A review on phytoestrogens: Current status and future direction

Patra, Surendra; Pal, Soumitra; Ghosh, Kuntal; Pradhan, Shrabani; Chakrabarti, Sudipta

doi:10.22271/phyto.2022.v11.i5d.14509

Cited by 4 publications

(9 citation statements)

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“…Classified into three main categories-isoflavones, lignans, and coumestansphytoestrogens are widely distributed in numerous plant-based foods [10]. These include soybeans, flaxseeds, legumes, and an array of fruits and vegetables.…”

Section: Phytoestrogens: a Brief Overviewmentioning

confidence: 99%

From Plant to Patient: The Metabolic Benefits of Phytoestrogens

Kumar Verma,

Kumar Singh,

Tripathi

2024

Herbs and Spices - New Perspectives in Human Health and Food Industry

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In recent years, there has been a growing interest in the potential health benefits of phytoestrogens, a diverse group of naturally occurring compounds found in plants. These compounds, with structural similarities to estrogen, are found in foods such as soybeans, flaxseeds and sesame seeds, and are studied for their roles in modulating hormonal activity and antioxidant properties. Their estrogen-like functions make them particularly interesting in managing conditions exacerbated by hormonal imbalances, such as type 2 diabetes, obesity, cardiovascular diseases, and osteoporosis. Phytoestrogens enhance insulin sensitivity and glucose metabolism, while their anti-oxidant properties neutralize free radicals and inhibit lipid peroxidation. They also influence fat metabolism and reduce adipogenesis, addressing oxidative stress and inflammation. Their estrogenic effects improve bone mineral density and reduce fracture risks, particularly in postmenopausal women, highlighting their broad potential in metabolic disease management. This growing body of research suggests that phytoestrogens, due to their unique properties and diverse mechanisms of action, could be a valuable addition to dietary and therapeutic strategies in the prevention and management of various metabolic diseases. This chapter delves into the multifaceted roles of phytoestrogens in metabolic disorders, with a special focus on their antioxidant properties.

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Section: Phytoestrogens: a Brief Overviewmentioning

confidence: 99%

From Plant to Patient: The Metabolic Benefits of Phytoestrogens

Kumar Verma,

Kumar Singh,

Tripathi

2024

Herbs and Spices - New Perspectives in Human Health and Food Industry

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“…Some of the common sources of phytoestrogen include soy (isoflavones), red clover (isoflavones), flaxseed (lignans), hops, etc. Structurally, they are similar to the 17‐β‐estradiol, which has the capability to bind both alpha (ERα) and beta (ERβ) estrogen receptors, and mimic the action of estrogens on target organs (Patra et al, 2022). They exhibit similar, rather weaker, effects than mammalian estrogens and are widely consumed by menopausal women for minimizing symptoms of menopause and postmenopausal bone loss.…”

Section: Management Of Menopause and Related Disordersmentioning

confidence: 99%

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Mohapatra,

Kumar,

Aggarwal

et al. 2024

Phytotherapy Research

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Women face a significant change in their reproductive health as menopause sets in. It is marred with numerous physiological changes that negatively impact their quality of life. This universal, transition phase is associated with menopausal and postmenopausal syndrome, which may spread over 2–10 years. This creates a depletion of female hormones causing physical, mental, sexual and social problems and may, later on, manifest as postmenopausal osteoporosis leading to weak bones, causing fractures and ultimately morbidity and mortality. Menopausal hormone therapy generally encompasses the correction of hormone balance through various pharmacological agents, but the associated side effects often lead to cessation of therapy with poor clinical outcomes. However, it has been noticed that phytotherapeutics is trusted by women for the amelioration of symptoms related to menopause and for improving bone health. This could primarily be due to their reduced side effects and lesser costs. This review attempts to bring forth the suitability of phytotherapeutics/herbals for the management of menopausal, postmenopausal syndrome, and menopausal osteoporosis through several published research. It tries to enlist the available botanicals with their key constituents and mechanism of action for mitigating symptoms associated with menopause as well as osteoporosis. It also includes a list of a few herbal commercial products available for these complications. The article also intends to collate the findings of various clinical trials and patents available in this field and provide a window for newer research avenues in this highly important yet ignored health segment.

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“…These signaling pathways are vital for the maintenance of homeostasis and cell survival, as is apoptosis. Phytoestrogen was used to inhibit angiogenesis and metastasis processes by utilizing its antioxidant potential, thus controlling the major damage that occurs during cancer (Patra et al, 2023). However, some of the related studies contradict this finding and involve breast cancer patients treated with phytoestrogens (Andrew & Izzo, 2017; Patisaul & Jefferson, 2010; Setchell & Clerici, 2010; Sirotkin & Harrath, 2014).…”

Section: Phytoestrogens and Their Therapeutic Effectsmentioning

confidence: 99%

Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance

Chavda,

Chaudhari,

Balar

et al. 2024

Phytotherapy Research

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Phytoestrogens, also known as xenoestrogens, are secondary metabolites derived from plants that have similar structures and biological effects as human estrogens. These compounds do not directly affect biological functions but can act as agonists or antagonists depending on the level of endogenous estrogen in the body. Phytoestrogens may have an epigenetic mechanism of action independent of estrogen receptors. These compounds are found in more than 300 plant species and are synthesized through the phenylpropanoid pathway, with specific enzymes leading to various chemical structures. Phytoestrogens, primarily phenolic compounds, include isoflavonoids, flavonoids, stilbenes, and lignans. Extensive research in animals and humans has demonstrated the protective effects of phytoestrogens on estrogen‐dependent diseases. Clinical trials have also shown their potential benefits in conditions such as osteoporosis, Parkinson's disease, and certain types of cancer. This review provides a concise overview of phytoestrogen classification, chemical diversity, and biosynthesis and discusses the potential therapeutic effects of phytoestrogens, as well as their preclinical and clinical development.

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A review on phytoestrogens: Current status and future direction

Cited by 4 publications

References 0 publications

From Plant to Patient: The Metabolic Benefits of Phytoestrogens

From Plant to Patient: The Metabolic Benefits of Phytoestrogens

Phytotherapeutic approach for conquering menopausal syndrome and osteoporosis

Phytoestrogens: Chemistry, potential health benefits, and their medicinal importance

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