A review on potential therapeutic targets for the treatment of leishmaniasis

Sheikh, Sabahat Yasmeen; Hassan, Firoj; Shukla, Deepanjali; Bala, Shashi; Faruqui, Tabrez; Akhter, Yusuf; Khan, Abdul Rahman; Nasibullah, Malik

doi:10.1016/j.parint.2024.102863

Cited by 10 publications

(1 citation statement)

References 160 publications

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“…In recent years, much research has focused on the search for new therapies to control leishmaniasis. These include, for example, marbofloxacin, a third-generation fluoroquinolone, and DDD853651/GSK3186899, a pyrazolopyrimidine ( Sheikh et al, 2024 ). Natural compounds such as chalcones, alkaloids, quinolines and pyridines have also been shown to be effective against these parasites ( Pal et al, 2023 ), with ursolic acid, coumarin, gallic acid and apigenin, among others, being particularly active ( Afonso et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Bethencourt-Estrella,

Delgado-Hernández,

López-Arencibia

et al. 2024

International Journal for Parasitology: Drugs and Drug Resistan

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Section: Introductionmentioning

confidence: 99%

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Bethencourt-Estrella,

Delgado-Hernández,

López-Arencibia

et al. 2024

International Journal for Parasitology: Drugs and Drug Resistan

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In vitro and ex vivo evaluation of hydroalcoholic tobacco leaf extract as an anti-leishmanial agent against Leishmania major: A comparative study with Glucantime

Berenji,

Sangani,

Salari

et al. 2025

South African Journal of Botany

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Understanding American tegumentary leishmaniasis in urban Montes Claros, Brazil: insights from clinical, immunological and therapeutic investigations

Lopes,

Lima,

Ribeiro

et al. 2024

Parasitology

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The challenge of American tegumentary leishmaniasis (ATL) continues in Brazil, presenting a persistent public health issue despite initiatives aimed at public outreach, vector control and health education. To gain a deeper understanding of this disease, a study was conducted in an endemic region located in the northern region of the state of Minas Gerais, Brazil. The study monitored 30 resident patients diagnosed with ATL, using serum samples from 6 healthy individuals as controls. The localized cutaneous form of the disease was found to be predominant, with lesions appearing on various parts of the body and the majority of the affected individuals being male. The study found significantly higher levels of IgG anti-α-Gal antibodies in ATL-infected patients compared to healthy individuals. Treatment of 19 patients with meglumine antimoniate resulted in limited improvement in symptoms for most. Nonetheless, the study found that 12 patients who completed treatment with epithelialization of the lesions showed a significant decrease in IgG anti-α-Gal antibodies, indicating potential applications of this antibody in the diagnosis and monitoring of the disease. The study also identified Leishmania species in 7 analysed patients, revealing 6 cases infected by Leishmania braziliensis and 1 by L. infantum, with a significant difference in the anti-α-Gal responses. The findings of the study emphasize the urgent need for the development of human vaccines and innovative treatment strategies adapted to the diversity of Leishmania species causing cutaneous leishmaniasis and individual patient responses to improve the clinical management of ATL in Brazil and similar endemic regions.

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A review on potential therapeutic targets for the treatment of leishmaniasis

Cited by 10 publications

References 160 publications

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

Acrylonitrile derivatives: In vitro activity and mechanism of cell death induction against Trypanosoma cruzi and Leishmania amazonensis

In vitro and ex vivo evaluation of hydroalcoholic tobacco leaf extract as an anti-leishmanial agent against Leishmania major: A comparative study with Glucantime

Understanding American tegumentary leishmaniasis in urban Montes Claros, Brazil: insights from clinical, immunological and therapeutic investigations

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