are not polar into more execrable and polar ones [117] . NPs that are substrates or inhibitors of the CYP450 enzymes include coumarins [118] . As an example, A53 , a linear furanocoumarin present in grapefruits and abundant in citrus fruits, is a powerful inhibitor of multiple CYP450 enzymes [119] .…”

Section: Results From the Reviewing And Their Related Discussionmentioning

confidence: 99%

“…[117] NPs that are substrates or inhibitors of the CYP450 enzymes include coumarins. [118] As an example, A53, a linear furanocoumarin present in grapefruits and abundant in citrus fruits, is a powerful inhibitor of multiple CYP450 enzymes. [119] Because many of these CYP450 enzymes are necessary for the metabolism and bioactivation processes of drugs in living cells, these interactions are particularly significant in the pharmacological sciences.…”

Section: Cytochrome P450-inhibition Capacity Of Pdcsmentioning

confidence: 99%

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Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Younes,

Mustafa

2024

Chemistry & Biodiversity

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Plant‐derived coumarin (PDC) is a naturally occurring heterocyclic backbone that belongs to the benzopyrone family. PDC and its based products are characterized by low toxicity and high distribution in a variety of herbal treatments that have numerous therapeutic potentials. These include anticoagulants, antibacterials, anti‐inflammatory agents, anticancer agents, antioxidants, and others. So, it may be appropriate to investigate the qualities and potential bioactivities of PDCs. This article provides an overview of the biomedical potentials, availability, and clinical use possibilities of PDCs, with a focus on their important modes of action, using information on various pharmacological qualities discovered. The data used in this study came from published research between 2015 and 2023. We reviewed a selection of databases, including PubMed, Scopus, Web of Science, and Google Scholar, during that period. In conclusion, because of their abundance in medicinal plants, the clinical biochemistry attributes of PDCs are currently of interest. In a variety of medical specialties, PDCs serve a useful role as therapeutic agents.

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Section: Results From the Reviewing And Their Related Discussionmentioning

confidence: 99%

Section: Cytochrome P450-inhibition Capacity Of Pdcsmentioning

confidence: 99%

Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Younes,

Mustafa

2024

Chemistry & Biodiversity

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“…This plant belonging to the Rubiaceae family has been known for its anti‐inflammatory properties since pre‐historic times and was even used for the treatment of rheumatic diseases, being endowed with principal bio‐actives like iridoid glycosides, flavonoid glycosides, phenolic derivatives, anthraquinones, triterpenoids, phytosterols, essential oils, sterols and galacturonic acids (Dutta et al, 2023). Essential medicinal extracts are obtained from multiple parts of this invaluable plant, such as diuretic functions from a decoction of the leaves, emetics from roots, dental analgesics from fruits and leukoderma suppressors from the seeds, to name a few.…”

Section: Herbal Interventions With Potential Anti‐rheumatic Activitymentioning

confidence: 99%

“…This plant belonging to the Rubiaceae family has been known for its anti-inflammatory properties since pre-historic times and was even used for the treatment of rheumatic diseases, being endowed with principal bio-actives like iridoid glycosides, flavonoid glycosides, phenolic derivatives, anthraquinones, triterpenoids, phytosterols, essential oils, sterols and galacturonic acids (Dutta et al, 2023).…”

Section: Paederia Foetida Lmentioning

confidence: 99%

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

Chatterjee,

Jayaprakasan,

Chakrabarty

et al. 2024

Phytotherapy Research

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Rheumatoid arthritis is a chronic autoimmune inflammatory disease characterized by immune response overexpression, causing pain and swelling in the synovial joints. This condition is caused by auto‐reactive antibodies that attack self‐antigens due to their incapacity to distinguish between self and foreign molecules. Dysregulated activity within numerous signalling and immunological pathways supports the disease's development and progression, elevating its complexity. While current treatments provide some alleviation, their effectiveness is accompanied by a variety of adverse effects that are inherent in conventional medications. As a result, there is a deep‐rooted necessity to investigate alternate therapeutic strategies capable of neutralizing these disadvantages. Medicinal herbs display a variety of potent bioactive phytochemicals that are effective in the complementary management of disease, thus generating an enormous potency for the researchers to delve deep into the development of novel phytomedicine against autoimmune diseases, although additional evidence and understanding are required in terms of their efficacy and pharmacodynamic mechanisms. This literature‐based review highlights the dysregulation of immune tolerance in rheumatoid arthritis, analyses the pathophysiology, elucidates relevant signalling pathways involved, evaluates present and future therapy options and underscores the therapeutic attributes of a diverse array of medicinal herbs in addressing this severe disease.

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“…Trichomes are present on both surfaces elongating to produce uniseriate trichomes and mesophyll is composed of single-layered palisade cells and 3-4 layer spongy tissue. The midribs are composed of single-layered epidermis covered with cuticles, ground tissue consists of 2-5 layered collenchyma towards the upper and lower side of parenchyma 3 . Aerial parts contain methyl mercaptan, cysteine, keto alcohol, paederolone, a keto compound, paederepne and betasitosterol, protein, carbohydrates, glycosides, essential oils, quinines, alkaloids, iridoid glycosides, sitosterol, stigmasterol, amino acids and volatile oil 4 .…”

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confidence: 99%

Untitled

2023

IJPSR

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Paederia foetida is one of the lesser-studied plants that has been utilized as food and medicine by several ethnic groups against stomach pain, bowel disease, snake bite, bone fractures burns, or scalding. Scientific research revealed that the plant exhibits extensive pharmacological activity, including antidiarrheal, antibacterial, anti-inflammatory, anti-diabetic, antiemetic, antioxidant and antirheumatoid. Based on the online poll results, information was acquired about P. foetida's transition from traditional use to scientific validation. Moreover, qualitative and quantitative phytochemical analysis of the plant indicates the presence of 36 important chemical constituents such as; methyl-mercaptan, phenolic, high percentage of minerals, urosolic acid, β-sitosterol, oleanolic acid, arachidic acid. The different phytoconstituents of the plant justify the ethno-medicinal and pharmacological application of the plant. In conclusion, the results of this analysis will produce a new, safe, and low-cost therapeutic strategy for identify and isolate novel chemical entities in drug discovery. Additionally, it may aid in separating fresh lead compounds for future clinical study research. This plant could be an excellent source of safe and effective medicinal and nutritional herbal remedies for human and animal consumption. INTRODUCTION:Over the past decades, Herbal and Ayurvedic drugs have been considered a subject of World importance with medicinal and economic implications 1 . Researchers are mainly focusing on the traditionally used medicinal plants by various ethnic groups to develop medication against different ailments. Paederia foetida is one of the most highly used medicinal plants mainly in the northeastern region of India and is well known for its gastro-protective and anti-diarrheal activity. It is widely available in India, Bangladesh, Japan,

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A review on phytochemistry of Paederia foetida Linn

Cited by 11 publications

References 70 publications

Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Comprehensive insights into rheumatoid arthritis: Pathophysiology, current therapies and herbal alternatives for effective disease management

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